CHANGES IN NUTRITIONAL STATUS IN CHRONIC PANCREATITIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND OBESITY WITH ACETABULAR FRACTURES OF THE FEMUR
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i4.15016Keywords:
acetabular fracture of the femur, type 2 diabetes mellitus, chronic pancreatitis, pancreatic exocrine insufficiency, obesity, body mass index, nutritional statusAbstract
SUMMARY. Determining the features of trophological status in patients with type 2 diabetes mellitus (DM) and obesity, especially in combination with chronic pancreatitis (CP) in patients with acetabular fracture of the femur (AFF) is an urgent issue in patients with metabolic-associated diseases.
The aim – to investigate the features of nutritional status in patients with type 2 diabetes and obesity in the CP with AFF.
Materials and Methods. We examined 52 patients with type 2 diabetes mellitus and obesity in combination with CP and AFF. All patients underwent general clinical examinations and bioimpedance imaging.
Results. The results of respiratory tests, as well as changes in the concentration of faecal elastase-1 (FE-1), confirm the pancreatic exocrine insufficiency (PEI) in the examined patients. The level of FE-1 in patients was 73.7±4.3 μg E1/g faeces and indicated severe exocrine insufficiency of the pancreas. Assessment of trophological status in patients with type 2 diabetes mellitus and obesity and CP in bioimpedance study indicates a decrease in bone and muscle mass in the body. Moreover, the decrease in bone mass in patients with type 2 diabetes mellitus and obesity with CP directly depends on the severity of PEI according to breathing tests and the level of FE-1 (r=0.91; p<0.01 and r=0.88; p<0.01, respectively).
Conclusions. Determining the body composition in patients with type 2 diabetes mellitus and obesity in combination with CP in AFF, a deficiency of muscle and bone mass was found in combination with an increase in fat mass and fluid component, which directly depends on the pancreatic exocrine insufficiency.
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