The indices of metabolismin rats with periodontitis on the background of hyper- and hypothyroidism
DOI:
https://doi.org/10.11603/mcch.2410-681X.2017.v0.i4.8414Keywords:
periodontitis, thyroid hormones, metabolism.Abstract
Introduction. The multifaceted action of thyroid hormones on the rate of metabolic processes reflected on the tissues of periodontium has been known for a long time. In this case, the prevalence of periodontitis in the population, the complexity of the implementation of prevention and treatment of the disease, ambiguity in the interpretation of the main pathogenetic mechanisms makes this problem extremely relevant.
The aim of the study – to learn the indices of metabolismin blood serum of rats with periodontitis without concomitant pathology and against the background of hyper- and hypothyroidism.
Research Methods. The study was carried out on 48 white non-linear male rats. Determination of glucose, total protein, albumin, urea, creatinine, total cholesterol, α-cholesterol and β-cholesterol in serum was carried out on a semi-automatic biochemical analyzer Humalyzer 2000 (Human, Germany).
Results and Discussion. Experimental periodontitis is accompanied by a decrease in the concentration of glucose in the blood serum, hypoalbuminemia, an increase in the concentration of urea, total cholesterol, β-cholesterol and a decrease in the concentration of α-cholesterol. The imbalance of thyroid hormones has a multifaceted effect on metabolism in experimental periodontitis. Thus, in rats with periodontitis in case of hyperthyroidism, the concentration of glucose and total protein increased, albumin concentration decreased, urea concentration increased, total cholesterol and α-cholesterol concentrations decreased, and no significant changes in β-cholesterol concentration were observed. In rats with periodontitis, combined with hypothyroidism, glucose concentration decreased, total protein concentration increased, albumin concentration decreased, urea concentration increased, total cholesterol and β-cholesterol concentrations increased, and the concentration of α-cholesterol decreased.
Conclusions. Reasonable changes in all major spectra of metabolism – carbohydrate, protein and lipid in case of experimental periodontitis indicate that periodontitis is a local process that affects the general state of the organism. The imbalance of thyroid hormones has a pronounced effect on the overall metabolic processes, especially on proatherogenic changes in serum, which are more pronounced in case of an experimental periodontitis in the background of hypothyroidism.
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