LABORATORY SIGNS OF DIFFERENTIATION OF METABOLIC-ASSOCIATED STEATOSIS OF THE LIVER FROM ITS INTACT STATE
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i2.14722Keywords:
Metabolic dysfunction-associated steatotic liver, alanine aminotransferase, De Ritis ratio, hepatic steatosis index, triglyceride-glucose indexAbstract
SUMMARY. The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is constantly increasing, but the diagnosis of its initial stage – metabolic dysfunction-associated steatotic liver (MASL) is often difficult, especially in the early stage of MASL.
The aim – to substantiate the calculated complex laboratory indicator for differentiating MASL from the intact state.
Materials and Methods. The study included 641 patients who were divided into a main group with concomitant MASL and a control group with an intact liver. The results of their examination were evaluated. Additionally, the De Ritis ratio, hepatic steatosis index, triglyceride-glucose index, ratio of neutrophils to lymphocytes and AST to platelets, BARD scale, four-component fibrosis index were determined for the patients. The results were analyzed statistically with determination of the odds ratio.
Results. The probability of MASL increases four times with an increase in the hepatic steatosis index >36 points (p=0.0001), three times with a moderate increase in ALT (p=0.0004) and two times with a decrease in the De Ritis ratio<1.0 (p=0.0012) or an increase in the triglyceride-glucose index >4.0 (p=0.0262). Changes in AST, ratio of neutrophils to lymphocytes and AST to platelets, BARD scale and four-component fibrosis index were not significant for differentiation.
Conclusions. It is proposed to determine the total indicator of differentiation of MASL from an intact liver, which makes it possible to diagnose a definite, highly probable or doubtful diagnosis of MASL.
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