CHRONIC ENDOMETRITIS AS ONE OF THE FACTORS OF UNSUCCESSFUL ATTEMPS OF EMBRYO IMPLANTATION IN ASSISTED REPRODUCTIVE TECHNOLOGIES PROGRAMS
DOI:
https://doi.org/10.11603/24116-4944.2019.2.10930Keywords:
chronic endometritis, hysteroscopy, infertility, endometrial biopsy, assisted reproductive technologies, reproductive lossesAbstract
Infertile marriage remains still an actual medical and social problem in modern obstetrics, gynecology and reproductive medicine. Today, more and more couples are using assisted reproductive technology as one of the most effective treatments for various forms of infertility. One of the leading places in the structure of diseases affecting women’s fertility is the inflammation of the pelvic organs. Chronic endometritis is a chronic inflammatory process of the endometrium that adversely affects the reproductive function of women (reduces endometrial receptivity, conduces of reproductive failures). The article presents the main aspects of etiology, pathogenesis, diagnosis and treatment of chronic endometritis, the tactics of conducting women with this pathology in programs of assisted reproductive technologies.
References
Kitaya, K., Matsubayashi, H., Yamaguchi, K., Nishiyama, R., Takaya, Y., Ishikawa, T., …, & Yamada, H. (2016). Chronic endometritis: potential cause of infertility and obstetric and neonatal complications. Am. J. Reprod. Immunol., 75 (1), 13-22. DOI: https://doi.org/10.1111/aji.12438
Kitaya, K., Yamaguchi, T., Yasuo, T., Okubo, T., & Honjo, H. (2007). Post-ovulatory rise of endometrial CD16(-) natural killer cells: in situ proliferation of residual cells or selective recruitment from circulating peripheral blood? J. Reprod. Immunol., 76 (1-2), 45–53. DOI: https://doi.org/10.1016/j.jri.2007.03.010
Lyzikova, Yu.A. (2015). Khronicheskiy endometrit kak prichina narusheniy reproduktivnoy funktsii u zhenshchin [Chronic endometritis as a cause of reproductive dysfunction in women]. Problemy zdorovia i ekologii – Problems of Health and Ecology, 9-16 [in Russian].
Benyuk, V.O., Goncharenko, V.M., Zabudskiy, O.V., & Yarmak, V.S. (2015). Rol khronichnoho endometrytu v henezi hiperplastychnykh protsesiv endometriia [The role of chronic endometritis in the genesis of hyperplastic endometrial processes]. Zdorovye zhenshchiny – Woman's Health, 6 (102), 16-21 [in Ukrainian].
Moreno, I., Cicinelli, E., Garcia-Grau, I., Gonzalez-Monfort, M., Bau, D., Vilella, F., …, & Simon, C. (2018). The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. AJOG, 218 (6), 602. DOI: https://doi.org/10.1016/j.ajog.2018.02.012
Gombolevskaya, N.A., & Marchenko, L.A. (2012). Sovremennyye kriterii diagnostiki khronicheskogo endometrita (obzor literatury). [Modern criteria for the diagnosis of chronic endometritis (literature review)]. Problemy reproduktsii – Reproduction Problems, 18 (1), 42-46 [in Russian].
Chen, Y.Q., Fang, R.L., Luo, Y.N., & Luo, C.Q. (2016). Analysis of the diagnostic value of CD138 for chronic endometritis, the risk factors for the pathogenesis of chronic endometritis and the effect of chronic endometritis on pregnancy: a cohort study. BMC Womens Health, 16 (1), 60. doi: 10.1186/s12905-016-0341-3. DOI: https://doi.org/10.1186/s12905-016-0341-3
Cicinelli, E., De Ziegler, D., Nicoletti, R., Colafiglio, G., Saliani, N., Resta, L., …, & De Vito, D. (2008). Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertil Steril, 89, 677-684. DOI: https://doi.org/10.1016/j.fertnstert.2007.03.074
Cicinelli, E., Matteo, M., Tinelli, R., Lepera, A., Alfonso, R., Indraccolo, U., …, & Resta, L. (2015). Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy. Hum. Reprod. Oxf. Engl., 30, 323-330. DOI: https://doi.org/10.1093/humrep/deu292
Haggerty, C., Hillier, S., Bass, D., & Ness, R. (2004). Evaluation and Clinical Health study investigators. Bacterial vaginosis and anaerobic bacteria are associated with endometritis. Clin. Infect. Dis., 39, 990-995. DOI: https://doi.org/10.1086/423963
Puente, E., Alonso, L., Laganà, A.S., Ghezzi, F., Casarin, J., & Carugno, J. (2020). Chronic endometritis: Old problem, novel insights and future challenges. Int. J. Fertil. Steril., 13 (4), 250-256.
Resta, L., Palumbo, M., Piscitelli, D., Grazia Fiore, M., & Cicinelli, E. (2012). Histology of micro polyps in chronic endometritis. Histopathology, 60 (4), 670-674. DOI: https://doi.org/10.1111/j.1365-2559.2011.04099.x
Yasuo, T., & Kitaya, K. (2010). Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod. Pathol., 23 (8), 1136-1146.
