DYNAMICS OF INDICATORS OF ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN PREGNANT WOMEN WITH PLACENTAL DYSFUNCTION UNDER THE INFLUENCE OF COMPLEX THERAPY
DOI:
https://doi.org/10.11603/1811-2471.2017.v1.i3.8173Keywords:
pregnant, placenta dysfunction, malodialdeleg, drainage conjugates, superoxide dismutase, vitamin A, vitamin E, catalase.Abstract
The aim is to study the effect of complex treatment of placental dysfunction in pregnant women on changes in lipid peroxidation and antioxidant system.
Materials and methods. A comparative clinical and statistical analysis of lipid peroxidation and antioxidant system status has been carried out. Depending on the method of treatment, pregnant women were divided into two groups: 1 group-30 pregnant women received standard therapy, 11 groups - 30 pregnant women received complex therapy. The control group consisted of 30 women with a physiological course of pregnancy. The data was statistically processed using Microsoft Exel 2013 programs using the Chi-square test (χ2), Student's criterion (t), and the reliability of the differences between metrics (p).
Results and Discutions. The analysis of end products of lipid peroxidation oxidation (malonic dialdehyde, diene conjugates) and antioxidant system (vitamin A, vitamin E, superoxide dismutase, catalase) in groups depending on the method of treatment of placental dysfunction and in comparison with the control group. The comparative characterization of the level of end products of the LP indicated a significant decrease in the level of MDA and DC in Group II compared to the I group of pregnant women. A significant increase in the level of vitamin A in the second group compared to the I group was found to be 1.14 times, (p<0.05). Increased concentration of vitamin E in the second group of patients was 1.25 times compared with similar data in Group I, which did not receive the proposed therapy, which is explained by its high initial level. The proven ability of L-arginine and L-carnitine to be stimulated as enzymatic, yes and non-enzymatic chains of AOS.
Conclusions 1. One of the factors of the pathogenesis of placental dysfunction deficiency of antioxidant defense in pregnant women can be considered, which leads to an increase in the level of lipid peroxidation in blood and tissues Imbalance in the system of lipid peroxidation and antioxidant defense system leads to pathological processes in the fetoplacental complex.
2. The purpose of complex therapy with the inclusion of L-carnitine and L-arginine promotes the normalization of indicators of lipid peroxidation and antioxidant protection.
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