ASSESSMENT OF GENDER AND AGE PARAMETERS OF PATIENTS WITH CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i3.14905Keywords:
chronic pancreatitis, biological age, sex, gender-age characteristicsAbstract
Summary. Knowledge of the gender-age characteristics of the course of chronic pancreatitis (CP) will make it possible to carry out rational treatment and prevention of the disease, which will prevent its irreversible consequences and complications.
The aim – to evaluate the results of the gender-age parameters of patients with chronic pancreatitis study.
Material and Methods. 341 patients with CP without exacerbation with accompanying pathology were examined. The age of the patients ranged from 21 to 78 years, which was (58.17±2.46) years on average. The examination was carried out on the basis of the Communal Non-Commercial Enterprise "Odesa Regional Clinical Medical Center" of the Odesa Regional Council and in the polyclinic department of the Ternopil Communal City Hospital No 2. The source of information was "Medical charts of an outpatient patient" (form 025/o) and "Medical charts of an inpatient patient" (form 027/o) of the patients with CP of various ages and sexes, examined during 2015-2023. The analysis of the obtained data was made using statistical methods.
Results. The analysis of groups by age showed that among young CP patients there were 31.6 % more men than women (65.8 % vs. 34.2 %). The average age of patients is (37.66±3.41) years. The difference between men and women in the average age category was 10.4% in favor of men. Average age – (59.32±4.33) years. Among older and elderly patients, women predominated over men by 20.6 % (60.3 % vs. 39.7% %). Average age – (71.34±1.45) years.
Conclusions. The established features of the gender-age characteristics of the study groups by age according to the WHO international classification require a differentiated approach to the management of patients with chronic pancreatitis, which requires further study of the clinical and pathogenetic features of age groups of patients with this disease.
References
Babinets, L.S., & Shevchenko N.O. (2017). Aktual'nist' vikovoho aspekta klinichnoho perebihu i vedennya khvorykh na khronichnyy pankreatyt [Actuality of the age-related aspect of clinical course and management of patients with chronic pancreatitis]. Zdobutky klinichnoyi ta eksperymental'noyi medytsyny – Achievements of Clinical and Experimental Medicine, 32(4), 5–11. https://doi.org/ 10.11603/1811-2471.2017.v0.i4.8318 [in Ukrainian].
Babinets, L.S., Shevchenko, N.O., Sasyk, H.M., & Zemlyak S.O. (2018). Dyslipidemiya ta chynnyky yiyi prohresuvannya pry komorbidnosti khronichnoho pankreatytu i tsukrvoho diabetu [Violation of lipid exchange and factors of its deepening at combination of chronic pancreatitis and diabetes mellitus]. Zdobutky klinichnoyi ta eksperymental'noyi medytsyny – Achievements of Clinical and Experimental Medicine, 1(33), 44–49. https://doi.org/10.11603/1811-2471.2018. v0.i1.8358 [in Ukrainian].
Babinets, L.S. (Ed.). (2024). Herontolohiya v simeyniy medytsyni [Gerontology in family medicine]. (Vols. 1–2). Lviv: Mahnoliya [in Ukrainian].
Pro zatverdzhennya Unifikovanoho klinichnoho protokolu pervynnoyi ta spetsializovanoyi medychnoyi dopomohy «Khronichnyy pankreatyt» [On the approval of the Unified Clinical Protocol of Primary and Specialized Medical Care "Chronic Pancreatitis"]. Nakaz MOZ Ukrayiny No 1204 (2023) (Ukryina). https://www.dec.gov.ua/mtd/hronichnyj-pankreatyt/ [in Ukrainian].
Mostovyi, Yu.M. (2022). Suchasni klasyfikatsiyi ta standarty likuvannya rozpovsyudzhenykh zakhvoryuvan' vnutrishnikh orhaniv [Modern classifications and standards of treatment of widespread diseases of internal organs]. (20th ed., add. and rework). Vinnytsya [in Ukrainian].
Mostovyi, Yu.M. (2019). Suchasni klasyfikatsiyi ta standarty likuvannya rozpovsyudzhenykh zakhvoryuvan' vnutrishnikh orhaniv [Modern classifications and standards of treatment of widespread diseases of internal organs]. (25th ed., add. and rework). Vinnytsya [in Ukrainian].
Khrystych, T.M., & Hontsaryuk D.O. (2018). Komorbidnist' khronichnoho pankreatytu z ishemichnoyu khvoroboyu sertsya: zahal'ni etiolohichni ta patohenetychni lanky rozvytku y osoblyvosti [Comorbidity of chronic pancreatitis with coronary heart disease: general etiological and pathogenetic links of development and peculiarities]. Zdorov᾽ya Ukrayiny – Health of Ukraine, 4, 34–37. http://health-ua.com/article/40060-komorbdnst-hronchnogo-pankreatitu-z-shemchnoyu-hvoroboyu-sertcya-zagaln-et [in Ukrainian].
