INFLAMMATORY AND AUTOIMMUNITY MECHANISMS OF BRAIN INJURIES

Authors

  • S. V. Ziablitsev O. Bohomolets National Medical University, Kyiv
  • Ya. S. Yuzkiv O. Bohomolets National Medical University, Kyiv

DOI:

https://doi.org/10.11603/1811-2471.2016.v27.i3.6769

Keywords:

brain injury, autoimmune mechanisms, S100B, pro-inflammatory cytokines.

Abstract

SUMMARY. In a model experiment on white rats-males with the middling-heavy degree craniocerebral trauma it was shown that inflammatory and autoimmunity mechanisms include progressive growth of circulatory immune complexes and С-reactive protein; considerable accumulation in blood of neurospecific proteins, such as S100B, NSE and GAPF and, beginning from 7-th day, – autoimmune anti-phospholipid antibodies. It could be related to significant increase of proinflammatory cytokines, especially interleukine-1b and interleukine-6.


 

References

Horbunov V. Y. Ymmunopatolohyya travmatycheskoy bolezny holovnoho moz·ha / V. Y. Horbunov. – Ulʹyanovsk, 1996. – S. 409–421.

Ymmunnyy status v ostrom peryode tyazheloy cherepno-moz·hovoy travmy pry razvytyy hnoyno-septycheskykh oslozhnenyy / T. Y. Borshchykova, N. N. Epyfantseva, H. S. Surzhykova [y dr.] // Obshchaya reanymatolohyya. – 2010. – № 6 (3). – S. 35–42. doi:10.15360/1813-9779-2010-3-35.

Mamytova É. M. Osobennosty ymmunnykh narushenyy v ostrom peryode cherepno-moz·hovoy travmy / É. M. Mamytova, É. S. Maynazarova, A. T. Zhusupova // Vestnyk KRSU. – 2014. – T. 14, № 4. – S. 120–123.

Ymmunolohycheskye yzmenenyya pry cherepnomoz·hovoy travme / R. KH. Ysaeva, Y. A. Antonyuk, A. V. Hrydyakyna, A. E. Evstafʹeva // Mezhdunarodnyy zhurnal prykladnykh y fundamentalʹnykh yssledovanyy. – 2014. – № 8 – S. 41–47.

Korovka S. YA. Mekhanizmy formuvannya syndromu endohennoyi intoksykatsiyi pry travmatychniy khvorobi holovnoho mozku : avtoref. dys. na zdobuttya nauk. stupenya kand. med. nauk : spets. 14.03.04 «Patolohichna fiziolohiya» / S. YA. Korovka. – Donetsʹk, 2013. – 20 s.

Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats / X. J. Huang, O. Glushakova, S. Mondello [et al.] // J. Neurotrauma. – 2015. – Vol. 32 (16). – P. 1179–1189. doi:10.1089/neu.2015.3873.

Khrapov YU. V. Rolʹ byomarkerov povrezhdenyya veshchestva holovnoho moz·ha v dyahnostyke, otsenke éffektyvnosty lechenyya y prohnozyrovanyy yskhodov tyazheloy cherepno-moz·hovoy travmy / YU. V. Khrapov, S. V. Poroyskyy // Volhohradskyy nauchno-medytsynskyy zhurnal. – 2013. – № 3. – S. 10–20.

Biloshytsʹkyy V. V. Mozhlyvosti biokhimichnykh biomarkeriv yak zasobiv prohnozuvannya perebihu cherepnomozkovoyi travmy / V. V. Biloshytsʹkyy, O. YA. Kobyletsʹkyy // Ukrayinsʹkyy neyrokhirurhichnyy zhurnal. – 2015. – № 1. – S. 4–14.

Elʹskyy V. N. Modelyrovanye cherepno-moz·hovoy travmy / V. N. Elʹskyy, S. V. Zyablytsev. – Donetsk : Yzd-vo «Novyy myr», 2008. – 140 s.

Abu Salekh Ammar Ybrakhym. Rolʹ tsytokynov v patoheneze ostroho peryoda cherepno-moz·hovoy travmy : avtoref. dys. na soyskanye uch. stepeny kand. med. nauk : spets. 14.00.13 «Nervnye bolezny» / Abu Salekh Ammar Ybrakhym. – Moskva, 2007. – 22 s.

Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice // F. Clausen, A. Hảnell, M. Björk [et al.] // Eur. J. Neurosci. – 2009. – Vol. 30 (3). – P. 385–396.

S100B expression in and effects on microglia / C. Adami, G. Sorci, E. Blasi [et al.] // Glia. – 2001. – Vol. 33. – P. 131–142.

Rolʹ apoptozu v systemnykh proyavakh tyazhkoyi travmy / A. A. Hudyma, M. R. Khara, L. S. Fira [ta in.]. – Ternopilʹ : Ukrmedknyha, 2010. – 241 s.

Neyronspetsyfycheskye belky – markery éntsefalopatyy pry tyazhëloy sochetannoy travme / E. V. Hryhorʹev, H. V. Vavyn, T. H. Hryshanova [y dr.] // Medytsyna neotlozhnykh sostoyanyy. – 2010. – № 2 (27). – S. 87–92.

Published

2016-10-10

How to Cite

Ziablitsev, S. V., & Yuzkiv, Y. S. (2016). INFLAMMATORY AND AUTOIMMUNITY MECHANISMS OF BRAIN INJURIES. Achievements of Clinical and Experimental Medicine, 27(3). https://doi.org/10.11603/1811-2471.2016.v27.i3.6769

Issue

Section

Оригінальні дослідження