TRIGLYCERIDES-GLUCOSE INDEX AS A SURROGATE MARKER OF INSULIN RESISTANCE IN PATIENTS WITH CORONARY ARTERY DISEASE, OVERWEIGHT AND OBESITY

Abstract

There are many methods for evaluating insulin resistance (IR), but they have some disadvantages and high price. The Triglyceride-Glucose Index is a simple and clinically useful surrogate marker for insulin resistance, suitable for screening.

The aim: to evaluate the triglyceride-glucose index in patients with coronary artery disease and obesity, depending on insulin resistance; analyze correlations in the group of observed patients.

Material and Methods. The study included 107 patients with coronary artery disease, overweight or obesity. In all patients, glucose, insulin, HOMA-IR, HbA1c, lipids, uric acid and transaminases levels was measured, and calculated triglyceride-glucose indexes.

Patients were divided into 2 groups, depending on the level of HOMA-IR, insulin-resistance were patients who have HOMA-IR>1.7. Correlation analysis was performed in the whole population of patients.

Results. There were significantly higher glucose, insulin, triglycerides and uric acid levels in the group of patients with IR. A significantly higher triglyceride-glucose index in patients with insulin resistance and significant moderate positive relationship between HOMA-IR index and triglyceride-glucose index was identify.

Conclusions. The triglyceride-glucose index is a surrogate marker of insulin resistance, an accessible screening method for the identification of patients in need of an in-depth examination of glucose metabolism and its correction.