THE COURSE OF PREGNANCY, CHILDBIRTH AND PERINATAL OUTCOMES IN WOMEN WITH THREATENED INTERRUPTION OF PREGNANCY AND THE STATUS OF INTERNALLY DISPLACED PERSONS, LIVING IN THE LUHANSK REGION
DOI:
https://doi.org/10.11603/24116-4944.2019.2.10926Keywords:
internally displaced persons, pregnancy, threatened interruption of pregnancy, childbirth, condition of newbornsAbstract
The aim of the study was to evaluate the course of pregnancy, childbirth and perinatal outcomes in women with threatened interruption of pregnancy (TIP) and the status of internally displaced persons (IDPs), living in the Lugansk region, to improve treatment and preventive measures and prevent obstetric and perinatal complications in such women.
Material and methods. A prospective clinical and statistical analysis of the course of pregnancy and childbirth of 42 pregnant women in first and second trimesters of pregnancy which had IDPs status and who were hospitalized regarding TIP in the hospitals located in the Luhansk region was performed (group I). The control group consisted of 64 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational period of pregnancy and place of residence (group II).
Results and Discussion. It has been established that in pregnant women of group I the proportion of diseases of the cardiovascular system, urinary tract, ENT organs, and genital inflammatory diseases was significantly higher; a complicated course of pregnancy and childbirth was registered. The number of cases of acute respiratory viral infection, isthmic-cervical insufficiency, nonspecific vaginitis significantly exceeded the indicators of group II, asymptomatic bacteriuria, recurring threatened interruption of pregnancy, gestational pyelonephritis and ureaplasma infection were found only in pregnant women of group I, the number of cases of anemia there was no significant difference. 7 (16.67 %) women of group I and 3 (4.69 %) – group II (p = 0.048) had preterm birth at 33-37 weeks of gestation, operative delivery was registered in 13 (30.95 %) and 8 (12.50 %) cases, respectively (p = 0.02). Рremature rupture of the membranes was found in 1.91, weakness of labor – in 3.4, premature detachment of the normally located placenta – in 6, fetal distress – in 1.5 more often in women of group I, central placenta previa was noted only in group I.
Conclusions. The presence of a history of chronic female genital inflammatory diseases, sexually transmitted infections, acute respiratory viral infection during pregnancy, threatened interruption of pregnancy in the first and second trimesters, allows pregnant women to be at high risk of developing gestational complications in order to conduct timely treatment. The complicated course of the first and second trimesters of pregnancy had a direct effect on frequency increase of premature termination of pregnancy and operative delivery in women of group I compared with women of group II.
References
Morin, N., Akhtar, A., Barth, J., & Schnyder, U. (2018). Psychiatric disorders in refugees and internally displaced persons after forced displacement: A systematic review. Front Psychiatry, 2, 9, 433. doi: 10.3389/fpsyt.2018.00433. DOI: https://doi.org/10.3389/fpsyt.2018.00433
IDCP Global Overview 2015: People Internally Displaced by Conflict and Violence. (2015). Retrieved from: http://www.internal-displacement.org/sites/default/files/inline-files/20150506-global-overview-2015-en.pdf.
(2015). IDCP Global Overview 2015: People Internally Displaced by Conflict and Violence. Retrieved from: http://www.internal-displacement.org/sites/default/files/inline-files/20150506-global-overview-2015-en.pdf.
Forced displacement in 2018. Global trends. Retrieved from: https://www.unhcr.org/globaltrends2018.
Global Report on Internal Displacement 2019. Retrieved from: http://www.internal-displacement.org/sites/default/files/publications/documents/2019-IDMC-GRID.pdf.
Refugee health. Retrieved from: https://www.unhcr.org/excom/EXCOM/3ae68bf424.html.
Keren, M., Keren, N., Eden, A., Tsangen, S., Weizman, A., & Zalsman, G. (2015). The complex impact of five years of stress related to life-threatening events on pregnancy outcomes: a preliminary retrospective study. Eur. Psychiatry, 30, 2, 317-21. doi: 10.1016/j.eurpsy.2014.10.004. DOI: https://doi.org/10.1016/j.eurpsy.2014.10.004
Ahmed, S.R., El-Sammani, Mel-K., Al-Sheeha, M.A., Aitallah, A.S., Jabin Khan, F., & Ahmed, S.R. (2012). Pregnancy outcome in women with threatened miscarriage: a year study. Mater. Sociomed., 24, 1, 26-8. doi: 10.5455/msm.2012.24.26-28. DOI: https://doi.org/10.5455/msm.2012.24.26-28
Liu, L., Johnson, H.L., Cousens, S., Perin, J., Scott, S., Lawn, J.E., …, & Li, M. (2012). Global, regional, and national causes of child mortality: An updated systematic analysis for 2010 with time trends since 2000. Lancet, 379, 2151-2161. doi: 10.1016/S0140-6736(12)60560-1. DOI: https://doi.org/10.1016/S0140-6736(12)60560-1
