MORPHOLOGICAL AND METABOLIC CHANGES CAUSED BY SYNDROME OF ISCHEMIA-REPERFUSION, AND FEATURES OF ITS THERAPEUTIC INFLUENCE
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i4.9733Keywords:
ischemia, ischemia-reperfusion, bleeding, tourniquet, skeletal muscle, experiment, necrosis, apoptosisAbstract
The article analyzes literary sources regarding the causes and characteristics of the development of ischemia-reperfusion syndrome, as well as manifestations of pathophysiological changes under the influence of environmental factors. The influence of treatment and prophylactic measures aimed at reducing the damage is investigated.
An influx of oxygenated blood which contains nutrients is imperative for the nutrition of each organ. Ischemia, being a condition of limiting or stopping of blood supply, has many causes – acute and chronic.
Changes that cause ischemia can develop for decades (cardiovascular and cerebrovascular diseases). There are also those that arise against the backdrop of a relatively short period of time and are associated with a sudden cessation of blood supply (embolism, thrombosis, long-term compression syndrome and one of its variants – complications arising from the use of a hemostatic tourniquet, as well as a tourniquet for blood supply stoppage in organ during surgery).
The type of ischemia that leads to the restoration of blood flow, causes a special phenomenon, when restoring the blood supply of ischemic tissue and it leads also to quite expressed tissues' damage than those that occur on the background of isolated ischemia. This phenomenon is called the syndrome of ischemia-reperfusion. Acute limb ischemia has such symptoms as pain, edema, loss of function and violation of nerve condition. But in complicated state it can cause damaging of the whole body.
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