METABOLIC EFFECTS OF CORVITIN AND TIVORTIN IN PATIENTS WITH ESSENTIAL HYPERTENSION ASSOCIATED WITH STABLE ISCHEMIC HEART DISEASE AND TYPE 2 DIABETES MELLITUS
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i1.8472Keywords:
essential hypertension, ischemic heart disease, diabetes mellitus, metabolic indices, corvitin, tivortin.Abstract
Correction of metabolic factors of cardiovascular risk is especially important in the treatment of essential hypertension (EH), stable ischemic heart disease (SIHD) and type 2 diabetes mellitus (DM).
The aim of the study – to investigate the efficacy of treatment of patients suffering from EH associated with SIHD and type 2 DM by means of the action of Quercetin (Corvitin), 5-lipoxygenase inhibitor, and arginine hydrochloride (Tivortin), NO donator, on the intensity of lipid peroxide oxidation (LPO) and endothelial dysfunction.
Material and Methods. The study involved 65 patients suffering from EH II stage associated with SIHD and type 2 diabetes mellitus. They were randomized into two groups. Group I included 30 patients administered to common basic therapy. In addition to basic therapy the patients of group II (35 individuals) during the first six days were given infusions with Corvitin (0,5 g), followed by another six days – with Tivortin per 100 ml i/v with further changing to out-patient Tivortin intake orally in the dose of 10 ml (2 measuring spoons) twice a day during two weeks.
Results. Administration of Corvitin and Tivortin against the ground of basic therapy resulted in reliable decrease of plasma glucose concentration, immunoreactive insulin, НОМА-ИR index, malonic aldehyde (МА) of plasma and erythrocytes. From the side of antioxidant protection a reliable increase of reduced glutathione content, increased activity of glutathione peroxidase, and catalase were found. A reliable 27.3 % increase of the content of final nitrogen monoxide metabolites, 27 % increase of vascular endothelial growth factor – A (VEGF-А) were determined. In the control group I the dynamics of the examined metabolic indices in the process of treatment appeared to be inconsiderable.
References
Маslyayevа, L.V., Koval', S.N. (2006). K probleme sochetaniy arterial'noy gipertenzii s ishemicheskoy bolezn'yu serdtsa i serdechnoy nedostatochnost'yu: vse li izucheno? Chast' Í. Arterial'naya gipertenziya i ishemicheskaya bolezn' serdtsa [On the issue of association of arterial hypertension with ischemic heart disease and heart failure: is everything investigated? Part I. Arterial hypertension and ischemic heart disease]. Ukr. terapevt. zh. – Ukrainian therapist, 3, 76-83 [in Russian].
Bilovol, O.M., Shalimova, A.S., Kochueva, M.M. (2014). Komorbidnistʹ hipertonichnoyi khvoroby ta tsukrovoho diabetu 2 typu – aktualʹna problema suchasnoyi medytsyny [Comorbidity of essential hypertension and type 2 diabetes mellitus – a topical issue of modern medicine]. Ukr. terapevt. zh. – Ukrainian therapist, 1, 11-17 [in Ukrainian].
Sirenko, Yu.M., Rekovetsʹ, O.L., Savytsʹkyy, S.Yu. et al. (2010). Metabolichnyy syndrom u patsiyentiv z arterialʹnoyu hipertenziyeyu ta metabolichni efekty riznykh antyhipertenzyvnykh preparativ [Metabolic syndrome in patients with arterial hypertension and metabolic effects of different antihypertensive drugs]. Arteryal. hypertenzyya. – Arterial hypertension, 4 (12), Retrieved from: http:// www.mif-ua.com/archive/article/13618 (24.01.2013) [in Ukrainian].
Berkalo, L.V., Bobovych, O.V., Bobrova, N.O. et al. (2003). Metody klinichnykh ta eksperymentalʹnykh doslidzhenʹ v medytsyni [Methods of clinical and experimental studies in medicine]. Kaydasheva, I.P. (Ed.), Poltava: Polimet [in Ukrainian].
Ilercil, A., Devereux, R.B., Roman, M.R. et al. (2002). Associations of insulin levels with left ventricular structure and function in American Indians. Diabetes., 51 (5), 1543-1547.
Moshage, H., Kok, В., Huzenga, R. et al. (1995). Nitrite and nitrate determination in plasma: а critical evaluation. Clin. Chem., 41, 892-896.
Bobrov, V.A., Firsova, I.G. (2010). Metabolizm oksida azota i endotelial'naya disfunktsiya u bol'nykh s essentsial'noy gipertenziyey c priznakami remodelirovaniya levogo zheludochka [Nitrogen oxide metabolism and endothelial dysfunction in patients with essential hypertension with the signs of left ventricle remodeling]. Ukr. kardíol. zh. – Ukrainian cardiology, 3, 58-63 [in Russian].
Reznikov, O.H., Polumbryk, O.M., Balʹon, Ya.H. et al. (2014). Pro- ta antyoksydantna systemy i patolohichni protsesy v orhanizmi lyudyny [Pro- and antioxidant systems and pathological processes in the human organisms]. Visn. NAN Ukrayiny. – Herald of National Academy of Sciences of Ukraine, 10, 17-29 [in Ukrainian].
Kirichek, L.T., Shcherban', N.G. (2012). Metabolitnyye i metabolitotropnyye preparaty v sisteme stressprotektsii [Metabolic and metabolitotropic drugs in stress-protection system]. Mezhdunarod. med. zhurn. – International Medical Journal, 2, 103-108 [in Russian].
Nebiyeridze, D.V. (2006). Disfunktsii endoteliya i yeyo korrektsii pri arterial'noy gipertonii [Endothelial dysfunction and its correction in case of arterial hypertension]. Rus. med. zh. – Russian Medical Journal, 2, 127-131 [in Russian].
Tiritilli, A. (1998). Nitric oxide (NO), vascular protection factor. Biology, physiological role and biochemistry of NO. Presse Med., 27 (21), 1061–1064.
Malaya, L.T., Korzh, A.N., Balkovaya, L.B. (2000). Endotelial'naya disfunktsiya pri patologii serdechno-sosudistoy sistemy [Endothelial dysfunction with pathology of the cardio-vascular system]. Khar'kov: Forsing [in Russian].
Kawai, Y., Nishikawa, T., Shiba, T. et al. (2008). Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries. J. Biol. Chem., 283, 9424–9434.
Zharinova, V.Yu., Parasyuk, Ye.I., Samots', I.A. et al. (2016). Vozmozhnosti povysheniya effektivnosti antigipertenzivnoy terapii: rol' donatorov oksida azota [Possibilities to increase efficacy of anti-hypertensive therapy: the role of nitrogen oxide donators]. Zdorov’ya Ukraí̈ni. – Health of Ukraine, 1 (44), 45-46 [in Russian].
