MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT OF MYCOSAL PNEUMONIA IN CHILDREN AND ADOLESCENTS IN THE PRACTICE OF A FAMILY DOCTOR IN A TIME OF UNCERTAINTY
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i4.15025Keywords:
mycosis, pneumonia, diagnosis, treatment, prevention, children, adolescents, uncertaintyAbstract
SUMMARY. Mucosal pneumonias are an important medical problem, especially in conditions of impaired immune status of patients.
The aim – to summarize data on the etiology of mycosis pneumonias, risk factors for their occurrence in children and adolescents, describe modern methods of diagnosis and identification with clinical, mycological, imaging methods of examination and choose appropriate treatment and prevention in the practice of a family doctor in times of uncertainty.
Results. Numerous literary sources have testified that the main risk factor contributing to the development of mycosis pneumonia is a decrease in immunity. Constant stress and overstrain can be the cause of a decrease in protective forces during military operations. The issue of the role of clinical manifestations and paraclinical research methods in their diagnosis is highlighted. In the context of the problem, a wider implementation of combinations of mycological, serological and molecular examination methods is recommended for the diagnosis of mycosis pneumonia. Particular attention is paid to the question of prescribing antifungal drugs, taking into account diagnostic tests and individual characteristics of patients.
Conclusions. A comprehensive approach to the diagnosis and treatment of mycotic pneumonia is necessary to ensure the best outcomes for children and adolescents during times of uncertainty.
References
Nucci, M., Anaissie, E. (2020). Fungal Infections in Immunocompromised Hosts. Springer, 2020. 190–202. DOI: 10.1007/978-3-030-31861-9
Karadag, M., Goksen, C. (2019). EMDR therapy in children and adolescents who have post-traumatic stress disorder: a six-week follow-up study. International journal of Psychiatry in Clinical Practice. DOI: 10.1080/13651501. 2019.1682171 DOI: https://doi.org/10.1080/13651501.2019.1682171
Chong, P. K., & Thomas, B. (2017). Clinical features and treatment outcomes of Candida pneumonia in children. Infectious Diseases in Children, 15(3), 135-142. DOI: 10.1016/j.infectdis.2017.03.005
Ledoux, M.-P., Herbercht, R. (2023). Invasive pulmonary aspergillosis. Fungi, 9(2), 131-138. DOI: 10.3390/(jf9020131) DOI: https://doi.org/10.3390/jof9020131
Lass-Flörl, C. (2021). The Changing Face of Epidemiology of Invasive Fungal Infections: Therapeutic Implications. Clinical Microbiology and Infection, 322–330. DOI: 10.1016/j.cmi.2020.10.003 DOI: https://doi.org/10.1016/j.cmi.2020.10.003
Rajeshwari, R., Vyasam, S., Chandran, D. [et al.] (2022). Risk factors for candidiasis among children admitted to the pediatric intensive care unit of a tertiary care center in southern India. Indian J Crit Care Med, 26(6), 717-722. DOI: 10.5005/jp-journals-10071-24203 DOI: https://doi.org/10.5005/jp-journals-10071-24203
Lytvyn, O. L., (2022) Osoblyvosti nadannia medychnoi dopomohy v umovakh voiennoho stanu [Peculiarities of the provision of medical aid in the conditions of martial law]. Prykarpatskyi yurydychniu vistnyk – Carpathian legal herald. 1(42), 82-83. DOI: 10.32837/Pyuv.v.01(42)997 [in Ukrainian]
Chong, P.K., & Thomas, B. (2017). Clinical features and treatment outcomes of Candida pneumonia in children. Infectious Diseases in Children, 15(3), 135-142. DOI: 10.1016/j.infectdis.2017.03.005
Smith, J., Lee, A., Patel, R. (2023). Fungal Pneumonia in Children: Diagnostic and Treatment Updates. Journal of Pediatric Infectious Diseases. DOI: 10.1097/INF. 0000000000000000
Hage, A.C., Carmona, E.M., Epelbaum, O. [et al.] (2019). Microbiological Laboratory Testing in the Diagnosis of Fungal Infections in Pulmonary and Critical Care Practice. An Official American Thoracic Society Clinical Practice Guideline, 200(5), 535-550. DOI: 10.1164/rccm.201906-1185ST DOI: https://doi.org/10.1164/rccm.201906-1185ST
Wang, H., Zhang, W., Tang, Y-W. (2022). Clinical microbiology in detection and identification of emerging microbial pathogens: past, present and future. Emerg Microbes Infect., 11(1), 2579–2589. DOI: 10.1080/22221751. 2022.2125345 DOI: https://doi.org/10.1080/22221751.2022.2125345
Pham, D., Sivalingam, V., Tang H.M. (2024). Molecular Diagnostics for Invasive Fungal Diseases: Current and Future Approaches. J. Fungi, 10(7), 447. DOI: 10.3390/jof10070447 DOI: https://doi.org/10.3390/jof10070447
Maertens, J.A., Velegraki, A. (2020). Galactomannan and Other Fungal Antigen Testing. Clinical Microbiology Reviews, 33(4), 43–54. DOI:10.1128/CMR.00055-19
Bassetti, M., Bouza, E. (2021). Efficacy and Limitations of Antigen-Based Diagnostics in Fungal Infections. Journal of Antimicrobial Chemotherapy, 76(2), 327–334, DOI: 10.1093/jac/dkaa475. DOI: https://doi.org/10.1093/jac/dkaa475
López, A., & Rodríguez, J. (2021). The role of biomarkers in the diagnosis of fungal pneumonia. Medical Mycology, 59(2), 160-171. DOI: 10.1093/mmy/myab015 DOI: https://doi.org/10.1093/mmy/myab015
Sabino, R., Wiederhold, N. (2022). Diagnosis from Tissue: Histology and Identification. J. Fungi, 8(5), 505. DOI: 10.3390/jof8050505 DOI: https://doi.org/10.3390/jof8050505
Donnelly, J.P., Chen, S.C., Kauffman, C.A. [et al.] (2020). Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clinical Infectious Diseases, 71(6), 1367–1376. DOI: 10.1093/cid/ciz1008 DOI: https://doi.org/10.1093/cid/ciz1008
Hussain, F.A., Sohail, A. (2022). Doppler Ultrasonography in Pulmonary Fungal Infections. European Respiratory Journal, 60(2), 245–257. DOI: 10.1183/13993003.00489-2022
Buda, N., Tolu, R. (2021). Ultrasound Doppler Imaging in Pulmonary Infections. Journal of Clinical Imaging, 15(3), 315–330. DOI: 10.1016/j.jclinimg.2021.07.012
Müller, H., Schwarz, D. (2023). Fungal Pneumonia in Children: A Comprehensive Review of the Latest Treatment Guidelines. Mycoses. DOI: 10.1111/myc.13456 DOI: https://doi.org/10.1111/myc.13456
Smith, J., Lee, A., Patel, R. (2023). Fungal Pneumonia in Children: Diagnostic and Treatment Updates. Journal of Pediatric Infectious Diseases. DOI: 10.1097/INF. 0000000000000000
Johnson, M., Davis, T. (2023). Advances in the Treatment of Pediatric Invasive Fungal Infections. Clinical Infectious Diseases. DOI: 10.1093/cid/cia
Thompson, P., White, C. (2022). Trends in the Treatment of Pulmonary Fungal Infections in Children: An Evidence-Based Review. Pediatric Pulmonology. DOI: 10.1002/ppul.25689 DOI: https://doi.org/10.1002/ppul.25689
