Effect of blocking M1-cholinergic receptors in associative cortex of adult rats on autonomic regulation of heart rate during hypoxic exposure
DOI:
https://doi.org/10.11603/1811-2471.2015.v24.i4.5797Abstract
Summary. Simulation of the atmospheric hypoxia in experiments on rats allows to explore more detail the neurotransmitter substances involved in the formation of adaptation of the brain regulatory systems to hypoxic exposure. The aim of the experiment was to determine the functional consequences of blocking M1-cholinergic receptors at associative cortex in adult rats in the hypoxic environment under conditions of low atmospheric pressure. In the experiment with hypoxic infuence, the functional reorganization of cholinergic structures involvement to different mechanisms for heart rate autonomus control were observed. Incubation of adult rats with hypoxic environment under conditions of low atmospheric pressure, that was similar to natural conditions of weather type III, leads to activation of cholinergic regulation of heart rhythm.
Key words: M1-cholinergic receptors blocking, associative cortex, reduced atmospheric pressure.
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