Influence of iodine on the indicators of lipid profile of rats’ blood of different age in experimental obesity

  • N. H. Kopchak I. Puliui Тernopil National Technical University
  • О. S. Pokotylo I. Puliui Тernopil National Technical University
  • M. D. Kuhtyn I. Puliui Тernopil National Technical University
  • M. I. Koval I. Hobrachevsky Тernopil State Medical University
Keywords: blood serum, cholesterol, triglycerides, lipoproteins, Jodis-Concentrate, Iodomarine, obesity.


Introduction. Today, obesity is an extremely common phenomenon that negatively affects on the functional state of the organism, metabolism, and this in turn leads to the increase of a number of diseases. The thyroid gland has a significant effect on lipid metabolism, and especially negative in the case of iodine deficiency in the diet, which leads to hypothyroidism. Comparative study of the effect of various iodine-derived lipid metabolism in obesity is perspective.

The aim of the study – to investigate the comparative affect of biologically active iodine in the composition of “Jodis-Concentrate” and inorganic iodine (J-C) as a part of “Iodomarine” on the indicators of lipid metabolism in blood of white male rats with experimental alimentary obesity.

Research Methods. The object of the study was the blood serum of white rats, and the subject – separate indicators of lipid metabolism in it. The study was conducted on 48 white male rats. Animals were divided into 3 age groups of 16 animals in each: 1st group – 1.5 months; 2nd – 2.5 months; 3rd – 5th month. In each age group there were 4 subgroups of 4 animals: 1st – control, had a typical diet; 2nd, 3rd and 4th subgroup were with experimental alimentary obesity (EAO), which was formed through the inductor food craving – the sodium salt of glutamic acid in a ratio of 0.6 : 100.0 and high-calorie diet that included standard meals (47 %), sweet condensed milk (44 %), corn oil (8 %) and vegetable starch (1 %). Daily for 45 days, animals of the 3rd subgroup received biologically active iodine in the composition of “Jodis-Concentrate” (J-C) as of 0.1 ml (0.4 mcg of iodine) per kg of body weight a day and 4th subgroup were intragastric administered in the form of inorganic iodine as potassium iodide in medicine “Iodomarin” (IM) as of 0.4 mcg of potassium iodide per kg of body weight a day. In the serum blood, the content of total lipids, total cholesterol, triglycerides, high and low density lipoprotein were determined.

Results and Discussion. The obtained results suggest that with the help of biologically active iodine in the composition of “Jodis-Concentrate” there was a significant decrease of the content of common lipids, triglycerides, total cholesterol, low density lipoprotein in blood serum of males with different age than with “Iodomarin”.

Conclusions. Given the effective results of the study of the hypolipidemic effect of J-C it is advisable to use it as a preventive and therapeutic agent for reducing the content of common lipids of triglycerides, total cholesterol, and low density lipoproteins in the blood.

Author Biography

N. H. Kopchak, I. Puliui Тernopil National Technical University


Voronenko, N.Yu. (2013). Metabolichnyi syndrom ta dysfunktsiia zhyrovoi tkanyny u zhinok [Metabolic syndrome and dysfunction of adipose tissue in women]. Zdorovye zhenshchyny – Women’s Health, 5, 66-71 [in Russian].

Nechyporuk, V.M. & Korda, M.M. (2015). Metabolizm pry hipo- ta hipertyreozi [Metabolism in hyperthyroid hypertension]. Visnyk naukovykh doslidzhen – Journal of Scientific Researches, 3, 4-7. DOI 10.11603/1681-276Х.2015.3.5170 [in Ukrainian].