Kitaya, K., Tada, Y., Hayashi, T., Taguchi, S., Funabiki, M., & Nakamura, Y. (2014). Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis. Am. J. Reprod. Immunol., 72 (4), 386-391. DOI: https://doi.org/10.1111/aji.12277
Wu, D., Kimura, F., Zheng, L., Ishida, M., Niwa, Y., Hirata K, ..., & Murakami, T. (2017). Chronic endometritis modifies decidualization in human endometrial stromal cells. Reprod. Biol. Endocrinol., 15 (1), 16. DOI: https://doi.org/10.1186/s12958-017-0233-x
Kitaya, K., Yasuo, T., Tada, Y., Hayashi, T., Iwaki, Y., Karita, M., …, & Yamada, H. (2014). Unusual inflammation in gynecologic pathology associated with defective endometrial receptivity. Histol. Histopathol., 29 (9), 1113-1127.
Vaskkivuo, T., Stenbäck, F., & Tapanainen, J. (2002). Apoptosis and apoptosisrelated factors Bcl-2, Bax, tumor necrosis factor-alpha, and NFkappaB in human endometrial hyperplasia and carcinoma. Cancer, 95 (7), 1463-1471.
Vatansever, H., Lacin, S., & Ozbilgin, M. (2005). Changed Bcl:Bax ratio in endometrium of patients with unexplained infertility. Acta Histochem., 107 (5), 345-355. DOI: https://doi.org/10.1016/j.acthis.2005.06.012
Sfakianoudis, K., Simopoulou, M., Nitsos, N., Lazaros, L., Rapani, A., Pantou, A., …, & Pantos, K. (2019). Successful Implantation and Live Birth Following Autologous Platelet-rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis. In Vivo, 33 (2), 515-521. DOI: https://doi.org/10.21873/invivo.11504
Strelko, G.V., & Ulanov, V.V. (2018). Klinichne znachennia khronichnoho endometrytu u zhinok zi znyzhenoiu vidpoviddiu na stymuliaciiu yaiechnykiv u programi ekstrakorporalnogo zaplidnennia [Clinical value of chronic endometritis in women with reduced performance for stimulation of patients with extracorporeal program]. Zdorovye zhenshchiny – Woman's Health, 4 (130), 92-97 [in Ukrainian].
Kozyreva, E., Tyurina, N., Andreeva, N., Marenkova, I., & Kuznetsova M. (2019). Ultrasonic and dopplerometric characteristics of chronic endometritis of women with infertility and miscarriage. Electronic Journal of General Medicine, 16. Article No: em108.
Khmil, S.V., Khmil, M.S., Drozdovska, Yu.B., & Chudiiovych, N.Ya. (2018). Efektyvnist histerorezektoskopii u zhinok z bezpliddiam na foni leiomiomy matky v prohramakh dopomizhnykh reproduktyvnykh texnolohii [Efficiency of hysteroresectoscopy in women with infertility in the background of uterine leiomyomas in the programs of assisted reproductive technologies]. Visnyk sotsialnoi hihiieny ta orhanizatsii okhorony zdorovia Ukrainy – Bulletin of Social Hygiene and Health Protection Organization of Ukraine, 4 (78), 51-55 [in Ukrainian].
Klivlend, G.O., Klyucharov, I.V., Dzamukoov, R.A., & Tsibulkina, V.N. (2016). Aktualnyye voprosy diagnostiki khronicheskogo endometrita [Topical issues in the diagnosis of chronic endometritis]. Innovatsionnyye tekhnology v meditsine – Innovative Technologies in Medicine, 2, 4 (96) [in Russian].
Huchon, C., Koskas, M., Agostini, A., Akladios, C., Alouini, S., Bauville, E., ..., & Fauconnier, A. (2015). Operative hysteroscopy versus vacuum aspiration for incomplete spontaneous abortion (HY-PER): study protocol for a randomized controlled trial. Trials, 16, 363. doi: 10.1186/s13063-015-0900-1. DOI: https://doi.org/10.1186/s13063-015-0900-1
Nosenko, O.M., & Saenko, A.І. (2014). Dіahnostyka khronіchnoho endometrytu u patsіentok z bezplіddiam [Diagnosis of chronic endometritis in patients with no-cause]. Reproduktivnaya endokrinologiya – Reproductive Endocrinology, 2, 101 [in Ukrainian].
Avramenko, N.V., Gridina, I.B., Lomeyko, E.A. (2015). Khronicheskiy endometrit kak faktor narusheniya reproduktivnogo zdorovia zhenshchin [Chronic endometritis as a factor in the reproductive health of women]. Zaporozhskiy meditsinskiy zhurnal – Zaporozhye Medical Journal, 6 (93), 93-97 [in Russian].
