COGNITIVE IMPAIRMENT IN CHILDREN WITH OBESITY AND LIPID AND CARBOHYDRATE METABOLISM DISORDERS IN COVID-19
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i4.15018Keywords:
children, obesity, insulin resistance, type 2 diabetes mellitus, non-alcoholic fatty liver disease, attention deficit hyperactivity disorder, cognitive impairment, diagnostics (lipid metabolism, carbohydrate metabolism), COVID-19, recurrent respiratory diseasesAbstract
SUMMARY. The study of cognitive behaviour in children with metabolic-associated diseases in COVID-19 is an urgent medical task.
The aim – to study the features of cognitive impairment in children with obesity and carbohydrate metabolism disorders in combination with non-alcoholic fatty liver disease (NAFLD) in COVID-19.
Material and Methods. The study included 76 children with attention-deficit hyperactivity disorder (ADHD) in the setting of NAFLD and obesity in COVID-19. The children were divided into two clinical groups depending on the form of carbohydrate metabolism disorder: group I (n=36) included children with type 2 diabetes mellitus (DM), and group II included 40 children with insulin resistance (IR). Cognitive impairment in children with NAFLD and obesity in COVID-19 was determined using the Conners-3 symptom questionnaire.
Results. There was a statistically significant increase in glucose, insulin, C-peptide, and HOMA-IR index in children of group II compared with those in group I. A significant increase in all lipid metabolism parameters in the blood serum of children with obesity and NAFLD in COVID-19 and ADHD was found, regardless of the form of carbohydrate metabolism disorder. In children of group I, the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were 1.2 (p<0.05), 1.6 (p<0.05), 1.3 (p<0.05) and 2.1 (p<0.01) times higher than in children of group II. Changes in cognitive functions in children with metabolically associated diseases closely correlate with the severity of liver function disorders, lipid and carbohydrate metabolism, which should be taken into account when diagnosing ADHD in children with metabolically disturbed background, especially in COVID-19.
Conclusions. In children with obesity and NAFLD after COVID-19, the severity of ADHD depends on impaired liver function, carbohydrate and lipid metabolism.
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