THE IMPACT OF CORONAVIRUS DISEASE COVID-19 ON THE COURSE OF MENTAL DISORDERS IN PATIENTS WITH A HISTORY OF MENTAL DISTURBANCES
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i3.14902Keywords:
mental disorders, coronavirus disease COVID-19, course dynamics, structure of clinical and psychopathological manifestationsAbstract
SUMMARY. Mental disorders after COVID-19 are caused by various factors and have a polymorphic nature, but the available data on the course of these disorders are contradictory.
The aim – to investigate the clinical and psychopathological consequences of COVID-19 in patients with a history of mental disorders, whose condition worsened after the coronavirus disease, and their impact on the course of these disorders.
Material and Methods. 95 patients with a history of mental disorders who have experienced COVID-19 and were exposed to the stressors of the SARS-CoV-2 pandemic were examined and made up the main group. The comparison group included 58 people without mental disorders who have experienced and were exposed to the stressors of the SARS-CoV-2 pandemic. A comprehensive approach was applied, which included clinical-psychopathological, clinical-anamnestic (using the developed questionnaire containing questions that reflect the impact of the coronavirus disease COVID-19 and the stressors of the SARS-CoV-2 pandemic on the mental health), psychometric (using the Clinical Global Impression Scale (CGI)) and statistical methods.
Results. The results of the study made it possible to establish that the psychopathological consequences of the complex impact of the COVID-19 coronavirus disease and the stressors of the SARS-CoV-2 pandemic become the basis for the deterioration of the mental state of persons with a history of mental disorders. A comparison of the dynamics of the course of current mental disorders after COVID-19 and previous mental disorders in the anamnesis of the studied patients was carried out according to indicators of the duration and severity of mental disorders, as well as the duration of the remission that preceded them. The obtained data confirm the complex impact of the SARS-CoV-2 pandemic on the formation and aggravation of mental disorders, indicate a tendency to increase the severity of mental disorders as a result of the coronavirus disease, and give reason to put forward a hypothesis about an increase in the duration of mental disorders after COVID-19. The structure of the leading clinical-psychopathological manifestations of mental disorders after COVID-19, which was characterized by the predominance of affective symptoms of the anxiety-depressive spectrum in combination with pronounced specific cognitive, ideational and somato-vegetative disturbances, as well as disturbances of the effector-volitional sphere, was studied.
References
Badinlou, F., Rahimian, F., Hedman Lagerlöf, M., Lundgren, T., Abzhandadze, T., & Jansson Fröjmark, M. (2024). Trajectories of mental health outcomes following COVID-19 infection: a prospective longitudinal study. BMC Public Health, 24, 452. DOI: 10.1186/s12889-024-17997-x
Scott, E. S., Lubetkin, E. I., Janssen, M. F., Fantopolous, J., Bonsel, G. J., & Haagsma, J. A. (2023). Cross-sectional and longitudinal comparison of health-related quality of life and mental well-being between persons with and without post COVID-19 condition. Frontiers in Epidemiology, 3, 1144162. DOI: 10.3389/fepid.2023.1144162
Cénat, J. M., Farahi, S. M. M. M., Dalexis, R. D., Darius, W. P., Bekarkhanechi, F. M., Poisson, H., Broussard, C., et al. (2022). The global evolution of mental health problems during the COVID-19 pandemic: A systematic review and meta-analysis of longitudinal studies. Journal of Affective Disorders, 315, 70-95. DOI: 10.1016/j.jad.2022.07.011
Schieber, L. Z., Dunphy, C., Schieber, R. A., Lopes-Cardozo, B., Moonesinghe, R., & Guy, G. P. Jr. (2023). Hospitalization associated with comorbid psychiatric and substance use disorders among adults with COVID-19 Treated in US emergency departments from April 2020 to August 2021. JAMA Psychiatry, 80(4), 331-341. DOI: 10.1001/jamapsychiatry.2022.5047
Poletti, S., Palladini, M., Mazza, M.G., De Lorenzo, R. (2022). Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of life. European Archives of Psychiatry and Clinical Neuroscience, 272(5), 773-782. DOI: 10.1007/s00406-021-01346-9
Leung, C. M. C., Ho, M. K., Bharwani, A. A., Cogo-Moreira, H., Wang, Y., Chow, M. S. C., et al. (2022). Mental disorders following COVID-19 and other epidemics: a systematic review and meta-analysis. Translational Psychiatry, 12(1), 205. DOI: 10.1038/s41398-022-01946-6
Rogers, J. P., Chesney, E., Oliver, D., Pollak, T. A., McGuire, P., Fusar-Poli, P., Zandi, M. S., Lewis, G., & David, A. S. (2020). Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. Lancet Psychiatry, 7(7), 611-27. DOI: 10.1016/S2215-0366(20)30203-0 18
Nakao, T., Murayama, K., Fukuda, H., Eto, N., Fujita, K., Igata, R., et al. (2023). Survey of psychiatric symptoms among inpatients with COVID-19 using the Diagnosis Procedure Combination data and medical records in Japan. Brain, Behavior, and Immunity – Health, 29, 100615. DOI: 10.1016/j.bbih.2023.100615
Mazza, M. G., Palladini, M., Poletti, S., & Benedetti, F. (2022). Post-COVID-19 depressive symptoms: epidemiology, pathophysiology, and pharmacological treatment. CNS Drugs, 36(7), 681-702. DOI: 10.1007/s40263-022-00931-3
Meaklim, H., Saunders, W. J., Byrne, M. L., Junge, M. F., Varma, P., Finck, W. A., & Jackson, M. L. (2023). Insomnia is a key risk factor for persistent anxiety and depressive symptoms: A 12-month longitudinal cohort study during the COVID-19 pandemic. Journal of Affective Disorders, 322, 52-62. DOI: 10.1016/j.jad.2022.11.021.
