EXPERIENCE OF MELDONIUM IN COMBINED THERAPY OF STABLE ANGINA AND GASTROESOPHAGEAL REFLUX DISEASE
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i2.7732Keywords:
stable angina, gastroesophageal reflux disease, meldonium, 24-hour pH-metry, heartburn, odynofahiya.Abstract
Goal. To learn the meldonium (VAZONAT) effect оn the course of gastroesophageal reflux disease, GERD clinic, indicators endoscopy of the esophagus and its pH monitoring with comorbid stable angina.
Material and methods. The study included 63 patients with stable angina pectoris I-II FC with comorbid endoscopically positive GERD (A, B, C) aged 48 to 79 years. At baseline and after 30 days of treatment all patients were conducted (complaint questionnaire GSRS (Gastrointestinal Symptom Rating Scale)) and instrumental (esophagogastroduodenofibroskopy and 24-hour pH-measuring lower third of the esophagus) in order to identify the state of the esophageal mucosa, the frequency of occurrence, an amount, length and type (acid, alkaline) of gastroesophageal reflux. All patients involved in the study were divided into two groups: 1st (n = 31) took the basic therapy for the treatment of stable angina (nitrates, beta-blockers, statins, clopidogrel) and GERD (proton pump inhibitors, prokinetic , antacid) in medium therapeutic doses, 2nd group (n = 32) received the same basic therapy, except for nitrates, and, in addition, meldonium (Vazonat) 500 mg 2 times a day for 30 days.
Results. Analysis of the results showed that patients in 2 group which had Vazonat to base treatment leads to a reduction of severity of gastrointestinal symptoms, restoring the clearance of the esophagus with a significant decrease of occurrence, quantity per day, duration of acid gastroesophageal reflux, compared with those patients that received only basic therapy treatment of stable angina and GERD, where the clinical symptoms of GERD contrary strengthened.
Conclusions. In patients with stable angina pectoris and gastroesophageal reflux disease was found increased frequency of occurrence, quantity per day, duration of acid gastroesophageal reflux, changes of esophageal clearance.
Additional assignment of meldonium (Vazonat) with the basic treatment in patients with stable angina pectoris and gastroesophageal reflux disease gave opportunity to eliminate clinical symptoms, significantly reduce the frequency, duration and number of episodes of acid gastroesophageal reflux, which helped the full healing of reflux esophagitis.
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