CLINICAL VARIANTS OF THE COURSE OF HYPER INFLAMMATION SYNDROME IN PATIENTS WITH COVID-19
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i2.14727Keywords:
COVID-19, cytokine storm syndromeAbstract
SUMMARY. The aim – to study the features of the clinical course of COVID-19.
Material and Methods. 270 patients with a severe course of COVID-19, bilateral polysegmental pneumonia took part in a retrospective study. In addition to general clinical tests, the content of ferritin, interleukin-6, D-dimer, fibrinogen, procalcitonin, C-reactive protein were determined in all patients. According to the relevant diagnostic criteria, three groups of patients with different subtypes of cytokine storm syndrome were identified: macrophage activation syndrome, cytokine release syndrome, and sepsis. We tried to evaluate which of the above-mentioned subtypes occurred more often, what are the clinical manifestations of these subtypes.
Results. Macrophage activation syndrome was diagnosed in 8.9 % of those examined, cytokine release syndrome in 81.8 %, and sepsis in 9.3 %. Serum ferritin content in patients with macrophage activation syndrome was significantly higher (p<0.05) compared to those with cytokine release syndrome and compared to the patients with sepsis. Hypofibrinogenemia and pancytopenia were also observed in patients with macrophage release syndrome.
Conclusions. Among the cytokine storm syndromes in patients with COVID-19, the cytokine release syndrome is the most common (81.8 %).
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