PLANNED SURGICAL TREATMENT OF PRIMARY SYMPTOMATIC CHRONIC VEIN DISEASE IN PREGNANT WOMEN

Authors

  • V. M. Antoniuk-Kysil Municipal Institution "Regional Perinatal Center" of the Rivne Regional Council
  • I. Ya. Dzubanovskyi I. Horbachevsky Ternopil State Medical University
  • V. M. Yenikeeva Municipal Institution "Regional Perinatal Center" of the Rivne Regional Council
  • S. I. Lincher Municipal Institution "Regional Perinatal Center" of the Rivne Regional Council
  • V. M. Lypnyi Municipal Institution "Regional Perinatal Center" of the Rivne Regional Council
  • I. V. Zhulkevych I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/24116-4944.2019.1.10179

Keywords:

primary symptomatic chronic vein disease, surgical treatment of primary symptomatic chronic vein disease during pregnancy, safety of surgical intervention during pregnancy, cardiotocography

Abstract

The aim of the study – to evaluate fetal safety, clinical efficacy for pregnant, planned surgical treatment of primary symptomatic chronic vein disease (PSCVD).

Materials and Methods. 457 pregnant women with PSCVD C2S-C4s,Ep,Asp,p.Pr(basis CEAP, 2002) were operated. All pregnant with surgery underwent duplex vein scanning with mapping of pathological areas (refluxes, varicose conglomerates), evaluation of fetal heart rate and uterine tone in pregnant by cardiotocography (CTG), both before and after surgery, according to the World Health Organization’s criteria of 1985. The comparative evaluation of pregnancy course depending on the treatment method of PSCVD was made.

Results and Discussion. The surgical interventions were performed only with the consent of pregnant women in conditions of obstetric hospital by a vascular surgeon "monotechnologist", in the absence of any contraindications for surgical intervention, from the side of the pregnant woman and the fetus without medication premedication, replacing it by "verbal" with local anesthesia using surgical techniques: CHIVA type with descending development of PSCVD in the basin of saphenous veins, with ascending – combination of CHIVA and ASVAL techniques, in the basin of the non-saphenous veins – cirsodesis of the inguinal canals, extending to external genital organs and/or lower extremities by application of seton sutures in the area of ​​the external inguinal ring. In 100 % of pregnant women during surgery, in the postoperative period there were no violations of the somatic status, uterine tone in pregnant women, fetal heartbeat (CTG data) recorded. According to the subjective evaluation by pregnant there were no disorders of the quantity and quality of fetal movements marked, and they also noted in 98 % of cases the positive clinical outcome of surgical intervention.

Conclusions. Indications for planned operative intervention: absence of positive result from conservative therapy of PSCVD of lower extremities, perineum, external genital organs and inguinal canal; the presence of cosmetic deficiencies in the area of ​​the external genital organs and on the open parts of the lower extremities at the request of pregnant women; prevention of obstetric bleeding with varicose veins of the external genital organs and the perineum by preparing the delivery pathway for safe delivery by a natural way; active prophylaxis of thrombophlebitis, thromboembolic complications during pregnancy and in the postpartum period; surgical interventions performed in a planned manner with PSCVD in the basin of saphenous and/or non-saphenous veins are 100 % safe for pregnant women and fetus, with a positive clinical outcome of 98 % of operated in the postoperative period.

References

Stoyko, Yu.M. (1992). Varikoznaya bolezn [Varicose disease.]. Saint-Petersburg: VMedA [in Russian].

Shekhtman, M.M. (2003). Rukovodstvo po ekstragenitalnoy patologii u beremennykh [Manual on extragenital pathology in pregnant women]. Moscow: Triada-KH [in Russian].

Danilenko-Dixon, D.R., Heit, J.A., & Silverstein, M.D. (2001). Risk factors for deep vein thrombosis and pulmonary embolism during pregnancy or post partum a population based case –control stady. Am. J. Obstet. Gynecol., 184, 2, 104-110. DOI: https://doi.org/10.1067/mob.2001.107919

Budanov, P.V., & Lebedev, V.A. (2008). Osobennosti profilaktiki i lecheniya varikoznoy bolezni ven u beremennykh [Features of the prevention and treatment of varicose veins in pregnant women]. Trudnyy patsiyent – Difficult Patient, 28-31 [in Russian].

Rohova, O.M. (2005). Osoblyvosti stanu imunnoi systemy zdorovykh porodilei zalezhno vid sposobu rozrodzhennia [Features of the state of the immune system of healthy pregnant women depending on the mode of delivery]. PAH - POG, 5, 70-74 [in Ukrainian].

