SERTRALINE AS AN OBJECT OF CHEMICAL-TOXICOLOGICAL ANALYSIS (LITERATURE REVIEW)

Abstract

Introduction. Depression is a widespread mental disorder and one of the main factors that causes the global population to fall ill. According to the World Health Organization, depression is another leading cause of disability in the world, according to forecasts, from the first place until 2030. It is estimated that 4 % of the population suffers from depression – that’s about 332 million people in the world. Pharmacotherapy with prescribed antidepressants is no longer the basic method of treating depression, regardless of its nosological form. The choice of a specific drug is based on the particularities of the clinical and psychopathological structure of depressive disorder. Sertraline is one of the current antidepressants in the class of selective serotonin replenishment inhibitors (SSRIs), which are widely used for the treatment of depressive disorders, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder and social phobia. The drug is characterized by high efficiency and a remarkably favorable safety profile, which means it is widely used in medical practice both abroad and in Ukraine. The method of studying sertraline from the chemical-toxicological aspect is the analysis of its pharmacological and toxicological effects, the peculiarities of metabolism and the mechanisms of development of side and toxic effects, as well as assessment of the risks of overdose and drug interactions. What is directly important is the development and improvement of methods for the clear and acidic extraction of sertraline and its metabolites in biological objects, which leads to increased efficiency of laboratory diagnostics acute symptoms, control of therapeutic concentrations and assessment of toxicological risks when combined with other psychoactive substances. The aim of this study is to systematize and analyze current approaches to the identification and quantitative determination of pregabalin in various types of research objects. Conclusions. The review of scientific sources indicates that the development and validation of new analytical and bioanalytical methods, as well as the optimization of existing ones – particularly methods for the isolation of pregabalin from various matrices – remain relevant tasks in chemical-toxicological analysis and pharmaceutical control.