DIAGNOSTICS AND CORRECTION OF MAGNESIUM DEFICIENCY IN PREGNANT WOMEN WITH BURDENED GYNECOLOGICAL ANAMNESIS

Authors

  • T. P. Andriichuk Kyiv Medical University
  • A. Ya. Senchuk Kyiv Medical University
  • D. A. Martynova Kyiv Medical University

DOI:

https://doi.org/10.11603/24116-4944.2019.1.10172

Keywords:

magnesium, prophylaxis, treatment, preeclampsia, complication

Abstract

The aim of the study – to find patients with clinical signs of magnesium deficiency among pregnant women at risk of developing preeclampsia and study the effectiveness of magnesium preparations use for the prevention of preeclampsia.

Materials and Methods. The examination and complex oral prophylaxis of late gestosis in 100 pregnant women (group I) from the risk group of this complication of pregnancy were provided. The results were compared with the data from the observation of 50 pregnant women (group II) from the risk group of preeclampsia, in whom we did not add magnesium to the prophylaxis complex. The control group (CG) was 50 healthy women with a physiological duration of pregnancy. The presence of magnesium deficiency was determined by the results of the study of survey data recorded in the questionnaire developed by us to study the deficiency of magnesium in pregnant women. Magnesium monoprophylaxis of preeclampsia was carried out with the following drugs:

  1. Magnesium oxide, light 342 mg and magnesium carbonate light 670 mg, which corresponds to 365 mg of ions Mg ++ – 1 tablet per day with intermittent courses – 10–12; 22–26; 30–32 weeks of pregnancy.
  2. Microgranular magnesium oxide powder, 535 mg, corresponding to 300 mg of magnesium and magnesium oxide light 403.0–435.2 mg, which corresponds to 243 mg of magnesium ions. Drugs were prescribed from 10 weeks throughout the pregnancy of 1 tablet once a day.

Results and Discussion. The results of the prophylactic use of oral magnesium preparations showed high efficacy, harmlessness and good tolerability of the proposed therapy, compared with generally accepted approaches (Ministry of Health protocol). In the group of pregnant women who used magnesium preparations (group I), the frequency of the threatened abortion and placental dysfunction was much lower. The effectiveness of the pre-eclampsia prevention was 96.0 % in the group I and only 68.0 % in the group of patients that prevented preeclampsia from the protocol (group II).

Conclusions. It is determined that patients from the risk group of preeclampsia require the administration of magnesium preparations, lifestyle and nutrition corrections. Preventive administration of magnesium preparations in patients at risk of developing preeclampsia is highly effective, harmless and well tolerated. The effectiveness of pre-eclampsia prevention is 96.0 %.

References

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Published

2019-06-11

How to Cite

Andriichuk, T. P., Senchuk, A. Y., & Martynova, D. A. (2019). DIAGNOSTICS AND CORRECTION OF MAGNESIUM DEFICIENCY IN PREGNANT WOMEN WITH BURDENED GYNECOLOGICAL ANAMNESIS. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 38–42. https://doi.org/10.11603/24116-4944.2019.1.10172

Issue

No. 1 (2019)

Section

OBSTETRICS AND GYNECOLOGY

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