XENOBIOTICS INFLUENCE IN THE AIR ON THE COURSE OF ANGIOPATHY IN RATS TO MODEL SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASES
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i1.7335Keywords:
systemic autoimmune rheumatic disease, experiment, vessels, air, xenobiotics.Abstract
Systemic autoimmune rheumatic diseases (SARD) associated with adverse environmental factors that determine the rate of disease progression and survival of patients. The prevalence of these diseases increases in the regions
with air pollution.
The aim of the study – to evaluate the effect of xenobiotics in the air on the character of morphological changes in the lung blood vessels, heart and kidneys in animal with SARD models.
Materials and Methods. The experiment was conducted on outbred rats, which were divided into three groups: the first – rats with the SARD model were undergone by five hours in unfavorable atmospheric environment daily (ammonia + benzene + formalin), the second –was composed by the animal with the disease model, but were kept in normal environmental conditions, and the third - includes intact rats, which were placed in an environment with a high content of xenobiotics in the air, as well as representatives
of the first group. Histological sections of the heart tissue, lung and kidney were stained with hematoxylin-eosin, alcian blue and Van Gieson, becoming the PAS-
reaction.
Results. Changes in the lungs, heart and kidneys are found in all animals with an experimental SARD respectively 47 %, 47 % and 40 % of cases of intact rats in a hostile environment with xenobiotics air pollution. The negative environmental situation increased the frequency of morphological signs of the disease, as the proliferation of endothelial vessels of the heart by 68 % and renal arterioles by 52 %, in addition, there was a direct correlation the degree of angiopathy in individual organs, which depended from the nature of the pathological process simulation and proved the fact of atmospheric pollution as human disease risk factor. Directly with SARD model was associated the impact of pulmonary vessels sclerosis on the development of bronchosklerosis, perivascular infiltration of the heart muscle, whereas xenobiotics air pollution determined the dependence of the degree of cellular infiltration of alveolar septa by perivascular pulmonary infiltration, the development of hypertrophy of cardiomyocytes from the proliferation of endothelial vessels of the heart, kidney mesangial matrix increase from the proliferation of endothelial glomerular capillaries. Conclusion: The pollution of the atmosphere by xenobiotics should be considered as a negative factor in the development and the subsequent flow of SARD in people, and in his patogenic constructions the leading importance has angiopathy.
References
Ramos-Casals, M., Brito-Zerón, P., Kostov, B., Sisó-Almirall, A., Bosch, X., & Buss, D. (2015). Google-driven search for big data in autoimmune geoepidemiology: analysis of 394,827 patients with systemic autoimmune diseases. Autoimmun. Rev., 14 (8), 670-679. doi: 10.1016/j.autrev.2015.03.008.
Heijnen, T., Wilmer, A., Blockmans, D., & Henckaerts, L. (2016). Outcome of patients with systemic diseases admitted to the medical intensive care unit of a tertiary referral hospital: a single-centre retrospective study. Scand. J. Rheumatol. 45 (2), 146-150.
Dey-Rao, R., & Sinha, A.A. (2014). Genome-wide transcriptional profiling data from chronic cutaneous lupus erythematosus (CCLE) peripheral blood. Data Brief, 11 (2), 39-41. doi: 10.1016/j.dib.2014.11.006.
Hoffman, G.S., Calabrese, L.H. (2014). Vasculitis: determinants of disease patterns. Nat. Rev. Rheumatol., 10 (8), 454-62. doi: 10.1038/nrrheum.2014.89.
Elshabrawy, H.A., Chen, Z., Volin, M.V., Ravella, S., Virupannavar, S., & Shahrara, S. (2015). The pathogenic role of angiogenesis in rheumatoid arthritis. Angiogenesis, 18 (4), 433-448. doi: 10.1007/s10456-015-9477-2.
Maldonado, A., Blanzari, J. N., Asbert, P., Albiero, J.A., Gobbi, C., & Albiero, E. (2016). Medium vessel vasculitis in systemic lupus erythematosus. Rev Fac. Cien. Med. Univ. Nac. Cordoba, 73(1), 50-52.
Petrucci, I., Samoni, S., Meola, M. (2016). Clinical scenarios in chronic kidney disease: parenchymal chronic renal diseases. Contrib. Nephrol.,188, 98-107. doi:10.1159/000445472.
Marszałek, A., Skoczylas-Makowska, N., Kardymowicz, A., Manitius, J. (2010). Patient with rheumatoid arthritis and acute renal failure: a case report and review of literature. Pol. J. Pathol., 61(4), 229-233.
Iwasaki, S., Suzuki, A., Fujisawa, T., Sato, T., Shirai, S., & Kamigaki, M. (2015). Fatal cardiac small-vessel involvement in ANCA-associated vasculitis: an autopsy case report. Cardiovascular Pathology, 24 (6), 408-410. doi: 10.1016/j.carpath.2015.07.005
Synyachenko, O.V., Yermolaeva, M.V., Iegudyna, Ye.D., & Faerman, A.A. (2004). Izmeneniya respiratornoy sistemy pri eksperymentalnoy modeli autoimmunnogo zabolevaniya na fone lecheniya [Changes in the respiratory system in the experimental model of an autoimmune disease against treatment]. Ukr. revmatol. zhurn. – Ukrainian, Reumatological Journal, 18 (4), 3-6 [in Ukrainian].
Syniachenko, P.O., Ignatenko, G.A., Dyadik, E.A. (2011). Porazhenye endokarda i klapanov serdtsa pri eksperimentalnoy sistemnoy krasnoy volchanki [Endocardial and valvular heart disease in experimental systemic lupus erythematosus]. Vest. neotlozhn. vosstanov. med. – Journal of Emergency Recurrence Medicine, 12 (1), 102-105 [in Ukrainian].
Bevzenko, T.B. (2015) Morfologicheskie izmenenia pochek pri eksperymentalnom sistemnom vaskulite [Morphological changes in the kidneys with experimental systemic vasculitis]. Pochky – Kidneys, 13 (3), 33-36 [in Ukrainian].
Syniachenko, O.V. (2007) Revmaticheskie zabolevania i ekologia [Rheumatic diseases and ecology]. Ukr. revmatol. zhurn. – Ukrainian Reumatological Journal, 30 (4), 64-68 [in Ukrainian].
Mora, G.F. (2009) Systemic sclerosis: environmental factors. J. Rheumatol. 36 (11), 2383-2396.
Wei, P., Yang, Y., Guo, X., Hei, N., Lai, S., & Assassi, S. (2016). Identification of an Association of TNFAIP3 Polymorphisms With Matrix Metalloproteinase Expression in Fibroblasts in an Integrative Study of Systemic Sclerosis-Associated Genetic and Environmental Factors. Arthritis Rheumatol. 68 (3), 749-760. doi: 10.1002/art.39476.
Erica, L. Herzog, Aditi, M., Andrew, M. Tager, Feghali-Bostwick, & Carol (2014). Interstitial Lung Disease Associated With Systemic Sclerosis and Idiopathic Pulmonary Fibrosis. Arthritis Rheumatol., 66 (8), 1967-1978. doi: 10.1002/art.38702
Barnes, J., Mayes, M.D. (2012) Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers. Curr. Opin. Rheumatol., 24 (2), 165-170. doi: 10.1097/BOR.0b013e32834ff2e8.
Nikolenko, Iu.I., Syniachenko, O.V., Nikolenko, V.Iu., & Ananieva M.M. Sposib modeliuvannia systemnoho autoimunnoho zakhvoriuvannia [The process of modeling systemic autoimmunity]. Pat. UA № 6G09V 23/28 vid 30.10.98 r.