Delaney, A.G. (1983). Anestesia in the pregnаncy woman. Clin. Obsstet. Gynecology, 246-248.

Medved, V.I. (2012). Beremennost-assotsyyrovannya patologiya [Pregnancy-associative pathology]. Zhinochyi likar – Woman’s Doctor, 2, 8-14 [in Ukrainian].

Sansilvestri-Morel, P., Rupin, A., Badier-Commander, C., Fabiani, J.-N., Verbeuren, T. J. (2003). Chronic venous insufficiency: Dysregulation of collagen synthesis. Angiology, 54, 1. Mode access : https://doi.org/10.1177/0003319703054001S03 DOI: https://doi.org/10.1177/0003319703054001S03

Pappas, P., Duran, W., & Hobson, R. (2001). Pathology and cellular physiology of chronic venous insufficiency. Handbook of venous disorders. Guidelines of American Venous Forum. London-New York-New-Deli: Arnold.

Pistorius, M. (2003). Chronic venous insufficiency; The genetic influence. Angiology, 54, 1, s5-12. DOI: https://doi.org/10.1177/0003319703054001S02

Jawien, A. (2003). The influence of environmental factors in chronic venous insufficiency. Angiology, 54, 1, s19-31. DOI: https://doi.org/10.1177/0003319703054001S04

Lenković, M., Cabrijan, L., Gruber, F., Batinac, T., Manestar-Blazić, T., Stanić Zgombić, Z., & Stasić, A. (2009). Effect of progesterone and pregnancy on the development of varicose veins. Acta Dermatovenerol. Croat, 17 (4), 263-267.

Novikov, K.V., Vorobyev, V.V., & Abashin, V.G. (2009). Khirurgicheskoye lecheniye varikoznoy bolezni u beremennykh [Surgical treatment of varicose veins in pregnant women]. Materialy III syezda ambulatornykh khirurgov RF – Proceedings of the III Congress of outpatient surgeons of the Russian Federation. Ambulatorna khirurgiya – Ambulatory Surgery, 3-4 (35-36), 135-136 [in Russian].

Porto, L.C., Mattos da Silveira, P.R., de Carvalho, J.J., & Panico, M. (1995). Connective tissue accumulation in the muscle layer in normal and varicose saphenous veins. Angiology, 46, 3, 243-249. DOI: https://doi.org/10.1177/000331979504600308

Stücker, M., Netz, K., Breuckmann, F., Altmeyer, P., & Mumme, A. (2000). The hystomorphologic changes at the saphenofemoral junction in varicosis of the greater saphenous vein. Vasa, 29, 1, 41-46. DOI: https://doi.org/10.1024/0301-1526.29.1.41

Treivacumar, N.S., Dellagrammaticas, D., Mavor, A.I., & Gough, M.J. (2007). Endovenous laser ablation (EVLA) of great saphenous vein to abolish >paradoxical reflux>in the Giacomini vein ;a shot report. Eur. J. Vasc. Endovasc. Surg. Aug, 34 (2), 229-231. DOI: https://doi.org/10.1016/j.ejvs.2007.01.011

Oguzkurt, L. (2012). Ultrasonographic anatomy of the lower extremity superficial veins. Diagn. Interv. Radiol., 18 (4), 423-430.

Novikov, K.V. (2001). Khirurgicheskoye lecheniye varikoznoy bolezni ven nizhnikh konechnostey u beremennykh [Surgical treatment of varicose veins of the lower extremities in pregnant women]. Ambulatornaya khirurgiya – Ambulatory Surgery, 2 (2), 37-38 [in Russian].

Bauersachs, J., Fleming, I., & Busse, R. (1996). Pathophysiology of chronic venous insufficiency. Phlebolgy, 11, 16-22. DOI: https://doi.org/10.1177/026835559601100105

Zaporozhan, V.M., & Tsehelskyi, M.R. (1996). Akusherstvo i hinekolohiia [Obstetrics and gynecology]. Kyiv: Zdorovia [in Ukrainian].

Kulakov, V.I., Chernukha, Ye.A., & Murashko, A.V. (2000). Zabolevaniya venoznoy sistemy nizhnikh konechnostey u beremennykh, rozhenits i rodilnits [Diseases of the venous system of the lower extremities in pregnant women, parturient women and puerperas]. Vestnik Rossiyskoy assotsiatsii akusherov-ginekologov – Bulletin of the Russian Association of Obstetricians-Gynecologists, 4, 64-70 [in Russian].

