COAGULATING POTENTIAL OF BLOOD IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE OF PROFESSIONAL ETIOLOGY OF VARIOUS SEVERITY

Authors

  • V. V. Ivchuk UKRAINIAN SCIENTIFIC RESEARCH INSTITUTE OF INDUSTRIAL MEDICINE, KRYVYI RIH
  • T. Yu. Kopteva UKRAINIAN SCIENTIFIC RESEARCH INSTITUTE OF INDUSTRIAL MEDICINE, KRYVYI RIH
  • T. A. Kovalchuk UKRAINIAN SCIENTIFIC RESEARCH INSTITUTE OF INDUSTRIAL MEDICINE, KRYVYI RIH

DOI:

https://doi.org/10.11603/mcch.2410-681X.2018.v0.i3.9586

Keywords:

chronic obstructive pulmonary disease, professional etiology, hemostasis, coagulation

Abstract

Introduction. Chronic obstructive pulmonary disease (COPD) of professional etiology, which is accompanied not only by changes in the respiratory tract, but also by changes in the hemostatic system takes an important place among diseases of the respiratory system.

The aim of the study – to evaluate the system of blood coagulation in COPD of a professional etiology of various severity.

Research Methods. The results of studies of capillary and venous blood of 112 workers of the mining industry with COPD with various severity were analyzed. Among the patients, 34 people had stage I disease, 40 people – stage II, 38 people – stage III, 29 practically healthy persons made up a control group. The state of the hemostatic system was assessed by the following parameters: platelet count, fibrinogen concentration, activated partial thromboplastin time, thrombin time, international normalized ratio, prothrombin index, prothrombin ratio.

Results and Discussion. An analysis of the prothrombin profile indicates that the levels of coagulation cascade factors change in stage II-III COPD patients, which indicates a disruption in the external link of the blood coagulation system. With increasing severity of COPD of professional etiology, changes in the levels of coagulation cascade factors indicated abnormalities of the hemostatic system in the direction of hypercoagulation and depression of the fibrinolytic potential of the blood.

Conclusions. During the course of COPD of professional etiology, there are violations in the coagulation unit of hemostasis towards hypercoagulability together with an increase in the severity of the disease. Disturbance of the coagulation unit of hemostasis in patients with COPD of professional etiology occurs mainly along the external path of blood clotting.

 

References

Kreuter, M., Wijsenbeek, M.S., Vasakova, M., Spagnolo, P., Kolb, M., Costabel, U., ... & Maher, T.M. (2016). Unfavorable effects of medically indicated oral anticoagulants on survival in idiopathic pulmonary fibrosis. European Respiratory Journal, 47 (6), 1776-1784.

Snow, S.J., Cheng, W., Wolberg, A.S., & Carra­way, M.S. (2014). Air pollution upregulates endothelial cell procoagulant activity via ultrafine particle-induced oxidant signaling and tissue factor expression. Toxicological Sciences, 140 (1), 83-93.

White, H., Bird, R., Sosnowski, K., & Jones, M. (2016). An in vitro analysis of the effect of acidosis on coagulation in chronic disease states – a thromboelastograph study. Clinical Medicine, 16 (3), 230-234.

Fruchter, O., Yigla, M., & Kramer, M.R. (2015). D-dimer as a prognostic biomarker for mortality in chro­nic obstructive pulmonary disease exacerbation. The Ame­rican Journal of the Medical Sciences, 349 (1), 29-35.

Sneeboer, M.M., Majoor, C.J., de Kievit, A., Meijers, J.C., van der Poll, T., Kamphuisen, P.W., & Bel, E.H. (2016). Prothrombotic state in patients with severe and prednisolone-dependent asthma. Journal of Allergy and Clinical Immunology, 137(6), 1727-1732.

Cantin, A.M., Hartl, D., Konstan, M.W., & Chmiel, J.F. (2015). Inflammation in cystic fibrosis lung disease: pathogenesis and therapy. Journal of Cystic Fibrosis, 14 (4), 419-430.

Levina, E.V., Ivchuk, V.V., & Rubtsov, R.V. (2017). Praktychna tsinnist vyznachennia pokaznykiv erytro­tsytarnoho riadu u khvorykh na HOZL profesiinoi etiolohii [The practical value of determining the erythrocyte series in patients with COPD of professional etiology]. Mir meditsiny i biologii – World of Medicine and Biology, 13 (4), (62), 50-53 [in Ukrainian].

Ugurlu, E., Kilic-Toprak, E., Can, I., Kilic-Erkek, O., Altinisik, G., & Bor-Kucukatay, M. (2017). Impaired hemorheology in exacerbations of COPD. Canadian Respiratory Journal, 88 (3), 32-35.

Smith, I., Pearse, B. L., Faulke, D. J., Naidoo, R., Nicotra, L., Hopkins, P., & Ryan, E.G. (2017). Targeted bleeding management reduces the requirements for blood component therapy in lung transplant recipients. Journal of Cardiothoracic and Vascular Anesthesia, 31 (2), 426 433.

Gohy, S.T., Hupin, C., Pilette, C., & Ladjemi, M.Z. (2016). Chronic inflammatory airway diseases: the central role of the epithelium revisited. Clinical & Experimental Allergy, 46 (4), 529-542.

Published

2018-11-13

How to Cite

Ivchuk, V. V., Kopteva, T. Y., & Kovalchuk, T. A. (2018). COAGULATING POTENTIAL OF BLOOD IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE OF PROFESSIONAL ETIOLOGY OF VARIOUS SEVERITY. Medical and Clinical Chemistry, (3), 96–100. https://doi.org/10.11603/mcch.2410-681X.2018.v0.i3.9586

Issue

Section

ORIGINAL INVESTIGATIONS