JUSTIFICATION MECHANISM OF NANO METAL OXIDES ON PATHOGENIC FLORA PURULENT WOUNDS
DOI:
https://doi.org/10.11603/1811-2471.2016.v26.i2.6249Abstract
ineffective treatment leads to search, study and implementation of new antimicrobial drugs to combat infection in
the wound. Today, there are increasing reports of high antibacterial effectiveness of nanoscale metal oxides, particularly
zinc oxide. Unfortunately, we do not fully understand the mechanism of action of zinc nano oxides bacterial cell. The aim
of our study was the action of nano zinc oxide in bacteria using quantum chemical calculations. Materials and methods.
For the calculation used a PM3 method for calculating the structural and energy parameters of the systems. Result.
As a result of quantum-chemical calculations proved antibacterial activity nano oxide zinc because the energetically
beneficial radical removal of oxygen from the surface of the nano oxides leads to a series of radical reactions to form
peroxides and subsequent destruction of bacteria.
KEY WORDS: nano oxide zinc, magnesium nano oxide, pathogenic flora, mechanism of action, quantum-chemical
calculations.
References
Horyunov S. V. Hnoynaya khyrurhyya. Atlas / S. V. Ho-
ryunov, D. V. Roashov, Y. A. Butyvshchenko. – M. : Bynom. –
– 558 s.
The epidemiology of hospitalized cases of skin
and soft tissue infection in Europe / S. Pulgar, M. Mehra,
A. Quintara [et al.] // Abstr 18th ECCMID. – Barselona,
Spain. – 2008. – P. 821.
Paliy H. K. Porivnyalʹna kharakterystyka anty-
septychnoyi efektyvnosti dekametoksynu ta furatsylinu /
H. K. Paliy, M. YE. Nechytaylo, V. P. Kovalʹchuk [et al.] //
Zdorov'ya Ukrayiny. – 2010. – № 22. – S. 56–57.
Blautyn L. A. Mestnoe medykamentoznoe leche-
nye ran. Problemy y novye vozmozhnosty ykh reshenyya /
L. A. Blautyn // Consilium medicum: khyrurhyya (prylozh). –
– № 1. – S. 9–16.
Chekman I. S. Nanonauka: istorychnyy aspekt, per-
spektyvy doslidzhenʹ / I. S. Chekman // Ukr. Med. Chaso-
pys. – 2009. – № 3 (71), T. V/VI. – S. 19–21.
Huang L. Controllable preparation of Nano-MgO
and investigation of its bactericidal properties / L. Huang //
J. Inorg Biochem. – 2005. – Vol. 99. – R. 986–993.
Consolidation of Metal Oxide Nanocrystals. Reactive
Pellets with Controllable Pore Structure That Represent
a New Family of Porous, Inorganic Materials / R. Richards,
W. Li, S. Decker [et al.] // J. Am. Chem. Soc. – 2000. –
Vol. 122. – R. 4921–4925.
Nanoscale Powders and Formulations with Biocidal
Activity Toward Spores and Vegetative Cells of Bacillus
Species, Viruses, and Toxins / O. Koper, J. Klabunde,
G. Marchin [et al.] // Current Microbiology. – 2002. –
Vol. 44. – R. 49–55.
Padmavathy N. Enhanced bioactivity of ZnO nanoparticles–
an antimicrobial study / N. Padmavathy, R. Vijayaraghavan
// Sci. Technol. Adv. Mater. – 2008. – Vol. 9. – R. 1–7.
Flexible and Microporous Chitosan Hydrogel /
Nano ZnO Composite Bandages for Wound Dressing: In
Vitro and In Vivo Evaluation / P. T. Sudheesh Kumar, Vinoth-
Kumar Lakshmanan, T. V. Anilkumar [et al.] // ACS Appl.
Mater. Interfaces. – 2012. – Vol. 4 (5). – R. 2618–2629.
Antibacterial Activity and Mechanism of Action of
Zinc Oxide Nanoparticles against Campylobacter jejuni //
Y. Xie, Y. He, P. L. Irwin [et al.] // Applied and Environmental
Microbiology. – 2011. – Vol. 4. – R. 2325–2331.
Tsynk i nanotsynk: vlastyvosti, zastosuvannya u
klinichniy praktytsi // I. S. Chekman, Z. R. Ulʹberh, A. D. Ru-
denko [ta in.] // Ukr. Med. Chasopys. – 2013. – № 2 (94),
T. III/IV. – S. 42–47.
Review on Zinc Oxide Nanoparticles: Antibacterial
Activity and Toxicity Mechanism / A. Sirelkhatim, S. Mahmud
A. Seeni [et al.] // Nano-Micro Lett. – 2015. – Vol. 7 (3). –
R. 219–242.
Brovaretsʹ O. O. Kvantovo-khimichne doslidzhennya
elementarnykh molekulyarnykh mekhanizmiv pirymidynovo-
purynovykh transversiy / O. O. Brovaretsʹ D. M. Hovo-
run // Ukr. biokhim. zhurn. – 2010. – № 5, T. 8. – S. 257–267.
Kvantovo-khimichne modelyuvannya vzayemodiyi me-
tyltretbutylovoho efiru z lipidnym sharom plazma-
tychnoyi membrany / O. P. Yavorovsʹkyy, V. V. Lobanov,
O. H. Minchenko [ta in.] // Ukrayinsʹkyy medychnyy zhurnal z
problem medytsyny pratsi. – 2015. – № 2 (43). – S. 32–40.
Stoimenov P. K. Metal oxide nanoparticles as bactericidal
agents / P. K. Stoimenov // Langmuir. – 2002. –
Vol. 18. – P. 6679–6686.
Klabunde KJ. Nanocrystals as Stoichiometric Reagents
with Unique Surface Chemistry / K. J. Klabunde,
J. Stark, O. Koper [et al.] // J. Phys. Chem. – 1996. –
Vol. 100. – R. 12142–12153.
Baruah S. Hydrothermal growth of ZnO nanostructures
/ S. Baruah, J. Dutta // Sci. Technol. Adv. Mater. –
– Vol. 10. – P. 1–18.
Solovev M. E. Kompʹyuternaya khymyya / M. E. So-
lovev, M. M. Solovev. – M. : SOLON-press, 2005. – 536 s.
Antibacterial activity of ZnO nanoparticle suspensions
on a broad spectrum of microorganisms / N. Jones,
B. Ray, K. T. Ranjit, A. C. Manna // FEMS Microbiol Lett. –
– Vol. 279 (1). – R. 71–76.