Bergan, Dzh.Dzh. (1995). Khronicheskaya venoznaya nedostatochnost [Chronic venous insufficiency]. Angiologiya i sosudistaya khirurgiya – Angiology and Vascular Surgery, 3, 57-59 [in Russian].

Mozes, V.G. (2006). Varikoznoye rasshireniye ven malogo taza u zhenshchin v osnovnyye vozrostno-biologicheskiye periody zhizni [Varicose veins of the pelvis in women in the main age-biological periods of life]. Candidate’s thesis. Tomsk [in Russian].

Murashko, A.V. (2000). Etiologiya i patogenez khronicheskoy venoznoy nedostatochnosti pri beremennosti [Etiology and pathogenesis of chronic venous insufficiency during pregnancy]. Problemy beremennosti – Problems of Pregnancy, 2, 16-21 [in Russian].

Makarov, O.V., Kiriyenko, A.I., & Krasnova, T.A. (1998). Vedeniye beremennosti i rodov pri venoznykh trombembolicheskikh oslozhneniyakh. Vestnik Rossiyskoy assotsiatsii akusherov-ginekologov – Bulletin of the Russian Association of Obstetricians-Gynecologists, 2, 115-122 [in Ukrainian].

Medved, V.I., Benyuk, V.A., & Koval, S.D. (2010). Venoznyye oslozhneniya u beremennykh [Venous complications in pregnant women]. Meditsinskiye aspekty zdorovya zhenshchiny – Medical Aspects of Woman’s Health, 7 (35), 29-33 [in Russian].

Medved, V.I., & Danylkiv, O.O. (2007). Topichna terapiia varykoznoi khvoroby ta khronichnoi venoznoi nedostatnosti u vahitnykh [Topical therapy of varicose veins and chronic venous insufficiency in pregnant women]. Reproduktyvnoye zdorovye zhenshchiny – Reproductive Health of Women, 5, 62-64.

Savelyev, V.S. (1996). Sovremennyye napravleniya v khirurgicheskom lechenii khronicheskoy venoznoy nedostatochnosti [Current trends in the surgical treatment of chronic venous insufficiency]. Flebolimfologiya – Phlebolimphology, s1, 5 [in Russian].

Beniuk, V.O., Medved, V.I., Nikoniuk, T.R., & Koval, S.D. (2010). Profílaktyka uskladnen varykoznoi khvoroby u porodilei [Prevention of complications of varicose veins in pregnant women]. Zdorovye zhenshchiny – Women's Health, 8 (54), 84-87 [in Ukrainian].

Savelyev, V.S. (2013). Rossiyskiye klinicheskiye rekomendatsii po diagnostike i lecheniyu khronicheskikh zabolevaniy ven [Russian clionical recommendations on diagnosis and treatment of chronic diseases of veins]. Flebologiya – Phlebology, 2, 2 [in Russian].

Vanscheidt, W., Heidrich, H., Junger, M., & Rabe, E. (2000). Guidelines for testing drugs for chronic venous insufficiency. VASA, 29, 274-278. DOI: https://doi.org/10.1024/0301-1526.29.4.274

Steins, A., & Junger, M. (2000). Physical therapy in patients with chronic venous insufficiency. Phlebologie, 29, 48-53. DOI: https://doi.org/10.1055/s-0037-1617326

Veverkova, L., Jedika, V., & Wechsler, J. (2006). Analysis of the various procedures used in great saphenous vein surgery in the Czech Republic and benefit of Daflon 500 mg on postoperative symptoms. Phlebolymphology, 13, 195-201.

Krasiński, Z., Sajdak, S., Staniszewski, R., Dzieciu­chowicz, L., Szpurek, D., Krasińska, B., … & Majewski, W. (2006). Pregnancy as a risk factor in development of varicose veins in women. Gynecol Pol., 77 (6), 441-449.

Artymchuk, N.V. (2007). Varikoznoye rasshireniye ven organov malogo taza [Varicose veins of the pelvic organs]. Ros. vest. akush.-ginekologa – Russian West Obstet.-Gynecologists, 6, 74-77 [in Russian].

Shvalb, P.G. (2005). Voprosy angiologii sosudistoy i operativnoy khirurgii [Questions of angiology of vascular and operative surgery]. Ryazan [in Russian].

Reznichenko, G.I., & Antonyuk, I.A. (2004). Profilaktika tromboembolicheskikh oslozhneniy u beremennykh gruppy riska Trombozy v klinicheskiy praktitke: profilaktika, diagnostika, lecheniya]. [Prevention of thromboembolic complications in pregnant women at risk. Thrombosis in clinical practice: prevention, diagnostics, treatment]. Proceedings of the I Ukrainian Conference, 150-152 [in Russian].