Chawanpaiboon, S., Vogel, J.P., Moller, A.-B., Lumbiganon, P., Petzold, M., Hogan D., …, & Laopaiboon, M. (2018). Global, regional, and national estimates of levels of preterm birth in 2014, a systematic review and modelling analysis. Lancet Glob. Health, 7, e37-e46. doi: 10.1016/S2214-109X(18)30451-0. DOI: https://doi.org/10.1016/S2214-109X(18)30451-0
Blencowe, H., Cousens, S., Chou, D., Oestergaard, M., Say, L., Moller, A.B., …, & Lawn, J. (2013). Born too soon: the global epidemiology of 15 million preterm births. Reprod. Health, 10, 1, S2. doi: 10.1186/1742-4755-10-S1-S2. DOI: https://doi.org/10.1186/1742-4755-10-S1-S2
Chang, H.H., Larson, J., Blencowe, H., Spong, C.Y., Howson, C.P., & Cairns-Smith, S., (2013). Preventing preterm births: analysis of trends and potential reductions with interventions in 39 countries with very high human development index. Lancet, 381, 9862, 223-234. doi: 10.1016/S0140-6736(12)61856-X. DOI: https://doi.org/10.1016/S0140-6736(12)61856-X
Leader, J., Bajwa, A., Lanes, A., Hua, X., White, R.R., Rybak, N., & Walker, M. (2018). The effect of very advanced maternal age on maternal and neonatal outcomes: A systematic review. J. Obstet. Gynaecol. Can., 40, 1208-1218. doi: 10.1016/j.jogc.2017.10.027. DOI: https://doi.org/10.1016/j.jogc.2017.10.027
Mayo, J.A., Shachar, B.Z., Stevenson, D.K., & Shaw, G.M. (2017). Nulliparous teenagers and preterm birth in California. J. Périnat. Med., 45, 959–967. doi: 10.1515/jpm-2016-0313. DOI: https://doi.org/10.1515/jpm-2016-0313
Van Zijl, M.D., Koullali, B., Mol, B.W., Pajkrt, E., & Oudijk, M.A. (2016). Prevention of preterm delivery: Current challenges and future prospects. Int. J. Women's Health, 8, 633-645. doi: 10.2147/IJWH.S89317. DOI: https://doi.org/10.2147/IJWH.S89317
Fuchs, F., & Senat, M.V. (2016). Multiple gestations and preterm birth. Semin. Fetal Neonatal Med., 21, 113-120. doi: 10.1016/j.siny.2015.12.010. DOI: https://doi.org/10.1016/j.siny.2015.12.010
Berghella, V. (2012). Universal cervical length screening for prediction and prevention of preterm birth. Obstet. Gynecol. Surv., 67, 653-657. doi: 10.1097/OGX.0b013e318270d5b2. DOI: https://doi.org/10.1097/OGX.0b013e318270d5b2
Lemmers, M., Verschoor, M.A., Hooker, A.B., Opmeer, B.C., Limpens, J., Huirne, J.A., …, & Mol, B.W. (2016). Dilatation and curettage increases the risk of subsequent preterm birth: A systematic review and meta-analysis. Hum. Reprod. (Oxf. Engl.), 31, 34-45. doi: 10.1093/humrep/dev274. DOI: https://doi.org/10.1093/humrep/dev274
Manuck, T.A. (2017). Racial and ethnic differences in preterm birth: A complex, multifactorial problem. Semin. Perinatol., 41, 511-518. doi: 10.1053/j.semperi.2017.08.010. DOI: https://doi.org/10.1053/j.semperi.2017.08.010
Smid, M.C., Lee, J.H., Grant, J.H., Miles, G., Stoddard, G.J., Chapman, D.A., & Manuck, T.A. (2017). Maternal race and intergenerational preterm birth recurrence. Am. J. Obstet. Gynecol., 217, 480.e1-480.e9. doi: 10.1016/j.ajog.2017.05.051. DOI: https://doi.org/10.1016/j.ajog.2017.05.051
Zhang, G., Feenstra, B., Bacelis, J., Liu, X., Muglia, L.M., Juodakis, J., …, & Russell, L. (2017). Genetic associations with gestational duration and spontaneous preterm birth. N. Engl. J. Med., 377, 1156-1167. doi: 10.1056/NEJMoa1612665. DOI: https://doi.org/10.1056/NEJMoa1612665
Frey, H.A., & Klebanoff, M.A. (2016). The epidemiology, etiology, and costs of preterm birth. Semin. Fetal Neonatal Med., 21, 68-73. doi: 10.1016/j.siny.2015.12.011. DOI: https://doi.org/10.1016/j.siny.2015.12.011
Jarde, A., Morais, M., Kingston, D., Giallo, R., MacQueen, G.M., Giglia, L., …, & McDonald, S.D. (2016). Neonatal outcomes in women with untreated antenatal depression compared with women without depression. JAMA Psychiatry, 73, 826-837. doi: 10.1001/jamapsychiatry.2016.0934. DOI: https://doi.org/10.1001/jamapsychiatry.2016.0934
Rubens, C.E., Sadovsky, Y., Muglia, L., Gravett, M.G., Lackritz, E., & Gravett, C. (2014). Prevention of preterm birth: Harnessing science to address the global epidemic. Sci. Transl. Med., 6, 262sr5. doi: 10.1126/scitranslmed.3009871. DOI: https://doi.org/10.1126/scitranslmed.3009871
Kanmaz, A.G., İnan, A.H., Beyan, E., & Budak, A..(2019). The effects of threatened abortions on pregnancy outcomes. Ginekol Pol., 90, 4, 195-200. doi: 10.5603/GP.a2019.0035. DOI: https://doi.org/10.5603/GP.a2019.0035
Weiss, J.L., Malone, F.D., Vidaver, J., Ball, R.H., Nyberg, D.A., Comstock, C.H., …, & D'Alton, M.E. (2004). Threatened abortion: A risk factor for poor pregnancy outcome, a population-based screening study. Am. J. Obstet. Gynecol., 190, 3, 745-750. doi: 10.1016 / j.ajog.2003.09.023. DOI: https://doi.org/10.1016/j.ajog.2003.09.023
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).