MicroRNA AS A PERSPECTIVE OF TERAGNOSTICS IN VIRAL INFECTIOUS DISEASES
DOI:
https://doi.org/10.11603/1811-2471.2025.v.i1.15241Keywords:
theragnostic, miRNAs, biomarkers, biomolecules, viral miRNAsAbstract
SUMMARY. The significant spread of new diseases in the modern world, including those of viral origin, creates prerequisites for the development of new directions of diagnosis and treatment. A direction in medicine called theragnostics is gaining significant development. The basis of theragnostics is molecular biology and nanotechnologies, which make it possible to provide early diagnosis of pathological processes, targeted treatment, which involves spot impact on key links of the pathological process, which makes it possible to increase the effectiveness of therapy.
The aim – to justify the prospects for the use of microRNAs as potential drugs for theragnosis.
Material and Methods. Publications in scientific journals, which are analyzed by methods of evaluation of scientific novelty, comparison with publications of the same direction, correspondence of the methodology to the research topic, possibility of reproducing the experiment; correctness of graphs, tables and schemes.
Results. Scientific research in recent years has shown the versatility of microRNA. Genomes of viruses encode specific viral microRNAs (vmiR), which have pathogenetic and diagnostic significance. Separate groups of drugs with potential antiviral properties that block target genes as mimetics of microRNAs have been obtained.
Conclusions. Some human microRNAs can be used as diagnostic and prognostic biomarkers of the infectious process. The expression of miRNA has characteristic features in various infectious processes, in particular in HIV/AIDS, viral hepatitis, SARS-Covid infection, etc. Micro-RNAs of the host can have both proviral and antiviral effects.
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