Messas, E., Wahl, D., & Pernod, G. (2016). Management of deep-vein thrombosis : A 2015 update. J. Mal. Vasc., 41 (1), 42-50. doi: 10.1016/j.jmv.2015.07.105. DOI: https://doi.org/10.1016/j.jmv.2015.07.105

Rodriguez-Nora, B., & Álvarez-Silvares, E., (2017). Actualización del tratamiento de la insuficiencia venosa en la gestaciónAn update on the treatment of venous insufficiency in pregnancy Medicina de Familia. Semergen, 44, 4, 262-269. Retrieved from: https://doi.org/10.1016/j.semerg.2017.11.003 DOI: https://doi.org/10.1016/j.semerg.2017.11.003

MBB Chir, J.T., Hicks, C.W., & Heller, J.A. (2018). The hemodynamic effects of pregnancy on the lower extremity venous system. Journal of Vascular Surgery: Venous and Lymphatic Disorders, 6, 246-255. Retrieved from: https://doi.org/10.1016/j.jvsv.2017.08.001 DOI: https://doi.org/10.1016/j.jvsv.2017.08.001

Mandyz, S., Ada, F., Ada, Y. (2018). The level of awareness and the attitude of patients recommended for use of compression stockings in Turkish society, and investigation of the factors affecting their use. Patient Prefer Adherence, 12, 399-407. DOI: https://doi.org/10.2147/PPA.S157344

Romanchuk, L.I., & Malanchyn, I.M. (2009). Profilaktyka uskladnen khronichnoi venoznoi nedostatnosti u vahitnykh [Prevention of complications of chronic venous insufficiency in pregnant women]. Zdorovye zhenshchiny – Health of a Woman, 3 (39), 70-73 [in Ukrainian].

Malei, M. (2013). Khronichna venozna nedostatnist v zoni ryzyku [Chronic venous insufficiency in the risk zone]. Meditsinskye aspekty zdorovya zhenshchiny – Medical Aspects of Women’s Health, 4 (68), 46-49 [in Ukrainian].

Vorobyev, V.V., Abashin, V.G., Butilo, I.I., & Petrov, V.V. (2009). Khirurgicheskoye lecheniye varikoznoy bolezni u beremennykh [Surgical treatment of varicose veins in pregnant women]. Ambulatornaya khirurgiya – Outpatient Surgery, 3-4 (35-36).

Novikov, K.V. (2001). Khirurgicheskoye lecheniye varikoznoy bolezni ven nizhnikh konechnostey u beremennykh [Surgical treatment of varicose veins of lower extremities in pregnant women]. Ambulatornaya khirurgiya – Outpatient Surgery, 2 (2), 37-38 [in Russian].

Gurtovoy, B.L., & Grashchenkova, Z.P. (1977). Varikoznoye rasshireniye ven u beremennykh [Varicose veins in pregnant women]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 5, 61-63 [in Russian].

Krylov, A.Yu., Shuludko, A.M, & Khmyrova, S.Ye. (2008). Sovremennyye tendentsii i prognozirovaniye rezultatov lecheniya bolnykh s neoslozhnennymi formami varikoznoy bolezni nizhnikh konechnostey [Current trends and prediction of treatment outcomes in patients with uncomplicated forms of lower limb varicose veins]. Flebologiya – Phlebology, 2, 37-45 [in Russian].

Zolotukhin, I.A., Bogachev, V.Yu., Kuznetsov, A.N., & Kiriyenko, A.I. (2008). Nedostatochnost perforantnykh ven: kriterii i chastota vyyavleniya [Perforating venous insufficiency: criteria and frequency of detection]. Flebologiya – Phlebology, 2, 1, 21-26 [in Russian].

Nazarova, I.B., Samiilenko, V.B., Mushtenko, N.P., & Shembieliev, I.H. (2012). Patolohichne i operatyvne akusherstvo [Pathological and operative obstetrics]. Baskakova, P.M. (Ed.). Kyiv: VSV Medytsyna [in Ukrainian].

Perrin M. (2004). Varikoznaya bolezn nizhnikh konechnostey: endovazalnaya lazernaya i radiochastotnaya koagulyatsiya. Obzor sovremennoy literatury [Varicose disease of the lower extremities: endovasal laser and radiofrequency coagulation. Review of modern literature]. Flebologiya – Phlebology, 7, 39 [in Russian].

Merchant, R., & Jolley, D. (2008). Factors affecting the risk of deep venous occlusion after ultrasound-guided sclerotherapy for varicose veins. European J. Vasc. and Endovasc. Surg., 36, 5, 602-605.

