THE INDICES OF BONE METABOLISM IN RATS WITH PERIODONTITIS ON THE BACKGROUND OF HYPER- AND HYPOTHYROIDISM
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i4.8379Keywords:
periodontitis, thyroid hormones, bone metabolism.Abstract
In Ukraine over the past five years, the number of patients with thyroid dysfunction increased five-fold. Changes in the activity of the thyroid gland inevitably affect the various systems of the body, including the functions and morphology of the organs and tissues of the oral cavity.
The aim of the study was to learn the indicators of bone metabolism in rats with periodontitis without concomitant pathology and on the background of hyper- and hypothyroidism.
Materials and Methods. The experiments were carried out on 48 outbred mature male white male rats, which were divided into four groups: the control group, the group with periodontitis, the group with periodontitis combined with hyperthyroidism, the group with periodontitis combined with hypothyroidism.
Results. Experimental periodontitis is accompanied by impaired metabolism of bone tissue due to an increase in both the processes of resorption and bone formation processes. Periodontitis with hyperthyroidism is characterized by more pronounced disturbances in bone metabolism due to a simultaneous increase in the processes of resorption and bone formation. Periodontitis on the background of hypothyroidism is accompanied by inhibition of bone resorption processes and less pronounced bone formation.
References
Bilookyi, V.V., Tkachuk, N.P., Sheremet, M.I., Hyrla, Ia.V. (2014). Analiz operatyvnykh vtruchan pry patolohii shchy- topodibnoi zalozy v Chernivetskii oblasti [Analysis of sur- gical interventions in pathology of thyroid gland in Cher- nivtsi region]. Bukovynskyi medychnyi visnyk – Bukovyna Medical Journal, 18, 3 (71), 172-174 [in Ukrainian].
Babak, O.Ia., & Telnova, S.M. (2015). Vplyv tyreoidnoi dysfunktsii na perebih arterialnoi hipertenzii u khvorykh na nealkoholnu zhyrovu khvorobu pechinky [Influence of thyroid dysfunction on the course of arterial hypertension in patients with nonalcoholic fatty liver disease]. Suchasna hastroenterolohiia – Modern Gastroenterology, 2 (82), 97- 102 [in Ukrainian].
Sutaеva, T.R., Minkailova, S.R., Shamov, I.M., & Oma- rov, O.G. (2012). Khronicheskiy generalizovannyy parodon- tit u bolnykh endemicheskim zobom [Chronic generalized periodontitis in patients with endemic goiter]. Vestnik novykh meditsinskkh tekhnologiy – Journal of New Medical Technologies, ХIХ, 3, 46-47 [in Russian].
Denga, O.V., & Kolesnik, K.A. (2012). Rol tireoidnykh gormonov v integralnoy regulyatsii kostnogo metaboliz- ma v norme i pri gipotireoze [The role of thyroid hormones in the integrated regulation of bone metabolism in normal and hypothyroidism]. Tavricheskiy mediko-biologicheskiy vestnik – Tavrichesky Medico-biological Journal, 15, 1 (57),
-337 [in Russian].
Nicholls, J., Brassil, M., Williams, G., & Bassett, J. (2012). The skeletal consequences ofthyrotoxicosis. J. En- docrinol., 213, 209-211.
Gorka, J., Taylor-Gjevre, R., & Arnason, T. (2013). Metabolic and clinical consequences of hyperthyroidism on bone density. Int. J. Endocrinol., 638727.
Basset, J., & Williams, G. (2009). The skeletal phe- notypes of TRα and TRβ mutant mice. J. Mol. Endocrinol., 42, 269-282.
Tuchendler, D., & Bolanowski, М. (2014). The influ- ence of thyroid dysfunction on bone metabolism. Thyroid Research, 7, 12.
Kalajzic, Z., Peluso, E.B., Utreja, A., Dyment, N., Ni- hara, J., Xu, M. et al. (2014). Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement. Angle Orthod., 84, 297-303.
Cardoso, L.F., Maciel, L.M.Z., & de Paula F.J.A. (2014). The multiple effects of thyroid disorders on bone and mineral metabolism. Arq. Bras. Endocrinol. Metab., 58/5, 452-463.
Piksin, I.N., Davyidkin, V.I. Moskovchenko, A.S., Vilkov, A.V. & Kechaykin, A.N. (2016). Sostoyanie kostnogo metabolizma pri zabolevaniyakh shchitovidnoy zhelezy [The state of bone metabolism in diseases of the thyroid gland]. Meditsinskiy almanakh – Medical Almanac, 4 (44), 154-157 [in Russian].
Dolidze, N.M., Kezeli, D.D., & Kilasoniya, L.O. (2007). Changes in intra- and extracellular Ca2+ concentra- tion and prostaglandin E2 synthesis in osteoblasts of the femoral bone in experimental hyper- and hypothyroidism. Bull. Exp. Biol. Med., 144, 17-20.
Tsai, J., Janson, A., Bucht, E., Kindmark, H., Mar- cus, C., Stark, A. et al. (2004). Weak evidence of thyrotro- pin receptors in primary cultures of human osteoblast-like cells. Calcif. Tissue Int., 74, 486-491.
