QUANTITATIVE MORPHOLOGICAL ANALYSIS OF STRUCTURAL CHANGES IN THYROID VENOUS VESSELS AT THE CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION

Authors

DOI:

https://doi.org/10.11603/1811-2471.2025.v.i2.15310

Keywords:

thyroid gland, venous vessels, postresection portal hypertension

Abstract

SUMMARY. The venous bed provides venous drainage from organs and systems of the body and responds to various changes in hemodynamics, functional and pathological conditions. At the same time, the structure of the venous vessels of the thyroid gland in portal hypertension has not been studied sufficiently.

The aim – to investigate the features of structural changes in the venous vessels of the thyroid gland in postresection portal hypertension using quantitative morphological methods.

Material and Methods. Morphological and morphometric methods were used to study the venous vessels of the thyroid gland in 60 white male rats, which were divided into 3 groups. Group 1 – 15 intact animals, 2 – 30 rats with postresection portal hypertension, which was modeled by removal of the left and right lateral lobes of the liver, 3 – 15 animals with postresection portal hypertension, which developed multiorgan failure. The animals were euthanized one month after the start of the experiment. Histological preparations and ultrathin sections were prepared from the thyroid gland. The area of the vessel, its lumen and the walls of the extracapillary venules, venules, and veins of the thyroid gland were determined morphometrically. In the latter, the area of endothelial cells, their nuclei, nuclear-cytoplasmic ratios, and the relative volume of damaged endothelial cells were determined. Quantitative indicators were processed statistically.

Results. It was established that with portal hypertension, extracapillary venules and venules, veins expanded, their walls thinned, and the number of damaged endothelial cells increased. The structural reorganization of the studied vessels was more pronounced in the combination of postresection portal hypertension with multiple organ failure. The relative volume of damaged endothelial cells in the venous vessels of the thyroid gland with postresection portal hypertension increased by 9.7 times, and with the occurrence of multiple organ failure – by 15.9 times.

Conclusions. The conducted studies and the obtained results indicate that postresection portal hypertension leads to dilation of the venous vessels of the thyroid gland, thinning of their walls, pronounced venous congestion, hypoxia, dystrophy, necrobiosis of epithelial cells, endothelial cells, stromal structures, foci of infiltration and sclerosis. Structural changes of the venous bed in the thyroid gland of white rats dominate in the combination of postresection portal hypertension with multiple organ failure.

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Published

2025-06-04

How to Cite

Hnatyuk, M. S., Chernetskyy, A. A., Tatarchuk, L. V., & Stets, N. Y. (2025). QUANTITATIVE MORPHOLOGICAL ANALYSIS OF STRUCTURAL CHANGES IN THYROID VENOUS VESSELS AT THE CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION. Achievements of Clinical and Experimental Medicine, (2), 57–61. https://doi.org/10.11603/1811-2471.2025.v.i2.15310

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Original research articles