STUDY OF BONE TISSUE CHANGES IN CHILDREN WITH CHRONIC GASTRODUODENITIS

Authors

  • I. M. Horishnyi I. Horbachevsky Ternopil State Medical University
  • M. I. Horishnyi I. Horbachevsky Ternopil State Medical University
  • O. M. Mochulska I. Horbachevsky Ternopil State Medical University
  • I. B. Chornomydz I. Horbachevsky Ternopil State Medical University
  • O. B. Synoverska I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/24116-4944.2019.1.10170

Keywords:

osteologic pathology, densitometry, mineral metabolism, alkaline phosphatase, gastroduodenitis

Abstract

The aim of the study – to investigate the biochemical parameters of mineral metabolism and the results of densitometry in children with chronic gastroduodenitis.

Materials and Methods. We examined 30 children with chronic gastroduodenitis aged 5–14 years in the period of exacerbation of the disease, with a disease duration of 1–5 years. In addition to the generally accepted laboratory and instrumental examinations, densitometry was conducted to determine the bone density in the lumbar region of the spine, the content of minerals in the bone in grams, the vertebral area, height and their volume in cubic cm, as well as the biochemical blood test (calcium, phosphorus, magnesium, alkaline phosphatase).

Results and Discussion. Analysis of the data shows that in children with chronic gastroduodenitis, mineral metabolism is disturbed, bone changes develop (osteoporosis or osteosclerosis). With osteoporosis against the backdrop of hypophosphatemia, hypermagneemia, with increased activity of alkaline phosphatase, mineralization of the bone, area and volume of the vertebrae decrease. In osteosclerosis, hypocalcemia, hyperphosphatemia, hypermagneemia with normal enzymatic activity of alkaline phosphatase lead to an increase in bone mineralization, increase in volume and area of ​​the vertebrae.

Conclusion. The results of the studies showed the presence of signs of osteoporosis and osteosclerosis against the background of disturbed mineral metabolism, depending on the activity of alkaline phosphatase, indicating the need to find correction of the detected changes.

References

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Published

2019-06-11

How to Cite

Horishnyi, I. M., Horishnyi, M. I., Mochulska, O. M., Chornomydz, I. B., & Synoverska, O. B. (2019). STUDY OF BONE TISSUE CHANGES IN CHILDREN WITH CHRONIC GASTRODUODENITIS. Actual Problems of Pediatrics, Obstetrics and Gynecology, (1), 15–18. https://doi.org/10.11603/24116-4944.2019.1.10170

Issue

No. 1 (2019)

Section

PEDIATRICS

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