The features of endogenous intoxication syndrome indices in rabbits with mechanical non-penetrating corneal trauma and ways of its correction
DOI:
https://doi.org/10.11603/mcch.2410-681X.2018.v0.i2.9142Keywords:
mechanical non-penetrating trauma, cornea, endogenous intoxication.Abstract
Introduction. Eye injury is one of the urgent problems of modern ophthalmology, due to the high frequency, severity and polymorphism of clinical manifestations. Complete rehabilitation, full rehabilitation, reduced visual acuity due to eye injury are largely dependent on correction of disturbed functions.
The aim of the study – to find out the peculiarities of the corrective effect of the preparation created on the basis of biological raw material – the concentrate of the deproteinized dermal layer of pig skin, on indices of endogenous intoxication syndrome in rabbits in the dynamics of mechanical non-penetrating corneal injury.
Research Methods. The research was carried out on the sexually mature rabbits of the "Chinchilla" breed, which modeled a mechanical nonpenetrating corneal injury and corrected by Efial and Solcoseril preparations. The content of medium weight molecules in serum, as markers of the endogenous intoxication syndrome, was determined by the method of R. I. Lifshitz and co-authors.
Results and Discussion. In rabbits with a simulated non-penetrating mechanical trauma to the cornea, an increase in the level of endogenous intoxication has been observed, indicating an increase in the content of medium molecules in serum. Comparing the effectiveness of corrective factors, it was found that the use of Efial with mechanical non-penetrating corneal injury leads to a statistically significant decrease in the incidence of endogenous intoxication in the post-traumatic period in 10 days – by 7.5 % (p<0.02) and after 14 days – by 16.7 % (p<0.001).
Conclusions. Application to animals, which was modeled mechanical damage to the cornea of eye drops "Efial" and eye gel "Solcoseril" positively influenced the indices of endogenous intoxication since the 3rd day of the experiment. The correction of the deproteinized dermal layer of the pig's skin is probably more effective with respect to the action of the reference preparation of deproteinized hemoderivate from the blood of calves, especially after the 10th day of the experiment.
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