CLINICAL AND GENETIC MARKERS OF INEFFECTIVE ANTIHYPERTENSIVE TREATMENT IN HYPERTENSIVE PATIENTS
DOI:
https://doi.org/10.11603/1811-2471.2016.v26.i2.6253Abstract
SUMMARY. CYP11B2 promotor region polymorphism -344C/T (rs1799998) plays one of the key roles in volume and
electrolyte balance modulation in hypertension. Relevant pharmacogenetic research is tending to find genetic markers,
associated with ineffective high BP control, not related to drug dose, administration regimen or patient’s compliance.
The study aimed to evaluate the role of -344С/Т CYP11B2 polymorphism in combination with traditional cardiovascular
risk factors in hypertensive patients with hypertension stages II-III and variable blood pressure control. 93 hypertensive
patients aged 61.1±8.9 years were divided into groups according to BP levels: 1st group (n=38) – patients achieving goal
BP levels under antihypertensive treatment, 2nd group (n=55) – patients with BP levels ≥135/85 mm Hg, taking maximal
tolerated registered doses of antihypertensive agents. Apart from standard clinical evaluation, assessment involved
cardiovascular risk factors and -344С/Т CYP11B2 SNP genotyping. Groups were comparable by modifiable risk factors
and number of males, quality and quantity of antihypertensive agents. In the same time patients who did not achieve
proper BP control were smokers and diabetic more often than those who achieved BP goals under treatment. T-allele
carriers and T-monozygous patients demonstrated poor BP control comparing to patients with other genotype under
the same clinical conditions and treatment.
Key words : hypertension, single-nucleotide polymorphism -344 С/Т CYP11B2, antihypertensive treatment
efficacy.
References
Modulation of aldosterone levels by -344 C/T
CYP11B2 polymorphism and spironolactone use in resistant
hypertension / V. Fontana, A. De Faria, N. Barbaro [et
al.] // J. Am. Soc. Hypertens. – 2014. – № 8. – R. 146–151.
Effect of renin-angiotensin-aldosterone system
gene polymorphisms on blood pressure response to antihypertensive
treatment / X. Jiang, H. Sheng, G. Lin [et
al.] // Chin Med J. – 2007. – № 120. – R. 782–786.
Interaction of ACE and CYP11B2 genes on blood
pressure response to hydrochlorothiazide in Han Chinese
hypertensive patients / Y. Li, Y. Zhou, P. Yang [et al.] // Clin.
Exp. Hypertens. – 2011. – № 33. – R. 141–146.
Variants of the CYP11B2 gene predict response to
therapy with candesartan / J.R. Ortlepp, P. Hanrath, V. Mevissen
[et al.] // Eur. J. Pharmacol. – 2002. – № 445 (1–2). –
R. 151–152.
Aldosterone synthase (CYP11B2) -344 C/T polymorphism
is related to antihypertensive response: result
from the Swedish Irbesartan Left Ventricular Hypertrophy
Investigation versus Atenolol (SILVHIA) trial / L. Kurland,
H. Melhus, J. Karlsson [et al.] // Am. J. Hypertens. – 2002. –
Vol. 15 (5). –R. 389–393.
Clinical practice guidelines for the management of
hypertension in the community a statement by the American
Society of Hypertension and the International Society
of Hypertension / M. Weber, E. Schiffrin, W. White [et al.] //
J. Hypertens. – 2014. – № 32. – P. 3–15.
Unifikovanyy klinichnyy protokol medychnoyi do-
pomohy «Arterialʹna hipertenziya» [Elektronnyy re-
surs] / [M. K. Khobzey, V. Z. Netyazhenko, L. I. Bozhko ta in.] //
MOZ Ukrayiny. – 2012. – Rezhym dostupu do resursu: http://
www.moz.gov.ua/ua/portal/dn_20120524_384.html.
Adaptovana klinichna nastanova, zasnovana na do-
kazakh «Arterialʹna hipertenziya» [Elektronnyy resurs] /
[M. K. Khobzey, V. Z. Netyazhenko, L. I. Bozhko ta in.] // MOZ
Ukrayiny. – 2012. – Rezhym dostupu do resursu: http://
www.moz.gov.ua/ua/portal/dn_20120524_384.html.
Walsh P. S. Chelex 100 as a Medium for Simple Extraction
of DNA for PCR-Based Typing from Forensic Material
/ P. S. Walsh, D. A. Metzger, R. Higuchi. // BioTechniques.
– 2013. – № 54. – R. 134–139.
Association of the -344T/C aldosterone synthase
gene variant with essential hypertension / Z. Hlubocká,
M. Jáchymová, S. Heller [et al.] // Physiol. Res. – 2009. –
№ 58. – P. 785–792.
Cheng X. Association between aldosterone synthase
CYP11B2 polymorphism and essential hypertension
in Chinese: A meta-analysis / X. Cheng, G. Xu // Kidney
Blood Press Res. – 2009. – № 32. – P. 128–140.