Chung, H.R. (2014). Iodine and thyroid function. Annals of Pediatric Endocrinology & Metabolism, 8-12. doi:106065/apem.2014.19.1.8 4. Ramachandran, K., Ebenezer, W., Thangapaneer, S. & Shyam, K. (2014). Relationship between lipoprotein(a) and thyroid hormones in hypothyroid patients. Journal of Clinical and Diagnostic Research, 2, 37-39. DOI: 10.7860/JCDR/2014/7817.4001

Yuzvenko, T.Yu. Vzaiemozviazok mizh hipotyreozom ta ozhyrinniam [Interrelation between hypothyroidismand obesity]. Mizhnarodnyi endokrynolohichnyi zhurnal –International Endocrinology Journal, 8, 11-14 [in Ukrainian].doi: 10.22141/2224-0721.8.80.2016.89530

Desai, J., Vachhani, U.N., Modi, G. & Chauhan K. (2015). A study of correlation of serum lipid profile in patients with hypothyroidism. International Journal of Medical Science and Public Health, 8, 1108-1112. Doi:


Rizos, C.V., Elisaf, M.S. & Liberopoulos, E.N. (2011). Effects of thyroid dysfunction on lipid profile. The Open Cardiovascular Medicine Journal, 5, 76-84. doi:10.2174/1874192401105010076

Marushchak, M.I., Mialiuk, O.P., Hevko, U.P., Habor, H.H., Yaroshenko, T.Ya. & Antonyshyn, I.V. (2017). Analiz potentsialu systemy hlutationu u shchuriv z alimentarnym ozhyrinnіam [Analysis of glutathione system potential in rats with alimentary obesity]. Medychna ta klinichna khimiia – Medical and Clinical Chemistry, 2, 60-65. doi 10.11603/mcch.2410-681X.2017.v0.i2.7972

[in Ukrainian].

Longhi, S. & Radetti G. (2013). Thyroid function and obesity. J. Clin. Res. Pediatr. Endocrinol., 5, 40-44. doi: 10.4274/Jcrpe.856

Nykolyshyn, L.V. (2014). Osoblyvosti lipidnoho spektru krovi, mikroelementnoho balansu pry hipotyreoidnii dysfunktsii ta mozhlyvi shliakhy korektsii [Features of lipid blood spectrum, microelement balance in hypothyroid dysfunction and possible ways of correction]. Halytskyi likarskyi visnyk – Galician Medicinal Journal, 1, 49-53 [in Ukrainian].

Kalinouskауа, E.I., Kuznetsova, I.V., Hapaluk, A.V., Kondrashova, S.B., Pavlovets, L.V., Blagun, E.V., … Derevyanko, I.A. (2015). Morfologicheskye

osobennosti porazheniya mykrotsyrkulyatornogo rusla i kharakter izmeneniya urovnya hormona zhyrovoy tkani vysfatina u krys na modely alimentarnogo ozhyreniya [Morphological features of the damage of microvasculature

and changes in the levels of adipose tissue hormone visfatin in rat model of alimentary obesity]. Grodnenskiy gosudarstvennyy meditsynskiy universitet – Grodno State Medical University, 4, 48-53 [in Russian].

Marushchak, M.I., Antonуshуn, I.V., Mіalіuk, O.P., Orel, Yu.M. & Krуnуtska, I.Ya. (2013). Sposіb modeliuvannia alіmentarnoho ozhуrіnnia [The method of modeling of alimentary obesity]. Patent Ukraina, № u 2013 12044, 2014 [in Ukrainian].

Kamyshnikov, V.S. (2004.). Spravochnik po kliniko-biokhimicheskim issledovaniyam i laboratornoy diagnostike [Reference book on clinical and biochemical research and laboratory diagnostics]. Moscow: MEDpress-

inform [in Russian].

Kok-Yong, C., Soelaiman, I., Mohamed, I.N., Aminuddin, A., Johari, M.H., Zurinah, W. & Ngah, W. (2014). The relationships between thyroid hormones and thyroid-stimulating hormone with lipid profile in euthyroid

men. Int. J. Med. Sci., 4, 349-355. doi:10.7150/ijms.7104

How to Cite
Kopchak, N., PokotyloО., Kuhtyn, M., & Koval, M. (2018). Influence of iodine on the indicators of lipid profile of rats’ blood of different age in experimental obesity. Medical and Clinical Chemistry, (4), 123-128.