THE ROLE OF CERTAIN REGULATORY CYTOKINES IN THE IMMUNOPATHOGENESIS OF EXTRINSIC ALLERGIC ALVEOLITIS
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i1.7567Keywords:
extrinsic allergic alveolitis, cytokines, immunopathogenesis.Abstract
The article adduces the results of the study serum concentration cytokines IL-8 and IL-12, involved in the regulation of the immune response in patients with extrinsic allergic alveolitis. The data obtained by us showed differently directed changes in the production of cytokines, depending on the stages of the disease. So, EAA during the acute course is accompanied by the most pronounced changes from the proinflammatory cytokine IL-8, providing the active movement of various types of immune cells in the focus of inflammation, and the period of subacute and chronic allergic inflammation in patients with EAA is accompanied by pronounced changes in the production of IL-12 cytokine regulating the cellular immune response.
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