The state of free-radical oxidation and antioxidant system at the experimental acute peritonitis associated with hypothyroidism
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7251Keywords:
extensive peritonitis, hypothyroidism, free-radical oxidation, antioxidant system.Abstract
To study the influence of hypothyroidism on the course of free-radical processes and state of antioxidant system in rats with acute extensive peritonitis, the production of active forms of oxygen by mononuclear leukocytes, concentration of lipid hydroperoxides, TBA-active products, Schiff bases, SOD and catalase activity were determined. Simulation of extensive peritonitis with associated hypothyroidism led to the less obvious, than in euthyroid rats, increase of active forms of oxygen and lipid peroxidation products. Although the reduction of activity of enzymes of the first line of antioxidant defense (superoxide dismutase and catalase) was more evident.
References
Rasprostranennyi gnoinyi peritonit / V. V. Boiko, I. L. Krivoruchko, S. I. Teslenko, A. V. Sivozhelezov. – Kh. : Prapor, 2008. –278 s.
Dziubanovskyi I. Ia. Syndrom poliorhannoi nedostatnosti ta yoho korektsiia u khvorykh na hostryi poshyrenyi perytonit / I. Ia. Dziubanovskyi, B. O. Mihenko // Ukrainskyi Zhurnal Khirurhii. – 2009. – № 2. – S. 56–59.
Dudin V. I. Kolorimetricheskoe opredelenie perekisi vodoroda pri izmerenii aktivnosti katalazy v krovi / V. I. Dudin // Probl. biologii produktivnykh zhivotnykh. – 2008. – № 2. – S. 96–99.
Kolesova O. E. Perekisnoe okislenie lipidov i metody opredeleniia produktov lipoperoksidatcii v biologicheskikh sredakh / O. E. Kolesova, A. A. Markin, T. N. Fedorova // Lab. delo. – 1984. – № 9. – S. 540–546.
Lapach S. N. Statisticheskie metody v mediko-biologicheskikh issledovaniiakh s ispolzovaniem Excel / S. N. Lapach, A. V. Chubenko, P. N. Babich. – K. : Morion, 2000. – 320 s.
Makarevich O. P. Aktivnost superoksiddismutazy krovi v ostryi period razlichnykh zabolevanii / O. P. Makarevich, P. P. Golikov // Lab. delo. – 1983. – № 6. – C. 24–27.
Naukovo-praktychni rekomendatsii z utrymannia laboratornykh tvaryn ta roboty z nymy / Iu. M. Kozhem’iakin, O. S. Khromov, M. A. Filonenko, H. A. Saifetdinova. – K. : Avitsena, 2002. – 156 s.
Eksperimentalnaia model rasprostranennogo kalovogo peritonita / V. A. Lazarenko, V. A. Lipatov, Iu. Iu. Blinkov, D. V. Skorikov // Chelovek i ego zdorove. – 2008. – № 4. – S. 128–132.
Pankіv V. І. Sindrom gіpotireozu / V. І. Pankіv // Mezhdunar. endokrin. zhurn. – 2012. – № 5 (45). – S. 136–148.
Pro- i antioksidantnaia sistema u bolnykh gipo¬tirozom i ee izmeneniia pod vliianiem preparatov lipoevoi kisloty / A. S. Ametov, E. S. Belonozh¬kina, I. I. Pavliuchenko, A. A. Basov // Probl. endokrinologii. – 2007. – 53, № 2. – S. 49–54.
Petrosian E. A. Sostoianie pro- i antioksidantnoi sistem krovi pri eksperimentalnom zhelchnom peritonite / E. A. Petrosian, V. I. Sergienko, A. A. Sukhinin // Biul. eksperim. biol. i med. – 2005. – 139, № 1. – S. 19–21.
Stalnaia I. D. Metod opredeleniia malonovogo dialdegida s pomoshchiu tiobarbiturovoi kisloty / I. D. Stalnaia, T. G. Garishvili // Sovremennye metody v biokhimii / pod red. V. N. Orekhovicha. – M. : Meditcina, 1977. – S. 66–68.
Khyshiktuev B. S. Metody opredeleniia produktov perekisnogo okisleniia lipidov v kondensate vydykhaemogo vozdukha i ikh klinicheskoe znachenie / B. S. Khyshiktuev, N. A. Khyshiktueva, V. N. Ivanov // Klinich. lab. diagnostika. – 1996. – № 3. – S. 13–15. Blot S. Critical issues in the clinical management of complicated intraabdominal infections / S. Blot, J. J. De Waele // Drugs. – 2005. – No. 65 (12). – Р. 1611–1620.
Thyroid hormone regulation of cell migration and oxidative metabolism in polymorphonuclear leukocytes: clinical evidence in thyroidectomized subjects on thyroxine replacement therapy / F. Marino, L. Guasti, M. Cosentino [et al.] // Life Sci. – 2006. – 78, No. 10. – P. 1071–1077.
Pross M. Reduced neutrophil sequestration in lung tissue after laparoscopic lavage in a rat peritonitis model / M. Pross, R. Mantke, D. Kunz // World J. Surg. – 2002. – 26, No. 1. – P. 49–53.
M. Reed Acute Bacterial Peritonitis in Adults / M. Reed, K. Parbadia, J. Cherian // US Pharm. – 2012. – 37 (12). – P. HS1–HS8.