Villavicencio, L. (2002). Khirurgicheskoye lecheniye pervichnogo varikoznogo rasshireniya ven nizhnikh konechnostey: proshloye i nastoyashcheye [Surgical treatment of primary varicose veins of the lower extremities: past and pre­sent]. Flebolimfologiya – Phlebolymphology, 15, 3-11 [in Russian].

Niswander, K., Leyzerovich, G., & Evans, A. (1999). Akusherstvo: Spravochnik Kaliforniyskogo universiteta [Obstetrics: Directory of the University of California]. Moscow: Praktika [in Ukrainian].

Gibbs, Ch.P., & Hawkins, J.L. (2008). Anesteziya u beremennykh s neakusherskoy patologiyey [Anesthesia in pregnant women with non-obstetric pathology]. Meditsina neotlozhnykh sostoyaniy – Medicine of Emergency Conditions, 4 (17), 34-40 [in Russian].

Astakhov, V.A., Svirido, S.V., & Malyshev, A.A. (2014). Modifikatsiya vizualno-analogovoy shkaly dlya otsenki bolevogo sindroma posle obshirnykh abdominalnykh operatsiy [Modification of the visual analogue scale to assess pain after extensive abdominal operations]. Regionalnaya anesteziya i lecheniye ostroy boli – Regional Anesthesia and Treatment of Acute Pain, U11, 1, 26-30 [in Russian].

Jensen, M.P., Chen, C., & Brugger, F.M. (2003). Interpretation of visual analog scale ratings and change scores.a reanalysis of two clinical triials of postoperative pain. J. Pain, 4 (7), 407-414.

Anokhin, P.K. (1975). Uzlovyye voprosy teorii funktsionalnoy sistemy [Key questions of the theory of a functional system]. Moscow: Nauka [in Russian].

Skrypnikov, A.M., Herasymenko, L.O., & Isakov, R.I. (2017). Perynatalna psykholohiia [Perinatal psychology]. Kyiv: Vydavnychyi dim Medknyha [in Ukrainian].

Ancheva, I.A. (2017). Profilaktyka stresu pid chas vahitnosti ta polohiv [Prevention of stress during pregnancy and childbirth]. Zdorovye zhenshchiny – Women’s Health, 5 (12), 32-34 [in Ukrainian].

Zaporozhan, V.M., & Sazonov, O.V. (2012). Profilaktyka stresu u vahitnykh zhinok [Pregnancy stress in pregnant women]. Aktualnye problemy transportnoy medytsyny – Actual Problems of Transport Medicine, 1 (27), 105-109 [in Russian].

Dubosossarskaya, Yu.A., Dubossarskaya, Z.M., Zakharchenko, L.G., & Borovkova, L.G. (2014). Problemy reproduktivnogo zdorovya s pozitsii perinatalnoy psikhologi [Reproductive health problems from the perspective of perinatal psychologists]. Zbirnyk naukovykh prats asotsiatsii akusheriv-hinekolohiv Ukrainy – Collection of Scientific Papers of the Association of Obstetricians-Gynecologists of Ukraine, ½ (33/34), 129-133 [in Russian].

McLeot, R., Fitzgerald, W., & Sarr, M. (2005). McLeot R. Members of the Evidence Based Reviews in Surgery, Canadian Association оf General Surgeons and Americаn College of Surgeons Evidence based Reviews in Surgery. Preoperative tasting for adults to prevent perioperative complicetions. Canadian Journal of Surgery Journal Canadien de Chirurgie, 48 (5), 409-411.

Ljungqvist, O., & Soreide, E. (2003). Preoperative fasting. Br. J. Surg., 90 (4), 400-406. DOI: https://doi.org/10.1002/bjs.4066

Sipos, P., & Ondrejka, P. (2007). “Fast–track” colorectal surgery. Hungarian Medical Journal, 1, 2, 165-174. DOI: https://doi.org/10.1556/OH-HMJ.2007.27996

Published

2019-06-11

How to Cite

Antoniuk-Kysil, V. M., Dzubanovskyi, I. Y., Yenikeeva, V. M., Lincher, S. I., Lypnyi, V. M., & Zhulkevych, I. V. (2019). PLANNED SURGICAL TREATMENT OF PRIMARY SYMPTOMATIC CHRONIC VEIN DISEASE IN PREGNANT WOMEN. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 43–54. https://doi.org/10.11603/24116-4944.2019.1.10179

Issue

Section

OBSTETRICS AND GYNECOLOGY