COGNITIVE DYSFUNCTION AT EXPERIMENTAL TRAUMATIC BRAIN INJURY
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i1.7640Keywords:
traumatic brain injury, cognitive dysfunction.Abstract
The traumatic damage of brain is actual medical and socio-economic problem. Cognitive disorders are important aspects of craniocerebral brain injury in development of complications and disabilities.
The aim of the study was to define the features of cognitive violations at experimental traumatic brain injury (TBI).
Experimental TBI was modeling on 65 white rats-males by the V.M. Elskyi & S.V. Ziablitsev method (2005). The tests «opened field», «mink reflex» and experiment «eight-sleeve labyrinth» were used for cognitive disorders. Oppression of cognitive functions was observed directly after TBI and cognitive functions were renewal during a month.
However, indexes of orientative-trying reaction, mink reflex and «eight-sleeve labyrinth» experiment in experimental group did not attain to the levels of control group after the month.
Conclusions. Cognitive dysfunctions were observed in the nearest TBI period and after long date. Absence of complete renewal of cognitive functions testified about necessity target pharmacological facilities.
References
Elskiy, V.N., & Ziablitsev, S.V. (2008). Modelirovanie cherepno-mozgovoi travmy [Design of brain injury]. Donetsk: Novyi mir. [in Russian].
Zakharov, V.V., Drozdova, E.A. (2013). Kognitivnye narusheniya u bolnykh s cherepno-mozgovoy travmoy [Cognitive disorders in patients with cranio-cerebral injury]. Nevrologiya, neyropsihiatriya, psikhosomatika – Neurology, Neuropsychiatry, Psychosmatics, 4, 88-93 [in Russian].
Zyablitsev, S.V., & Yuzkiv, Ya. S. (2016). Mekhanizmy zapalnykh ta autoimunnykh reaktsiy pry cherepno-mozkoviy travmi [Mechanisms of inflammatory and autoimmune reactions when cranio-cerebral injury]. Patolohiia – Pathology, 1 (36), 49-53. [in Ukrainian].
Shkolnyk, V.M., Fesenko, H.D., Holyk, V.A., Pohoryelova, S.A., Pashkovskyi, V.I., & Huk A.P (2015). Kohnityvni rozlady u viddalenomu periodi cherepno-mozkovoi travmy yak prychyna obmezhennia zhyttiediialnosti poterpilykh [Cognitive disorders in remote period of cranio-cerebral injury as a reason of limited activity of victims]. Ukrainskyi neuirokhirurhichnyi zhurnal – Ukrainian Neurosurgical Journal, 2, 5-10. [in Ukrainian].
Cognitive-communication rehabilitation for combat-related mild traumatic brain injury (2012). J. Rehabil. Res. Dev., 49(7), xi-xxxii. http://www.rehab.research.va.gov/jour/2012/497/pagexi.html
Draper K., & Ponsford, J. (2008). Cognitive functioning ten years following traumatic brain injury and rehabilitation. Neuropsychology, 22 (5), 618-25. doi: 10.1037/0894-4105.22.5.618.
Helmick, K. (2010). Cognitive rehabilitation for military personnel with mild traumatic brain injury and chronic post-concussional disorder: Results of April 2009 consensus conference. Neurorehabilitation, 26 (3), 239-255. doi: 10.3233/NRE-2010-0560.
Rabinowitz, A.R., & Levin, H.S. (2014). Cognitive sequelae of traumatic brain injury. Psychiatr. Clin. North Am., 37 (1), 1-11. doi: 10.1016/j.psc.2013.11.004.
Tsaousides, T. & Gordon, W.A. (2009). Cognitive rehabilitation following traumatic brain injury: assessment to treatment. Mt. Sinai J. Med., 76 (2),173-181. doi: 10.1002/msj.20099.
