INFLAMMATORY AND AUTOIMMUNITY MECHANISMS OF BRAIN INJURIES
DOI:
https://doi.org/10.11603/1811-2471.2016.v27.i3.6769Keywords:
brain injury, autoimmune mechanisms, S100B, pro-inflammatory cytokines.Abstract
SUMMARY. In a model experiment on white rats-males with the middling-heavy degree craniocerebral trauma it was shown that inflammatory and autoimmunity mechanisms include progressive growth of circulatory immune complexes and С-reactive protein; considerable accumulation in blood of neurospecific proteins, such as S100B, NSE and GAPF and, beginning from 7-th day, – autoimmune anti-phospholipid antibodies. It could be related to significant increase of proinflammatory cytokines, especially interleukine-1b and interleukine-6.
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