The influence of the apple pectin on some biochemical and hematological parameters of alcoholated animals
DOI:
https://doi.org/10.11603/mcch.2410-681X.2018.v0.i1.8882Keywords:
pectin, acute alcohol intoxication, biochemical and hematological parameters.Abstract
Introduction. the problem of acute and chronic alcohol intoxications is worldwide because of related injury and high mortality. Medical record protocols include absorbents among other medicines used in treatment of such poisonings.
The aim of the study – to investigate the effect of apple pectin on hematological and some biochemical parameters of blood serum in acutely alcoholated rats and compare it with standard enterosorbents used in the clinic for acute alcohol poisoning.
Recearch Methods. Experiments were conducted on 65 white outbred rats weighing 180–200 g, which were modeled acute alcohol intoxication by introducing into the stomach 40 % solution of ethanol in a dose of 2 ml/100 g body weight. The influence of apple pectin (in dose 0.2 g/100 g of body weight),and referenceagents (activated charcoal and silicon dioxide – 0.25 g and 0.05 g/100 g respectively) on biochemical and hematological parameters was estimated by changes in hemoglobin levels and the number of erythrocytes, glucose, cholesterol, and transaminase activity in serum.
Results and Discussion. It was found that apple pectin when given in the stomach 30 min. before and an hour after the introduction of ethanol normalizes the level of red blood cells and hemoglobin (p˃0.05 compared to intact and other treated groups, but exceeded the level of those indicators by 18.5 % and 15.6 % in untreated animals respectively), improves the lipid (cholesterol) and hydrocarbon (glucose) metabolism and reduces the hepatocytecytolysis: the use of apple pectin in alcoholated rats lowered the activity of AsAT by 19.4 % and activity of AlAT by 16.6 % versus in treated with activated charcoal animals. At the same time mentioned effects were equated with those for the use of “white coal”.
Conclusion. According to the determined indicators, the efficiency of pectin is equal to standard adsorbents used as reference products, and in some cases, predominates them.
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