Ausserhofer, D., Mahlknecht, A., Engl, A., Piccoliori, G., Pfitscher, G., Silbernagl, P., et al. (2023). Relationship between depression, anxiety, stress, and SARS-CoV-2 infection: a longitudinal study. Frontiers in Psychology, 14, 1116566. DOI: 10.3389/fpsyg.2023.1116566
Taquet, M., Luciano, S., Geddes, J. R., & Harrison, P. J. (2021). Bidirectional Associations between COVID-19 and Psychiatric Disorder: Retrospective Cohort Studies of 62 354 COVID-19 Cases in the USA. Lancet Psychiatry, 8, 130-140. DOI: 10.1016/S2215-0366(20)30462-4
Tokuda, Y., Barnett, P. B., Sanji, S., Takaizumi, Y., Tomono, M., Tokuda, H., Taniguchi, K., & Shibuya, K. (2023). Serious mental illness and in-hospital mortality among hospitalized patients with acute COVID-19: A large database analysis in Japan. General Hospital Psychiatry, 82, 1-6. DOI: 10.1016%2Fj.genhosppsych.2023.01.014
Hofer, A., Kachel, T., Plattner, B., Chernova, A., Conca, A., Fronthaler, M., et al. (2022). Mental health in individuals with severe mental disorders during the COVID-19 pandemic: a longitudinal investigation. NPJ Schizophrenia, 8(1), 17. DOI: 10.1038/s41537-022-00225-z
Molero, P., Reina, G., Blom, J. D., Martínez-González, M. Á., Reinken, A., de Kloet, E.R., Molendijk, M. L. (2023). COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses. Epidemiology and Psychiatric Sciences, 32, 61. DOI: 10.1017/S2045796023000719
Hüfner, K., Tymoszuk, P., Ausserhofer, D., Sahanic, S., Pizzini, A., Rass, V., et al. (2022). Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management? Frontiers in Medicine, 9, 792881. DOI: 10.3389/fmed.2022.792881
Bertolini, F., Witteveen, A.B., Young, S., Cuijpers, P., Ayuso-Mateos, J.L., Barbui, C., et al. (2023). Risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 mortality in people with pre-existing mental disorders: an umbrella review. BMC Psychiatry, 23(1), 181. DOI: 10.1186/s12888-023-04641-y
Lee, S.W., Yang, J.M., Moon, S.Y., Kim, N., Ahn, Y.M., Kim, J.M., et al. (2021). Association between mental illness and COVID-19 in South Korea: a post-hoc analysis. Lancet Psychiatry, 8(4), 271-72. DOI: 10.1016/S2215-0366(21)00043-2
Cheng, W.-J., Shih, H.-M., Su, K.-P., & Hsueh, P.-R. (2023). Risk factors for poor COVID-19 outcomes in patients with psychiatric disorders. Brain, Behavior, and Immunity – Health, 114, 255-61. DOI: 10.1016/j.bbi.2023.08.024
Hazumi, M., Usuda, K., Okazaki, E., Kataoka, M., & Nishi, D. (2022). Differences in the Course of Depression and Anxiety after COVID-19 Infection between Recovered Patients with and without a Psychiatric History: A Cross-Sectional Study. International Journal of Environmental Research and Public Health, 19(18), 11316. DOI: 10.3390/ijerph191811316
Maruta, N. O., Fedchenko, V. Y., Yavdak, I. O., Panko, T. V., & Semikina O. E. (2023). [Copyright of the work: Questionnaire for patients with mental disorders who have experienced the coronavirus disease COVID-19 and were exposed to the stressors of the SARS-COV-2 pandemic]. Application from 13.03.2023 с202301564; certificate from 11.04.2023 № 118009. [in Ukrainian].
Busner, J. (2007). The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry (Edgmont), 4(7), 28-37.
Order of the Ministry of Health of Ukraine from 27.10.2020 № 2438 [«On making changes to the Medical Care Standards "Coronavirus Disease (COVID-19)"»]. Ukrainian. [Internet]. [cited 2024 Jul 26]. Available from: https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-27102020--2438-pro-vnesennja-zmin-do-standartiv-medichnoi-dopomogi-koronavirusna-hvoroba-covid-19
Yang, R., Li, X., Liu, H., et al. (2020). Chest CT Severity Score: an imaging tool for assessing severe COVID-19. Radiology: Cardiothorac Imaging, 2(2), 200047. DOI: 10.1148/ ryct.2020200047
Walters, S. J., Campbell, M. J., & Machin, D. (2021). Medical Statistics: A Textbook for the Health Sciences. 5th ed. Wiley-Blackwell, 448 p.
