THE FREQUENCY OF HELICOBACTER PYLORI IN PATIENTS WITH COMBINATION OF THE DIABETES MELLITUS 2 TYPE AND CHRONIC GASTRITIS
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i2.7653Keywords:
type 2 diabetes mellitus, chronic gastritis, helicobacter pylori.Abstract
SUMMARY. Helicobacter pylori (HP) is one of the most common bacterial infections worldwide, nearly half of humanity is infected. This disease is equally common in patients with diabetes mellitus (DM).
The aim – to identify the prevalence of HP infection in patients with type II diabetes (type II diabetes) and chronic gastritis (CG).
Materials and Methods. On the basis of Endocrinology and Gastroenterology Departments of Transcarpathian Regional Hospital by A. Novak we examined 95 patients aged 35 to 65 years (average age amounted to 51.2±3.4). The 65 surveyed revealed type II diabetes and hepatitis, which formed a group and patients. This study was conducted with the participation of 37 (57.0 %) women and 28 (43.0 %) men. For comparison, the second group was formed, which included 30 patients on hCG (without DC type II). In the second group of men was 18 (60.0 %), women – 12 (40.0 %). The average age of people second group was 44.6±6.8 years. In the control group included 20 healthy individuals (men was 12 (60.0 %) women – 8 (40.0 %). The average age amounted to 41.5±4.2 years.
Conclusions. 1. Prevalence of HP infection in patients with diabetes type II and CG is lower than among those with chronic gastritis (without diabetes type II), namely 52.0 % and 77.0 % respectively.
2. In patients with diabetes mellitus type II with the CG HP infection is higher in the age group 46 to 55 years is 67 %, which may indicate infection with HP at the background of type II diabetes.
3. A direct correlation between HP infection and impaired glucose tolerance in patients with diabetes type II and hCG (between HP infection and the level of HbA1c (r=0.85, p<0.01) and fasting blood glucose levels (r=0.54, p<0.05) was determined.
References
Jeffery, P.L., McGuckin, M.A., Linden, S.K. (2011). Endocrine impact of Helicobacter pylori: focus on ghrelin and ghrelin o-acyltransferase. World J Gastroenterol., 10, 1249-1260.
Devrajani, B., Shah, S.Z., Soomro, A., Devrajani, T. (2010). Type 2 diabetes mellitus: A risk factor for Helicobacter pylori infection: A hospital based case-control study. International journal of diabetes in developing countries, 1, 22.
He, C., Yang, Z., Lu, N.-H. (2014). Helicobacter pylori infection and diabetes: is it a myth or fact. World J Gastroenterol., 16, 4607-4617.
Roper, J., Francois, F., Shue, P.L. et al. (2008). Leptin and ghrelin in relation to Helicobacter pylori status in adult males. The Journal of Clinical Endocrinology & Metabolism, 6, 2350-2357.
So, W.-Y., Tong, P.C., Ko, G.T. et al. (2009). Low plasma adiponectin level, white blood cell count and Helicobacter pylori titre independently predict abnormal pancreatic β-cell function. Diabetes research and clinical practice, 2, 89-95.
Ibrahim, A., Zaher, T., Ghonemy, T.A. et al. (2010). Impact of cytotoxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes. Saudi Journal of Kidney Diseases and Transplantation, 4, 694.
Shin, D.W., Kwon, H.T., Kang, J.M. et al. (2012). Association between metabolic syndrome and Helicobacter pylori infection diagnosed by histologic status and serological status. Journal of clinical gastroenterology, 10, 840-845.
Rahman, A., Cope, M.B., Sarker, S.A. et al. (2009). Helicobacter pylori infection and inflammation implications for pathophysiology of diabetes mellitus and coronary heart disease. J life Sci., 1, 45-50.
Mahmoud, P., Vafaeimanesh, J., Bagherzadeh, M., Heidari, A., Motii, F. (2014). Diabetic patients infected with helicobacter pylori have a higher Insulin Resistance Degree. Caspian J Intern Med., 3, 137-142.
SERGHEI, C., EMILIA, T., NATALIA, F. (2016). Helicobacter pylori and type 2 diabetes mellitus: searching for the links. Russian Open Medical Journal, 2.
