DOMESTIC KETOCONAZOLE ADMINISTRATION FOR PREPARTUM PREPARING OF THE PREGNANTS WITH GENITAL CANDIDOSIS
DOI:
https://doi.org/10.11603/24116-4944.2019.2.10921Keywords:
ketoconazole, livagyn-M, pregnancy, vaginal candidosisAbstract
The aim of the study – improvement of pregnancy perinatal consequences and decrease of quantity of obstetrical complications in the pregnants with vaginal discharges based on the ground of domestic ketoconazole (Livagyn-M, Ukraine) administration for prepartum care to the pregnants with genital candidosis and research of its influence on vaginal microbiome.
Materials and Methods The material of research was indicators of vaginal secret bacteriological research results of 32 pregnants with vaginal candidosis and 15 healthy women in 36–38 weeks of pregnancy. The methods of the research were clinical, biochemical, ultrasound examination, microbiological and medico-statistical methods.
Results and Discussion The high fungi Candida concentrations: 1×105 CFU/ml in 28.12 % pregnants, 1×106 CFU/ml – in 53.13 % pregnants, more than 1×107 CFU/ml – in 18.75 % of women were determined with important decrease of Lactobacillus spp. level – more than 1×106 CFU/ml in all patients. Clinical and bacteriological convalescence was in 93.75 % of pregnants after 10-days treatment. Trustworthy increase of Lactobacillus spp. concentration has discovered.
Conclusions. Domestic ketokonazole Livagyn-M has high clinical efficiency in preparturital care to the pregnants with genital candidosis and prophylaxis of intrauteral intranatal fetus infection.
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