OXIDATIVE STATUS IN PATIENTS WITH UROLITHIASIS ON THE BACKGROUND OF POST-COVID SYNDROME
DOI:
https://doi.org/10.11603/1811-2471.2025.v.i2.15307Keywords:
urolithiasis, post-covid syndrome, oxidative status, uric acid, blood serum, urineAbstract
SUMMARY. The aim – to determine the components of oxidative status in the blood serum and urine of patients with urolithiasis on the background of post-covid syndrome (PCS): the content of malone dialdehyde (MDA), ceruloplasmin (CP), transferrin (Tr), the CP/Tr ratio, as well as the content of uric acid (UA).
Material and Methods. 44 patients with urolithiasis and PCS were examined. The average age of the patients was 43.6±6.1 years, 27 men, 17 women. Control group included 30 practically healthy individuals. The kidney function of the patients, according to the indicators of creatinine and urea in serum, was preserved. In all patients, the course of the disease was not accompanied by attacks of acute or exacerbation of chronic pyelonephritis. Determination of MDA, CP, Tr and UA was carried out before removal of the calculus. Urine for analysis was obtained after physiological urination. The content of MDA and UA in blood serum and urine was expressed in mmol/l, the CP content in g/l, the Tr content in conventional units. The CP /Tr ratio was also calculated.
Methods of classical statistical data processing (M±m) were used, which were performed after analyzing the correspondence of their distribution to normal.
Results. In patients with urolithiasis and PCS, there is a significant increase in blood serum and urine MDA and UA content (p<0.01–0.001), a significant increase in CP content, a significant decrease in Tr content and a significant increase in CP/Tr in blood serum (p<0.001). It was established that there was no findings of the content of CP and Tr in the urine of patients.
Conclusions. Initiation of lipid peroxidation processes (according to MDA determination data), a significant increase in UA content and a significant violation of the state of the antioxidant defense system (according to CP, Tr and CP/Tr determination data) indicates the development and presence of signs of oxidative stress in patients with urolithiasis against the background of PCS.
References
Samchuk PO, Krasiuk OY, Iskenderov RK, Metelskyi SO, Klymenko YaM, Hritsai VS. Urolithiasis: modern approaches to classification, diagnosis and treatment. Health of Man. 2023;(2):60-67. DOI: 10.30841/ 2786-7323.2.2023.286440 DOI: https://doi.org/10.30841/2786-7323.2.2023.286440
Wagner CA. Etiopathogenic factors of urolithiasis. Arch. Esp. Urol. 2021;74(1): 16-23.
Ozhogin VV. Modern methods of treatment of proximal ureterolithiasis. Health of Man. 2021;(3):95-101. DOI: 10.30841/2307-5090.3.2021.246216 DOI: https://doi.org/10.30841/2307-5090.3.2021.246216
Gambaro G, Croppi E, Bushinsky D, Cupisti A, Ticinesi A, et al. The Risk of Chronic Kidney Disease Associated with Urolithiasis and its Urological Treatments: Review. J. Urol. 2017;198:268-273. DOI: https://doi.org/10.1016/j.juro.2016.12.135
Makienko NV, Minukhin VV, Kolyada TI, Toryanyk II, Sklyar AI. The main clinical and immunological aspects of postCOVID syndrome. Annals of Mechnikov Institute. 2022;(3):21-27. DOI: 10.5281/zenodo.7070908
Nayak Unnathi, et al. Post-COVID syndrome: A literature review of complications following infection by severe acute respiratory syndrome Coronavirus-2. Journal of Datta Meghe Institute of Medical Sciences University. 2022;17(Suppl 1):S141-S150. DOI: https://doi.org/10.4103/jdmimsu.jdmimsu_335_21
Garg P, Arora U, Kumar A, Wig N. The «post-COVID» syndrome: How deep is the damage? Journal of Medical Virology. 2021;93(2):673-674. DOI: 10.1002/jmv.26465 DOI: https://doi.org/10.1002/jmv.26465
Carfi A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. Jama. 2020;324(6):603-605. DOI: 10.1001/jama.2020.12603 DOI: https://doi.org/10.1001/jama.2020.12603
Chernenko VV, Chernenko DV, Zheltovska NI, Savchuk VJ, Bondarenko YuM, Klius AL, Pilipenko YeV. Hipercrystalluria as a factor in the development of urine stone disease, diagnosis and directions of treatment. Health of Man. 2022;(4):77-84. DOI: 10.30841/2307-5090. 4.2022.274448. DOI: https://doi.org/10.30841/2307-5090.4.2022.274448
Kushwaha RS, Gupta RC, Sharma S, et al. Chronomicsof Circulating Plasma Lipid Peroxides and Antioxidant Enzymes in Renal Stone Formers. Indian J Clin Biochem. 2019;34(2):195-200. DOI: 10.1007/s12291-017-0726-6. DOI: https://doi.org/10.1007/s12291-017-0726-6
Woźniak P, Kontek B, Różański W, Olas B. The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shockwave lithotripsy. Future Med. Chem. 2018;10(23):2685-2693. DOI: 10.4155/fmc-2018-0149. DOI: https://doi.org/10.4155/fmc-2018-0149
Molodan DV. The dynamics of indicators of tumor necrosis factor alpha activity and lipid peroxidation in patients with essential hypertension associated with obesity and hyperuricemia. Immunology and Allergy: Science and Practice. 2013;(2):26-30.
Cirillo Pietro, Sautin YY, Kanellis J, et al. Systemic inflammation, metabolic syndrome and progressive renal disease. Nephrol. Dial. Transplant. 2009;(24): 1384-1387. DOI: 10.1093/ndr/gfp038 DOI: https://doi.org/10.1093/ndt/gfp038
Korol LV, Myhal LYa, Nikulina GG, Kolesnyk MO. Biochemical methods for evaluating oxidative status in patients with chronic kidney disease [Biokhimichni metody otsinky oksydatyvnoho statusu u khvorykh na khronichnu khvorobu nyrok: metod. rekomendatsiyi]. Method. Recommendations of Ministry of Health of Ukraine, Academy of Medical Sciences of Ukraine, Ukrainian Center for Scientific Medical Information and Patent Licensing Work. Kyiv: [b.v.]. 2013; 1-30. Ukrainian.
