CLINICAL CHARACTERISTICS OF GASTROESOPHAGEAL REFLUX DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE 2
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i2.8484Keywords:
gastroesophageal reflux disease, diabetes mellitus type 2.Abstract
The aim of the study – to learn the clinical features of gastroesophageal reflux disease (GERD) in patients with diabetes mellitus type 2.
Material and Methods. 84 patients with diabetes mellitus type 2 with concomitant gastroenterological pathology (gastroesophageal reflux disease (GERD)) were examined from 2016 to 2017 on the basis of Propaedeutics of Therapy Department of the Medical Faculty, State University “UzhNU” (Gastroenterological and Endocrinology Department of the Transcarpathian Regional Hospital named after A. Novak). All patients were examined using anthropometric, general clinical, laboratory, and instrumental research methods. Diabetes mellitus type 2 diagnosis is based on the recommendations of the International Diabetes Federation (IDF, 2005). The diagnosis of GERD was based on the criteria of the unified clinical protocol (Order of the Ministry of Health of Ukraine dated from October 31, 2013 No. 943).
Results. Patients with diabetes mellitus type 2 of medium severity were involved to the study. The analysis of the anthropometric indicators showed that all examined patients with diabetes mellitus type II had an overweight or obesity of various degrees, namely, an overweight was observed in 46 (54.7 %) patients, and obesity of different degrees – in 38 (45.3 %) of patients with diabetes mellitus type 2. The typical complaints for GERD were detected in 56 (66.7 %) patients with diabetes mellitus type 2. The main clinical manifestation of GERD in patients was sneezing, heartburn, lump in the throat, and dysphagia. Sore throat, hoarse voice, and complaints of dry, barking cough were observed in 13.1 % of the patients. The presence of retrosternal pain along the esophagus and violation of heart functioning were examined in 20.2 % of the patients who previously were consulted by cardiologist. The GERD diagnosis was confirmed by endoscopic examination of all 84 patients with diabetes mellitus type 2.
Conclusions. 1. GERD is manifested by esophageal clinical features in 66.7 % of the patients with diabetes mellitus type 2, and in 33.3 % of patients – by extraesophageal symptomatology. 2. Esophageal manifestations of GERD are more common in patients with diabetes mellitus type 2 with obesity, and extraesophageal manifestations – in patients with overweight.
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