THE USE OF CALCIUM IONOPHORE IN IVF – ICSI PROTOCOLS IN PATIENTS WITH A REDUCED REPRODUCTIVE PROGNOSIS
DOI:
https://doi.org/10.11603/24116-4944.2019.1.10201Keywords:
controlled ovarian stimulation, corinollitropin-alpha, Ca ionophore, IVF, ICSIAbstract
The aim of the study – to learn the effectiveness of the use of Ca ionophore in IVF – ICSI protocols in patients with a reduced reproductive prognosis.
Materials and Methods. A study was conducted of the effectiveness of the method of oocyte activation in ECO-ICSI protocols in patients after at least one unsuccessful attempt of ART. Identical CSR protocols were used. Effectiveness was estimated on the basis of embryological (frequency of fertilization, embryo cleavage, percentage of blastulation) and clinical indicators (frequency of pregnancy).
Results and Discussion. The use of calcium ionophore at the time of the ICSI procedure allows to improve the percentage of oocyte fertilization, the percentage of cleavage, the percentage of blastulation. This, in turn, has increased the pregnancy rate in the IVF-ICSI treatment.
Conclusion. Improvement of embryological parameters allowed to significantly improve the results of the frequency of pregnancy in women of older reproductive age with a reduced prognosis for the occurrence of pregnancy.
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