PECULIARITIES OF THE STATE OF THE INTESTINAL MICROBIOTA IN WOMEN WITH HABITUAL MISCARRIAGE
DOI:
https://doi.org/10.11603/24116-4944.2019.2.10919Keywords:
recurrent miscarriage, intestinal microbiota, intestinal dysbiosisAbstract
The aim of the study - to determine the state of the intestinal microbiota in women suffering from habitual miscarriage.
Materials and Methods. A total of 53 women aged 21-46 years were divided into 3 groups. Group I (n=15) included women who had the second or third habitual miscarriage in gestation of up to 22 weeks, and group II (n=18) had patients who had one habitual miscarriage in gestation of up to 22 weeks, the control group (n=20) consisted of patients at the gestational age of up to 22 weeks, during which pregnancy progressed without complications. All women were subjected to a comprehensive objective and general clinical examination, in accordance with the requirements of modern clinical protocols and conventional methods. The condition of the intestinal microbiota was assessed by bacteriological examination of faeces immediately after spontaneous abortion. Cultures were performed on the appropriate nutrient media.
Results and Discussion. The overwhelming majority of the women suffering from habitual miscarriage have a marked imbalance of the intestinal microbiota characterized by a significant decrease in the indigenous microflora (Bifidobacterium, Lactobacillus, Escherichia coli, Enterococcus faecium) and enhanced reproduction of optional microorganisms, such as Staphylococcus epidermidis, Proteus, Klebsiella, Clostridium difficile, Candida albicans.
Conclusions. Further in-depth study and analysis of correlations between different taxonomic groups of the intestinal microbiota, which is a kind of indicator of the state of the macroorganism, is an important step in determining the trigger mechanisms of premature pregnancy termination. Therefore, assessment of the quantitative and qualitative composition of the intestinal microbial landscape may be obligatory in pregnancy screening algorithms for women. Therapeutic remodulation of the intestinal microbiota (dietary, medication) can also be one of the important factors in the success of a strategy to prevent and treat habitual miscarriage.
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