DYNAMICS OF LIPID PROFILE INDICATORS IN PATIENTS WITH CHRONIC PANCREATITIS AND ATEROSCLEROSIS USING URSODEOXYCHOLIC ACID ON THE BACKGROUND OF COMPLEX THERAPY
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i1.8481Keywords:
chronic pancreatitis, atherosclerosis, ursodeoxycholic acid.Abstract
Over the past 30 years the incidence of chronic pancreatitis has more than doubled, the prevalence of the disease among adult population over the past 10 years became 3 times higher, and among adolescents – more than 4 times, worldwide.
The effects of ursodeoxycholic acid on lipidogram indices in patients with combination of chronic pancreatitis and atherosclerosis were studied and discussed in this paper.
The aim of the study – to learn the clinical efficacy and influence of ursodeoxycholic acid on the dynamics of lipidogram indices on the background of complex therapy in patients with chronic pancreatitis and atherosclerosis.
Material and Methods. 124 patients with chronic pancreatitis and atherosclerosis were involved in the study. The diagnosis of chronic pancreatitis was based on complaints, anamnesis, laboratory and instrumental (ultrasound of the abdomen, coprogram) findings. Dyslipidemic disorders were detected by analyzing lipid metabolism indices.
The patients were divided into two groups: the first group (65 patients), besides dietary nutrition, substitution therapy with enzymes of software, detoxification therapy, anesthetics and proton pump inhibitors, additionally received the preparation of ursodeoxycholic acid. The second group consisted of 59 patients who received similar therapy without ursodeoxycholic acid.
Results and Discussion. All patients had complains of pain in the left upper quadrant of epigastria, which was intensified after eating fatty or fried food. The dyspeptic syndrome, such as nausea, vomiting, heartburn, bloating, alternating diarrhea and constipation were observed in patients with chronic pancreatitis.
The dynamics of clinical manifestations of all 124 patients were positively influenced by treatment, but in the first group these changes were reliable, and the clinical effect occurred earlier, after 2–3 weeks of treatment.
Also, changes in lipidogram were observed. After 1 group patients treatment there was decrease in the total cholesterol from 8.17 ± 1.15 mmol/l to 6.45 ± 0.81 mmol/l; triglycerides from 3.1 ± 0.22 mmol/l to 1.9 ± 0.43 mmol/l; low density lipoproteins from 4.3 ± 0.91mmol/l to 2.6 ± 0.71 mmol/l; very low density lipoproteins from 2.2 ± 0.77 mmol/l to 1.3 ±
0.23 mmol/l; the coefficient of atherogeny from 4.85 ± 0.57 to 2.93 ± 0.38, respectively.
Conclusions. 1. Ursodeoxycholic acid is effective and safe in the complex treatment of patients with combination of chronic pancreatitis and atherosclerosis. It leads to the reduction of pain, dyspeptic syndrome, and external-secretion insufficiency syndrome. 2. The purpose of the ursodeoxycholic acid in dose of 15 mg/kg body weight for 3 months is its effects on lipidogram in these patients.
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