APPLICATION OF NEUROPHYSIOLOGICAL BRAIN REACTION WHEN FORMING PREVENTIVE "ISCHEMIC TOLERANCE" (PRE- AND POST-CONDITIONING) FOR THE TREATMENT AND REHABILITATION OF PATIENTS WITH POSTSTROKE PSYCHOPATHOLOGICAL DISORDERS

Abstract

According to the WHO, more than 1 million people suffer from stroke annually. Most often, there are ischemic strokes (87 %), rarely – hemorrhagic (10 %) or strokes from the circulation in subarachnoid space (3 %).
The phenomenon of "ischemic tolerance" was introduced by K. Kitagawa in 1990 when describing the protective effect of small doses of cerebral hyperthermia (+ 35 ºС) from the action of significantly more pronounced stimuli. For the first time such an effect was foreseen by S. P. Botkin (1867), applied at hypoxia of the myocardium S. M. Marri et al. in 1986; he was called "pre-and post-conditioning".

The aim – to investigate the therapeutic efficacy of the use of so-called "ischemic tolerance" in 48 patients with different psychopathological symptoms that occurs after a stroke.

Material and Methods. A study was conducted on 48 male patients with post-stroke psychiatric disorders in the form of various psychopathological symptoms.

Conclusions. The use of weak craniocerebral hypo and hyperthermia (+ 35 ºС–37.5 ºС) created the effect of "ischemic tolerance" in the brain tissue and, along with inhalation of xenon and the introduction of neuroprotectors, cerebrolysin (10.0 mg) and valproate (400–800 mg), led to the practical disappearance of post-stroke psychopathological symptomatology.