VIOLATION OF LIPID PROFILE IN PATIENTS WITH CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i1.7218Keywords:
chronic pancreatitis, exocrine insufficiency of the pancreas, 13C-mixed triglyceride respiratory test, 13C-amylase respiratory test, lipid metabolism.Abstract
The article describes and analyzes dyslipidemic disorders in patients with chronic pancreatitis.
The aim – to identify and investigate lipid profile changes in chronic pancreatitis (CP) depending on exocrine pancreatic insufficiency.
Materials and Methods. We conducted a mixed triglyceride13C breath test (13C-MTBT) and amylase 13C-breath test (13C-ABT) for detection of exocrine pancreatic insufficiency (EPI). Changes in lipid profile, we determined for violations in lipid profile (determination of total plasma blood cholesterol (TC), triglycerides (TG), cholesterol of low density lipoprotein (LDL), atherogenic coefficient (AC)).
Results. In almost half of the patients we found the violation of lipid profile as increase LDL, VLDL, TC, TG, AC and reducing of HDL. It was proven relationship between the growth of EPI and dyslipidemic disorders in patients with CP – namely, the heavier the disease with more pronounced EPI and thus poorer prognosis. It was found that the course of CP with underlying atherosclerotic changes associated with lower total concentration 13SO2 late to study (16.3 ± 0.7) % (p <0.05) during the 13 C-ZTDT and (6.9 ± 1.2) % (p <0.05) during ADT13C, respectively.
References
Babinets, L.S., & Mihenko, L.M. (2011). Porushennia lipidnoho obminu v patohenezi hronichnoho pankreatytu, pidhody do yikh korektsii [Violation of lipid metabolism in pathogenesis of chronic pancreatitis, approaches to their correction]. Novosti meditsyny i farmatsii – News of Medicine and Pharmacy, 382, 67-69 [in Ukrainian].
Myshanych, T.V., Sozonjuk, A.V., & Arhij, E.J. (2015). Hemodynamichni zminy u khvorykh na hronichnyi pankreatyt na foni ishemichnoi khvoroby sertsia [Hemodynamic changes in patients with chronic pancreatitis on the background of ischemic heart disease]. Hastroenterolohiia – Gastroenterology, 2 (56), 42-47 [in Ukrainian].
Ferfetska, K.V., Fediv, O.I., & Sydorchuk L.P. (2016). Vplyv polimorfizmu gena apo-v (rs 17240441) na produktsiiu lipidnykh fraktsii u khvorykh na khronichnyi pankreatyt, poiednanyi z ozhyrinniam ta tsukrovym diabetom typu 2 [Influense of polymorphism apo-v gene (rs17240441) on the production of lipid fraction in patients with chronic pancreatitis, combined with obesity and diabetes mellitus type 2]. Klinichna ta eksperymentalna patolohiia – Clinical and Experimental Pathology, XV (2), 175-179 [in Ukrainian].
Joffe, B.I., Krut, L., Bank, S., Marks, I.N., & Keller, P. (2012). Serum lipid levels in diabetes secondary to chronic pancreatitis. Pancreatology, 19 (1), 87-90.
Qingqiang, Ni, Lin, Yun, Rui, Xu, & Dong, Shang. (2014). Correlation between blood lipid levels and chronic pancreatitis. Medicine, 93 (28), 1-6.
