DISTRIBUTION OF S-100b IN THE RAT BRAIN UNDER PITUITRIN-IZADRIN MODEL OF HEART ISCHEMIA
DOI:
https://doi.org/10.11603/1811-2471.2016.v27.i3.6766Keywords:
experimental ischemia, S-100b protein, izadrin, pituitrin.Abstract
Summary. Ischemia of the heart and brain is a damage that is caused by decreased blood flow and limit the flow of oxygen and glucose to the tissue. S-100b protein is produced mainly by astrocytes in the brain. Astrocytes are the cells of the brain that give the earliest respond to metabolic deficiency as a primary element in the blood-brain barrier between blood vessels and neurons. Focal brain ischemia induces the redistribution of calcium-binding protein S-100b and the elevation of its level in the blood. Quantitative changes of S-100b are considered as a marker of brain damage. Obtained data indicate that pituitrin-izadrin induced model of heard ischemia lead just to minor changes in metabolism of S-100b protein in the rat brain.
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