ASSOCIATION OF METABOLIC AND GENETIC MARKERS IN THE RISK OF DEVELOPMENT OF OSTEOPENIC CONDITIONS IN COMBINING CHRONIC PANCREATITIS AND HYPERTENSIVE DISEASE
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i2.8585Keywords:
chronic pancreatitis, hypertensive disease, vitamin D receptor gene, osteocalcin.Abstract
In the current research, 70 patients with chronic pancreatitis (CP) and hypertensive disease (HD) were examined for the role of the vitamin D receptor gene during these diseases. It was found out that the comorbidity of nosological forms was more often observed in persons with the V-allele of polymorphism of the VDR gene (84.3 %), unlike the control (75.7 %) and the group of patients with isolated CP (77.5 %). Also, with CP and HD, osteoporotic changes were most often formed (27.3 %), in contrast to the comparison group, where there were 10 % of such patients. Significant changes are shown in osteocalcin content indicators, which depend on the polymorphism of the VDR gene.
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