Kyshakevych, І.T., Kotsabin, N.V., & Radchenko, V.V. (2017). Endometrіi u fokusі uvahy hіnekoloha: rol hіsteroskopіi ta іmunohіstokhіmіi v dіahnostytsі khronіchnoho endometriyu. vybіr lіkuvannia [Endometrium in the focus of the respect of the gynecologist: the role of the hysteroscopy and the immunohistochemistry in the diagnosis of chronic endometritis, the vibration of the patient]. Reproduktyvna endokrynolohіia – Reproductive endocrinology, 2 (34), 24-27 [in Ukrainian].
Horban, N.Y., Vovk, I.B., Lysiana, T.O., Ponomariova, I.H., & Zhulkevych, I.V. (2019). Peculiarities of uterine cavity biocenosis in patients with different types of endometrial hyperproliferative pathology. Journal of Medicine and Life, 12 (3), 266-270.
Donska, Yu.V., Loskutova, T.O., Sіmonova, N.V., & Petulko, A.P. (2018). Optymіzatsіia lіkuvannia zhіnok z khronіchnym endometrytom yak rezerv pіdvyshchennia fertylnostі [Optimization of life with chronic endometritis as a reserve of fertility]. WORLD SCIENCE, 10 (38), 28-32 [in Ukrainian].
Dubnitskaya, L.V., & Nazarenko, T.A. (2007). Khronicheskiy endometrit: vozmozhnosti diagnostiki i lecheniya [Chronic endometritis: possibilities for diagnosis and treatment]. Consilium Medicum, 06, 25-28 [in Russian].
Chayka, G.V., Yaremchuk, L.V., Karetna, A.O. (2017). Optymіzatsіia lіkuvannia ta reabіlіtatsіi reproduktyvnoi funktsіi zhіnok z hіperplazіieiu endometrіia na tlі zapalnykh zakhvoriuvan orhanіv maloho tazu [Optimization of treatment and rehabilitation of reproductive function of women with endometrial hyperplasia on the background of pelvic inflammatory diseases] Vіsnik Vіnnitskoho natsіonalnoho medychnoho unіversytetu – Bulletin of the Vinnitsa National Medical University, 2 (21), 306 [in Ukrainian].
Pyrohova, V.І., Kozlovskyi, І.V., & Holota, L.І. (2014). Lіkuvannia khronіchnoho endometrytu u zhіnok z bezplіddiam [Treatment of chronic endometritis in women with infertility]. Aktualnі pitannia pedіatrії, akusherstva ta hіnekolohіi – Actual Problems of Pediatry, Obstetrics and Gynecology, 2, 118 [in Ukrainian].
Mangin, M., Sinha, R., & Fincher, K. (2014). Inflammation and vitamin D: the infection connection. Res., 63 (10), 803-809. DOI: https://doi.org/10.1007/s00011-014-0755-z
Pyrohova, V.І., & Shurpiak, S.O. (2015). Terapіia khronіchnoho endometrytu u zhіnok z porushenniamy reproduktyvnoho zdorovia z pozytsіi podolannia oksydatyvnoho stresu [Therapy of chronic endometritis in women with reproductive health disorders from the standpoint of overcoming oxidative stress]. Zdorovye zhenshchiny – Woman's Health, 6 (102), 60-64 [in Ukrainian].
Voronkova, N.M. (2018). Lіkuvannia khronіchnoho endometrytu na etapі prehravіdarnoi pіdhotovky [Treatment of chronic endometritis at the stage of pregravid preparation]. Klіnіchna endokrinolohіia ta endokrynna khіrurhіia – Clinical Endocrinology and Endocrine History, 4 (68), 81 [in Ukrainian].
Bielecki, T.M., Gazdzik, T.S., Arendt, J., Szczepanski, T., Król, W., & Wielkoszynski, T. (2007). Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study. J. Bone Joint Surg. Br., 89, 417-420. DOI: https://doi.org/10.1302/0301-620X.89B3.18491
Woodall, J., Tucci, M., Mishra, A., & Benghuzzi, H. (2007). Cellular effects of platelet rich plasma: a study on HL-60 macrophage-like cells. Biomed. Sci. Instrum., 43, 266-271.
Marx, R. (2004). Platelet-rich plasma: evidence to support its use. J. Oral. Maxillofac. Surg., 62, 489-496. DOI: https://doi.org/10.1016/j.joms.2003.12.003
Borrione, P., Gianfrancesco, A.D., Pereira, M.T., & Pigozzi, F. (2010). Platelet-rich plasma in muscle healing. Am J. Phys. Med. Rehabil., 89, 854-861. DOI: https://doi.org/10.1097/PHM.0b013e3181f1c1c7
Akeda, K., An, H.S., Okuma, M., Attawia, M., Miyamoto, K., Thonar, E.J.-M.A., …, & Masuda, K. Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. (2006). Osteoarthritis Cartilage, 14, 1272-1280. DOI: https://doi.org/10.1016/j.joca.2006.05.008
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