Medychni kadry ta merezha zakladiv okhorony zdorov᾽ya systemy MOZ Ukrayiny za 2017–2018 roky [Medical personnel and the network of health care institutions of the Ministry of Health of Ukraine for 2017–2018]. (2019). Kyiv: Tsentr medychnoyi statystyky MOZ Ukrayiny. http://medstat.gov.ua/ukr/MMXVIII.html [in Ukrainian].
Shevchenko, N.O., & Babinets, L.S. (2006). Doslidzhennya vikovykh osoblyvostey perebihu khronichnoho pankreatytu ta sposoby yikh korektsiyi v ambulatorniy praktytsi [Study of age characteristics of the course of chronic pancreatitis and methods of their correction in outpatient practice]. Naukovi innovatsiyi – v praktyku simeynoyi medytsyny [Scientific innovations – in the practice of family medicine] (pp. 816–826). Lviv: Mahnoliya. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15096 [in Ukrainian].
Babinets, L.S., & Shevchenko, N.A. (2021). Analysis of antioxidant protection indicators from the position of age changes in chronic pancreatitis patients. Pharmacology Online, 2, 858–863. https://pharmacologyonline.silae.it/files/archives/2021/vol2/PhOL_2021_2_A100_Babinets.pdf
Shevchenko, N.O., & Babinets, L.S. (2021). The effectiveness of systemic enzyme therapy in complex treatment chronic pancreatitis in old age. Journal of Education, Health and Sport, 11(06), 209–216. http://dx.doi.org/ 10. 12775/JEHS.2021.11.06.023
Babinets, L.S., Shevchenko, N.A., Sasyk, H.N., & Zemlyak, О.S. (2017). Research of lipid exchange diffusion of medium-age patients with chronic pancreatitis with diabetes mellitus. Journal of Education, Health and Sport, 7(11), 309–318. https://repo.odmu.edu.ua/xmlui/handle/123456789/9419
Beyer, G., Habtezion, A., Werner, J., Lerch, M.M., & Mayerle, J. (2020). Chronic pancreatitis. Lancet (London, England), 396(10249), 499–512. https://doi.org/10.1016/S0140-6736(20)31318-0
Coté, G.A., Yadav, D., Slivka, A., Hawes, R.H., Anderson, M.A., Burton, F. R., et al. (2011). Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 9(3), 266–e27. https://doi.org/10.1016/j.cgh.2010.10.015
DeSouza, S.V., Singh, R.G., Yoon, H.D., Murphy, R., Plank, L.D., & Petrov, M.S. (2018). Pancreas volume in health and disease: a systematic review and meta-analysis. Expert review of gastroenterology & hepatology, 12(8), 757–766. https://doi.org/10.1080/17474124.2018.1496015
Dominguez-Munoz, J.E., Drewes, A.M., Lindkvist, B., Ewald, N., Czakó, L., Rosendahl, J., et al. (2018). Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 18(8), 847–854. https://doi.org/10.1016/j.pan.2018.09.016
Gardner, T.B., Adler, D.G., Forsmark, C.E., Sauer, B.G., Taylor, J.R., & Whitcomb, D.C. (2020). ACG Clinical Guideline: Chronic Pancreatitis. The American journal of gastroenterology, 115(3), 322–339. https://doi.org/10.14309/ajg. 0000000000000535
Samokhvalov, A.V., Rehm, J., & Roerecke, M. (2015). Alcohol Consumption as a Risk Factor for Acute and Chronic Pancreatitis: A Systematic Review and a Series of Meta-analyses. EBioMedicine, 2(12), 1996–2002. https://doi.org/10. 1016/j.ebiom.2015.11.023
Shevchenko, N., Babinets, L., & Halabitska, I. (2022). Age-dependent immune status chenges in chronic pancreatitis patients. Georgian Medical News, 330(9), 54–58. https://repo.odmu.edu.ua:443/xmlui/handle/123456789/15070
Schneider, A., Löhr, J.M., & Singer, M.V. (2007). The M-ANNHEIM classification of chronic pancreatitis: introduction of a unifying classification system based on a review of previous classifications of the disease. Journal of gastroenterology, 42(2), 101–119. https://doi.org/10.1007/s00535-006-1945-4
Syed, A., Babich, O., Thakkar, P., Patel, A., Abdul-Baki, H., Farah, K., et al. (2019). Defining Pancreatitis as a Risk Factor for Pancreatic Cancer: The Role, Incidence, and Timeline of Development. Pancreas, 48(8), 1098–1101. https://doi.org/10.1097/MPA.0000000000001367
Tana, C., Silingardi, M., Giamberardino, M.A., Cipollone, F., Meschi, T., & Schiavone, C. (2017). Emphysematous pancreatitis associated with penetrating duodenal ulcer. World journal of gastroenterology, 23(48), 8666–8670. https://doi.org/10.3748/wjg.v23.i48.8666
Viun, T., Pasieshvili, L. (2018). Pathogenetic links of the combined course of chronic pancreatitis and hypertensive disease and their role in the formation of complications. Georgian Med News, 283, 81–84.
Watanabe, T., Kudo, M., & Strober, W. (2017). Immunopathogenesis of pancreatitis. Mucosal immunology, 10(2), 283–298. https://doi.org/10.1038/mi.2016.101