Moyseeva, E.H. (2008). Metabolicheskiy gomeo- staz i imunnaya reaktivnost organizma v dinamike vos- paleniya v tkanyakh parodonta [Metabolic homeostasis and immune reactivity of the organism in the dynamics of inflammation in periodontal tissues]. Extended abstract of Doctorʼs thesis. Moscow [in Russian].
Ratushnenko, V.O. (2010). Funktsionalna rol tiol-dy- sulfidnoi systemy pry eksperymentalnomu hipo- i hiper- tyreozi [Functional role of thiol-disulphide system in experi- mental hypo- and hyperthyroidism]. Odeskyi medychnyi zhur- nal – Odesa Medical Journal, 2 (118), 17-20 [in Ukrainian].
European convention for the protection of verte- brate animals used for experimental and other scientific purposes. (1986). Council of Europe. Strasbourg, 123, 52.
Avdieiev, O.V. (2013). Stupin aktyvnosti fosfataz pry eksperymentalnomu parodontyti ta za yoho korektsii [Stupin activity of phosphatases during experimental pa- rodontitis and after correction]. Klinichna stomatolohiia – Clinical Stomatology, 3-4, 13-17 [in Ukrainian].
Levitskiy, A.P., Makarenko, O.A., & Denga, O.V. (2005). Eksperimentalnyye metody issledovaniya stimulya- torov osteogeneza [Experimental methods of research of stimulants of osteogenesis]. Kyiv: GFTs [in Russian].
Becerik, S., Afacan, B., & Oztürk, V.Ö. (2011). Gin- gival crevicular fluid calprotectin, osteocalcin and cross- linked N-terminal telopeptid levels in health and different periodontal diseases. Disease Markers, 31, 343-352.
Nikolaeva, A.V., & Makarenko, O.A. (2016). Izuche- nie stepeni destruktivnykh izmeneniy v tkanyah parodonta pri modelirovanii parodontita u belykh krys – samok razli- chnykh vozrastnykh periodov [The study of the degree of destructive changes in periodontal tissues during the modeling of periodontitis in white rats – females of diffe- rent age periods]. Klinichna ta eksperimentalna patologiia – Clinical and Experimental Pathology, XV, 4 (58), 74-78 [in Russian].
Drok, V.O. (2015). Vyznachennia pokaznykiv me- tabolizmu kistkovoi tkanyny u patsiientiv z zuboshche- lepnymy anomaliiamy ta osteopenichnym syndromom [Determination of bone metabolism in patients with den- tal anomalies and osteopenic syndrome]. Visnyk problem biolohii i medytsyny – Journal of Biology and Medicine, 2, 2 (119), 79-82 [in Ukrainian].
Galkina, O.P. (2013). Uroven markerov kostnogo metabolizma u podrostkov s generalizovannym parodon- titom, na fone deformatsiy pozvonochnika [The level of markers of bone metabolism in adolescents with genera- lized periodontitis, against the backdrop of deformities of the spine]. Visnyk stomatolohii – Journal of Dentistry, 3, 30-33 [in Russian].
Melnyk, N.S., & Melnyk, A.S. Markery remodeliu- vannia kistkovoi tkanyny u khvorykh na heneralizovanyi parodontyt iz suputnim hipo- i hipertyreozom [Markers of bone remodeling in patients with generalized periodon- titis with concomitant hypo- and hyperthyroidism]. TEM- PUS. dspace.zsmu.edu.ua. Retrieved from: http://dspace. zsmu.edu.ua/bitstream/123456789/3842/1/15_lyst_TEMP US_%D0%97%D0%94%D0%9C%D0%A3_109-110.pdf [in Ukrainian].
Stepan, J., Presi, J., Broulik, & P., Pacovsky, V. (1987). Serum osteocalcin levels and bone alkaline phosphatase isoenzyme after oophorectomy and in primary hyperthy- roidism. J. Clin. Endocrinol. Metab., 64, 1079-1082.
Kunimatsu, К., Mataki, S., Tanaka, Н., Mine, N., Ki- yoki, М., Hosoda, К. et al. (1993). A cross-sectional study on osteocalcin levels in gingival crevicular fluid from perio- dontal patients. J. Periodontol., 64, 865-869.
Lee, A.J., Walsh, T.F., Hodges S.J., Rawlinson, А. (1999). Gingival crevicular fluid osteocalcin in adult perio- dontitis. J. Clin. Periodontol, 26, 252-256.
Wilson, A.N., Schmid, M.J., Marx, D.B., & Rein- hardt, R.A. (2003). Bone turnover markers in serum and pe- riodontal microenvironments. J. Periodont. Res., 38, 355-361.
Nakashima, К., Roehrich, N., & Cimasoni, G. (1994). Osteocalcin, prostaglandin E2 and alkaline phosphatase in gingival crevicular fluid: Their relations to periodontal sta- tus. J. Clin. Periodontol., 21, 327-333.
