TREATMENT OF PREMENSTRUAL SYNDROME WITH THE USE OF ADAPTOL AND SEDATIVE PREPARATIONS OF PLANT ORIGIN
DOI:
https://doi.org/10.11603/24116-4944.2019.1.10202Keywords:
premenstrual syndrome, adaptol, valerianum, peony, persenAbstract
The aim of the study – to achieve high efficiency and good tolerability of the drug in the treatment of patients with premenstrual syndrome with the advantage of vegetative and psychopathological symptoms.
Materials and Methods. We conducted clinical observations in the use of Adaptol for the treatment of PMS in 20 women and sedative herbal remedies (tincture of valerian, peony, persen) – in 12 women. Adaptol is a derivative of two methylated fragments of urea and being a derivative of natural metabolites of the organism has a high degree of biological availability, a large latitude of therapeutic action, does not cause collateral properties. It has the whole spectrum of psychotropic effects characteristic of "traditional" tranquilizers, while at the same time over-the-counter major adverse reactions inherent in the benzodiazepine derivative. The width of the therapeutic effect of Adaptal is due to a vegetative stabilizing, antioxidant, soft, nootropic, antihypoxic, moderate tranquilizing effect. The breadth of the combination of the action of this drug can normalize many functions of the body, as well as restore the mental and physical capacity of patients.
Results and Discussion. We observed for 32 women who hade been diagnosed with PMS. Duration of PMS ranged from one to five years. Nervous-psychiatric disorders in all females were characterized by a large polymorphism of complaints. The clinical picture was dominated by vegetative-vascular disorders: hot flushes, headache, increased fatigability, sleep disorders, depression; neurological symptoms-irritability, tearfulness, emotional lability, anxiety, exasperation. All these clinical manifestations of PMS were noted in the lutein phase of PMS.
Conclusions. 1. Adaptol drug has high efficiency and good tolerance in the treatment of patients with premenstrual syndrome with the superiority of veneto vascular and psychopathological symptoms. Its efficiency is 91.89 %. 2. In patients with long-term premenstrual syndrome and the absence of the effect of using different methods of treatment, it is not necessary to conduct 2–3 courses of therapy with an increase in the dose of Adaptol to 1.2 g per day.
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