FEATURES OF THE INFLUENCE OF GUT MICROBIOTA ON HIGHER BRAIN FUNCTIONS

Authors

DOI:

https://doi.org/10.11603/1811-2471.2025.v.i2.15274

Keywords:

gut microbiota, diet, brain function, gut-brain axis, cognitive function

Abstract

SUMMARY. The aim – to analyze modern systematic reviews and studies devoted to the influence of diet on higher brain activity through the modulation of gut microbiota.

Material and Methods. A search was conducted in the PubMed, Scopus and Web of Science databases among publications over the last 10 years (2014–2024) using the keywords: “gut microbiota”, “diet”, “brain function”, “gut-brain axis”. The review included 25 systematic reviews and experimental studies that met the criteria: the presence of an assessment of the dietary modification impact on cognitive functions through changes in the microbiota.

Results. Over the past ten years, researchers have increasingly paid attention to the role of the gut microbiota in the regulation of brain functions and behavior. Accumulating evidence suggests that disruption of the microbiota, for example due to an unbalanced diet, stress or inflammatory processes, can contribute to the development of affective disorders, including depression. Dietary habits are one of the main factors determining the composition of the microbiota throughout a person’s life. Several mechanisms of interaction between the gut and the brain have been identified, including microbial metabolites, immune responses, neural and metabolic processes. Some of these pathways can be modified by diet. In particular, a diet rich in prebiotics, probiotics and polyunsaturated fatty acids is associated with improved cognitive function and reduced anxiety levels. In this context, studies that demonstrate the possibility of modulating mental health by correcting the microbiota - through probiotics, prebiotics, dietary changes and effects on metabolic pathways - are of particular interest. In the future, such approaches may complement traditional psychiatric therapy, in particular in the treatment of depression.

Conclusions: There is a strong evidence base that suggests that diet influences brain function through the gut microbiota. Further research is needed to better understand the molecular mechanisms and identify effective dietary interventions to improve neuropsychological health.

References

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Published

2025-06-04

How to Cite

Tkachenko, S. S., Rodynskyi, O. G., & Bilei, M. V. (2025). FEATURES OF THE INFLUENCE OF GUT MICROBIOTA ON HIGHER BRAIN FUNCTIONS. Achievements of Clinical and Experimental Medicine, (2), 14–18. https://doi.org/10.11603/1811-2471.2025.v.i2.15274

Issue

Section

Literature reviews