MORPHOMETRIC ASSESSMENT OF THE FEATURES OF REMODELING ARTERIAL VESSELS OF THE THYROID HEMOMICROCIRCULATORY BED AT POSTRESECTION PORTAL HYPERTENSION
DOI:
https://doi.org/10.11603/1811-2471.2025.v.i4.15678Keywords:
thyroid gland, arterioles, precapillary arterioles, postresection portal hypertension, morphometryAbstract
SUMMARY. Vessels of the hemomicrocirculatory bed fully provide trophism of organs and systems of the body at the level of capillary-tissue relations and are the first to respond to various functional and pathological conditions. At the same time, quantitative structural changes in arterial and metabolic microvessels of the thyroid gland in conditions of prolonged postresection portal hypertension have not been studied sufficiently.
The aim – to study quantitative morphological changes in arterial vessels of the hemomicrocirculatory bed of the thyroid gland of white rats at postresection portal hypertension.
Material and methods. The arterial vessels of the hemomicrocirculatory bed of the thyroid gland were morphologically studied in 60 white male rats, which were divided into three groups. Group 1 – 15 intact animals, 2 – 30 white male rats with postresection portal hypertension, 3 – 15 animals with postresection portal hypertension complicated by multiple organ failure. The animals were euthanized by bleeding under thiopental anesthesia. Micropreparations and semi-thin sections were prepared from the thyroid gland, on which the area, lumen, intima, walls of arterioles, precapillary arterioles, arteriole indices, and precapillary arterioles were determined. Quantitative indicators were processed statistically.
Results. It was established that postresection portal hypertension was accompanied by pronounced remodeling of the arterial vessels of the hemomicrocirculatory bed of the thyroid gland. It was found that in postresection portal hypertension, the area of the lumen of arterioles decreased by 57.9 %, pre-capillary arterioles – by 46.4 %, in the conditions of combination of postresection portal hypertension with multiple organ failure, the above morphometric parameters were changed by 61.3 % and 52.2 %, respectively (p<0.001).
Conclusions. The conducted studies and the obtained results indicate that the resection of the left and right lateral lobes of the liver is complicated by postoperative portal hypertension, which leads to pronounced remodeling of the arterial vessels of the hemomicrocirculatory bed of the thyroid gland, which is characterized by thickening of their walls, narrowing of the lumen, reduction of arterial blood in the hemomicrocirculation system, hypoxia, dystrophy, necrobiosis, apoptosis of endothelial cells, thyrocytes, stromal components, foci of infiltration and proliferation of connective tissue. The established structural changes in the thyroid gland of white rats prevailed in the combination of post-resection portal hypertension with multiple organ failure.
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