COAGULATING POTENTIAL OF BLOOD IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE OF PROFESSIONAL ETIOLOGY OF VARIOUS SEVERITY
Introduction. Chronic obstructive pulmonary disease (COPD) of professional etiology, which is accompanied not only by changes in the respiratory tract, but also by changes in the hemostatic system takes an important place among diseases of the respiratory system.
The aim of the study – to evaluate the system of blood coagulation in COPD of a professional etiology of various severity.
Research Methods. The results of studies of capillary and venous blood of 112 workers of the mining industry with COPD with various severity were analyzed. Among the patients, 34 people had stage I disease, 40 people – stage II, 38 people – stage III, 29 practically healthy persons made up a control group. The state of the hemostatic system was assessed by the following parameters: platelet count, fibrinogen concentration, activated partial thromboplastin time, thrombin time, international normalized ratio, prothrombin index, prothrombin ratio.
Results and Discussion. An analysis of the prothrombin profile indicates that the levels of coagulation cascade factors change in stage II-III COPD patients, which indicates a disruption in the external link of the blood coagulation system. With increasing severity of COPD of professional etiology, changes in the levels of coagulation cascade factors indicated abnormalities of the hemostatic system in the direction of hypercoagulation and depression of the fibrinolytic potential of the blood.
Conclusions. During the course of COPD of professional etiology, there are violations in the coagulation unit of hemostasis towards hypercoagulability together with an increase in the severity of the disease. Disturbance of the coagulation unit of hemostasis in patients with COPD of professional etiology occurs mainly along the external path of blood clotting.
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