COMORBID COURSE OF TYPE 2 DIABETES MELLITUS AND PATHOLOGIES OF THE THYROID GLAND: LABORATORY MARKERS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2021.i4.12651Keywords:
type 2 diabetes mellitus, hypothyroidism, diffuse non-toxic goiter, laboratory dataAbstract
Introduction. Diabetes and its complications are among the top 10 causes of death in the world. Most patients with type 2 diabetes (T2DM) have at least one complication. Thyroid dysfunction (TD), after diabetes, is the second most common metabolic dysfunction in the world. In recent years, researchers have paid more attention to the comorbid course of diabetes mellitus and TD. Hypothyroidism (HT) and diffuse non-toxic goiter are common thyroid disorders.
The aim of the study – to identify possible laboratory markers of comorbid T2DM, HT and diffuse non-toxic goiter.
Research Methods. A retrospective study of the medical records of 519 patients with T2DM who were hospitalized in the endocrinology department in 2019 was conducted. Two research groups were formed: group 1 (501 patients with type 2 diabetes mellitus) and group 2 (19 patients with comorbid T2DM, HT and diffuse non-toxic goiter). Laboratory data (results of general blood tests, lipid profile, thyroid hormones, biochemical markers) were evaluated and statistical processing was performed using the calculation of median, lower and upper quartiles, Mann-Whitney U-test.
Results and Discussion. The study of general blood tests revealed significantly higher ESR (p = 0.03834), BMI (p = 0.0009), glycated hemoglobin (p = 0.0009), AST (p = 0.01379) in the group T2DM + HT + diffuse non-toxic goiter compared with the group T2DM only. Also, patients with comorbid T2DM, HT and diffuse non-toxic goiter had dyslipidemia due to HDL cholesterol (p = 0.0003), residual cholesterol (p = 0.0003) and triglycerides (p = 0.0084) compared with patients with T2DM without TD.
Conclusions. Patients with comorbid T2DM, HT and diffuse non-toxic goiter have significantly higher BMI, glycated hemoglobin, AST, ESR compared to patients with T2DM only. There is also a violation of lipid metabolism, characterized by a significantly decrease HDL cholesterol, increased residual cholesterol and triglycerides.
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